@article{lepowsky_paper-based_2017,
	title = {Paper-based assays for urine analysis},
	volume = {11},
	issn = {1932-1058},
	url = {http://dx.doi.org/10.1063/1.4996768},
	doi = {10.1063/1.4996768},
	abstract = {A transformation of the healthcare industry is necessary and imminent:
hospital-centered, reactive care will soon give way to proactive,
person-centered care which focuses on individuals' well-being. However,
this transition will only be made possible through scientific innovation.
Next-generation technologies will be the key to developing affordable and
accessible care, while also lowering the costs of healthcare. A promising
solution to this challenge is low-cost continuous health monitoring; this
approach allows for effective screening, analysis, and diagnosis and
facilitates proactive medical intervention. Urine has great promise for
being a key resource for health monitoring; unlike blood, it can be
collected effortlessly on a daily basis without pain or the need for
special equipment. Unfortunately, the commercial rapid urine analysis
tests that exist today can only go so far-this is where the promise of
microfluidic devices lies. Microfluidic devices have a proven record of
being effective analytical devices, capable of controlling the flow of
fluid samples, containing reaction and detection zones, and displaying
results, all within a compact footprint. Moving past traditional glass-
and polymer-based microfluidics, paper-based microfluidic devices possess
the same diagnostic ability, with the added benefits of facile
manufacturing, low-cost implementation, and disposability. Hence, we
review the recent progress in the application of paper-based microfluidics
to urine analysis as a solution to providing continuous health monitoring
for proactive care. First, we present important considerations for
point-of-care diagnostic devices. We then discuss what urine is and how
paper functions as the substrate for urine analysis. Next, we cover the
current commercial rapid tests that exist and thereby demonstrate where
paper-based microfluidic urine analysis devices may fit into the
commercial market in the future. Afterward, we discuss various fabrication
techniques that have been recently developed for paper-based microfluidic
devices. Transitioning from fabrication to implementation, we present some
of the clinically implemented urine assays and their importance in
healthcare and clinical diagnosis, with a focus on paper-based
microfluidic assays. We then conclude by providing an overview of select
biomarker research tailored towards urine diagnostics. This review will
demonstrate the applicability of paper-based assays for urine analysis and
where they may fit into the commercial healthcare market.},
	number = {5},
	journal = {Biomicrofluidics},
	author = {Lepowsky, Eric and Ghaderinezhad, Fariba and Knowlton, Stephanie and Tasoglu, Savas},
	month = sep,
	year = {2017},
	keywords = {Savas Scholar},
	pages = {051501},
}

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A promising solution to this challenge is low-cost continuous health monitoring; this approach allows for effective screening, analysis, and diagnosis and facilitates proactive medical intervention. Urine has great promise for being a key resource for health monitoring; unlike blood, it can be collected effortlessly on a daily basis without pain or the need for special equipment. Unfortunately, the commercial rapid urine analysis tests that exist today can only go so far-this is where the promise of microfluidic devices lies. Microfluidic devices have a proven record of being effective analytical devices, capable of controlling the flow of fluid samples, containing reaction and detection zones, and displaying results, all within a compact footprint. Moving past traditional glass- and polymer-based microfluidics, paper-based microfluidic devices possess the same diagnostic ability, with the added benefits of facile manufacturing, low-cost implementation, and disposability. Hence, we review the recent progress in the application of paper-based microfluidics to urine analysis as a solution to providing continuous health monitoring for proactive care. First, we present important considerations for point-of-care diagnostic devices. We then discuss what urine is and how paper functions as the substrate for urine analysis. Next, we cover the current commercial rapid tests that exist and thereby demonstrate where paper-based microfluidic urine analysis devices may fit into the commercial market in the future. Afterward, we discuss various fabrication techniques that have been recently developed for paper-based microfluidic devices. Transitioning from fabrication to implementation, we present