Long-term outcome of oesophageal atresia in adolescence (TransEAsome): a national French cohort study protocol. Leroy, M., Aumar, M., Duhamel, M., Dauchet, L., Figeac, M., Gaillard, S., Hankard, R., Labreuche, J., Marot, G., Reversat, J., Armand, V., Salzet, M., Sfeir, R., Vandel, J., & Gottrand, F. BMJ open, 15(1):e086303, January, 2025. ![Long-term outcome of oesophageal atresia in adolescence (TransEAsome): a national French cohort study protocol [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex 2 downloads INTRODUCTION: The TransEAsome project, funded by the Agence Nationale de la Recherche, aims to evaluate the long-term outcomes of patients with oesophageal atresia (OA) between 13 and 14 years old and establish multiomics profiles using data from the world's biggest OA registry. METHODS AND ANALYSIS: TransEAsome is a national multicentre population-based cohort study recruiting participants from all qualified French centres for OA surgery at birth. The primary objective is to assess the prevalence of gastro-oesophageal reflux disease in adolescence among patients with OA, with several secondary objectives including the identification of risk factors and multiomic profiles from oesophageal biopsies and blood samples collected between 13 and 14 years old, compared with a control group. This comprehensive characterisation of phenotype and omic profiles aims to enhance the understanding of disease evolution in patients with OA and inform tailored care management strategies. ETHICS AND DISSEMINATION: The study, coconstructed with input from patients, parents and research-expert adolescents, has obtained approval from the ethics research committee: Comité de protection des personnes Est II. Findings will be disseminated to various target audiences, including the scientific community, research participants, the patient community, the general public, regulatory authorities and policymakers. Data will be made available in a Findable, Accessible, Interoperable, Reusable format on the France Cohortes platform on study completion. TRIAL REGISTRATION NUMBER: NCT05995171:Clinical trial.
@article{leroy_long-term_2025,
title = {Long-term outcome of oesophageal atresia in adolescence ({TransEAsome}): a national {French} cohort study protocol},
volume = {15},
issn = {2044-6055},
shorttitle = {Long-term outcome of oesophageal atresia in adolescence ({TransEAsome})},
url = {http://hdl.handle.net/20.500.12210/119304},
doi = {10.1136/bmjopen-2024-086303},
abstract = {INTRODUCTION: The TransEAsome project, funded by the Agence Nationale de la Recherche, aims to evaluate the long-term outcomes of patients with oesophageal atresia (OA) between 13 and 14 years old and establish multiomics profiles using data from the world's biggest OA registry.
METHODS AND ANALYSIS: TransEAsome is a national multicentre population-based cohort study recruiting participants from all qualified French centres for OA surgery at birth. The primary objective is to assess the prevalence of gastro-oesophageal reflux disease in adolescence among patients with OA, with several secondary objectives including the identification of risk factors and multiomic profiles from oesophageal biopsies and blood samples collected between 13 and 14 years old, compared with a control group. This comprehensive characterisation of phenotype and omic profiles aims to enhance the understanding of disease evolution in patients with OA and inform tailored care management strategies.
ETHICS AND DISSEMINATION: The study, coconstructed with input from patients, parents and research-expert adolescents, has obtained approval from the ethics research committee: Comité de protection des personnes Est II. Findings will be disseminated to various target audiences, including the scientific community, research participants, the patient community, the general public, regulatory authorities and policymakers. Data will be made available in a Findable, Accessible, Interoperable, Reusable format on the France Cohortes platform on study completion.
TRIAL REGISTRATION NUMBER: NCT05995171:Clinical trial.},
language = {eng},
number = {1},
journal = {BMJ open},
author = {Leroy, Mélanie and Aumar, Madeleine and Duhamel, Marie and Dauchet, Luc and Figeac, Martin and Gaillard, Segolene and Hankard, Regis and Labreuche, Julien and Marot, Guillemette and Reversat, Julie and Armand, Viviane and Salzet, Michel and Sfeir, Rony and Vandel, Jimmy and Gottrand, Frédéric},
month = jan,
year = {2025},
keywords = {Adolescent, Adolescents, Cohort Studies, Esophageal Atresia, Female, France, Gastroesophageal Reflux, Humans, Male, Oesophageal disease, Paediatric gastroenterology, Patient Reported Outcome Measures, Prevalence, Quality of Life, Registries, Research Design, Risk Factors},
pages = {e086303},
}
Downloads: 2
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METHODS AND ANALYSIS: TransEAsome is a national multicentre population-based cohort study recruiting participants from all qualified French centres for OA surgery at birth. The primary objective is to assess the prevalence of gastro-oesophageal reflux disease in adolescence among patients with OA, with several secondary objectives including the identification of risk factors and multiomic profiles from oesophageal biopsies and blood samples collected between 13 and 14 years old, compared with a control group. This comprehensive characterisation of phenotype and omic profiles aims to enhance the understanding of disease evolution in patients with OA and inform tailored care management strategies. ETHICS AND DISSEMINATION: The study, coconstructed with input from patients, parents and research-expert adolescents, has obtained approval from the ethics research committee: Comité de protection des personnes Est II. 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