some of the clinically implemented urine assays and their importance in healthcare and clinical diagnosis, with a focus on paper-based microfluidic assays. We then conclude by providing an overview of select biomarker research tailored towards urine diagnostics. This review will demonstrate the applicability of paper-based assays for urine analysis and where they may fit into the commercial healthcare market.","number":"5","journal":"Biomicrofluidics","author":[{"propositions":[],"lastnames":["Lepowsky"],"firstnames":["Eric"],"suffixes":[]},{"propositions":[],"lastnames":["Ghaderinezhad"],"firstnames":["Fariba"],"suffixes":[]},{"propositions":[],"lastnames":["Knowlton"],"firstnames":["Stephanie"],"suffixes":[]},{"propositions":[],"lastnames":["Tasoglu"],"firstnames":["Savas"],"suffixes":[]}],"month":"September","year":"2017","keywords":"Savas Scholar","pages":"051501","bibtex":"@article{lepowsky_paper-based_2017,\n\ttitle = {Paper-based assays for urine analysis},\n\tvolume = {11},\n\tissn = {1932-1058},\n\turl = {http://dx.doi.org/10.1063/1.4996768},\n\tdoi = {10.1063/1.4996768},\n\tabstract = {A transformation of the healthcare industry is necessary and imminent:\nhospital-centered, reactive care will soon give way to proactive,\nperson-centered care which focuses on individuals' well-being. However,\nthis transition will only be made possible through scientific innovation.\nNext-generation technologies will be the key to developing affordable and\naccessible care, while also lowering the costs of healthcare. A promising\nsolution to this challenge is low-cost continuous health monitoring; this\napproach allows for effective screening, analysis, and diagnosis and\nfacilitates proactive medical intervention. Urine has great promise for\nbeing a key resource for health monitoring; unlike blood, it can be\ncollected effortlessly on a daily basis without pain or the need for\nspecial equipment. Unfortunately, the commercial rapid urine analysis\ntests that exist today can only go so far-this is where the promise of\nmicrofluidic devices lies. Microfluidic devices have a proven record of\nbeing effective analytical devices, capable of controlling the flow of\nfluid samples, containing reaction and detection zones, and displaying\nresults, all within a compact footprint. Moving past traditional glass-\nand polymer-based microfluidics, paper-based microfluidic devices possess\nthe same diagnostic ability, with the added benefits of facile\nmanufacturing, low-cost implementation, and disposability. Hence, we\nreview the recent progress in the application of paper-based microfluidics\nto urine analysis as a solution to providing continuous health monitoring\nfor proactive care. First, we present important considerations for\npoint-of-care diagnostic devices. We then discuss what urine is and how\npaper functions as the substrate for urine analysis. Next, we cover the\ncurrent commercial rapid tests that exist and thereby demonstrate where\npaper-based microfluidic urine analysis devices may fit into the\ncommercial market in the future. Afterward, we discuss various fabrication\ntechniques that have been recently developed for paper-based microfluidic\ndevices. Transitioning from fabrication to implementation, we present some\nof the clinically implemented urine assays and their importance in\nhealthcare and clinical diagnosis, with a focus on paper-based\nmicrofluidic assays. We then conclude by providing an overview of select\nbiomarker research tailored towards urine diagnostics. This review will\ndemonstrate the applicability of paper-based assays for urine analysis and\nwhere they may fit into the commercial healthcare market.},\n\tnumber = {5},\n\tjournal = {Biomicrofluidics},\n\tauthor = {Lepowsky, Eric and Ghaderinezhad, Fariba and Knowlton, Stephanie and Tasoglu, Savas},\n\tmonth = sep,\n\tyear = {2017},\n\tkeywords = {Savas Scholar},\n\tpages = {051501},\n}\n\n","author_short":["Lepowsky, E.","Ghaderinezhad, F.","Knowlton, S.","Tasoglu, S."],"key":"lepowsky_paper-based_2017","id":"lepowsky_paper-based_2017","bibbaseid":"lepowsky-ghaderinezhad-knowlton-tasoglu-paperbasedassaysforurineanalysis-2017","role":"author","urls":{"Paper":"http://dx.doi.org/10.1063/1.4996768"},"keyword":["Savas Scholar"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/f/tdeNjdGRvEjCj6poY/Paperpile - Savas Scholar - Sep 29_9_55.bib","dataSources":["o4FjzKmMLbNsJeCiA","ug28hqM3LvcrR5ooy","rpTabu3QjqyjXfwJx","WNeEW7TRQofgFJWZF","e4sXQAiZBnJpitypW","ju36gB4zmmNQMHn4H","z3Bax9WQP5R35XnHo"],"keywords":["savas scholar"],"search_terms":["paper","based","assays","urine","analysis","lepowsky","ghaderinezhad","knowlton","tasoglu"],"title":"Paper-based assays for urine analysis","year":2017}