Neural signatures of sleep in zebrafish. Leung, L. C., Wang, G. X., Madelaine, R., Skariah, G., Kawakami, K., Deisseroth, K., Urban, A. E., & Mourrain, P. Nature, 571(7764):198–204, July, 2019. Publisher: Nature Publishing Group![Neural signatures of sleep in zebrafish [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Slow-wave sleep and rapid eye movement (or paradoxical) sleep have been found in mammals, birds and lizards, but it is unclear whether these neuronal signatures are found in non-amniotic vertebrates. Here we develop non-invasive fluorescence-based polysomnography for zebrafish, and show—using unbiased, brain-wide activity recording coupled with assessment of eye movement, muscle dynamics and heart rate—that there are at least two major sleep signatures in zebrafish. These signatures, which we term slow bursting sleep and propagating wave sleep, share commonalities with those of slow-wave sleep and paradoxical or rapid eye movement sleep, respectively. Further, we find that melanin-concentrating hormone signalling (which is involved in mammalian sleep) also regulates propagating wave sleep signatures and the overall amount of sleep in zebrafish, probably via activation of ependymal cells. These observations suggest that common neural signatures of sleep may have emerged in the vertebrate brain over 450 million years ago.
@article{leung_neural_2019,
title = {Neural signatures of sleep in zebrafish},
volume = {571},
copyright = {2019 The Author(s), under exclusive licence to Springer Nature Limited},
issn = {1476-4687},
url = {https://www.nature.com/articles/s41586-019-1336-7},
doi = {10.1038/s41586-019-1336-7},
abstract = {Slow-wave sleep and rapid eye movement (or paradoxical) sleep have been found in mammals, birds and lizards, but it is unclear whether these neuronal signatures are found in non-amniotic vertebrates. Here we develop non-invasive fluorescence-based polysomnography for zebrafish, and show—using unbiased, brain-wide activity recording coupled with assessment of eye movement, muscle dynamics and heart rate—that there are at least two major sleep signatures in zebrafish. These signatures, which we term slow bursting sleep and propagating wave sleep, share commonalities with those of slow-wave sleep and paradoxical or rapid eye movement sleep, respectively. Further, we find that melanin-concentrating hormone signalling (which is involved in mammalian sleep) also regulates propagating wave sleep signatures and the overall amount of sleep in zebrafish, probably via activation of ependymal cells. These observations suggest that common neural signatures of sleep may have emerged in the vertebrate brain over 450 million years ago.},
language = {en},
number = {7764},
urldate = {2025-07-09},
journal = {Nature},
author = {Leung, Louis C. and Wang, Gordon X. and Madelaine, Romain and Skariah, Gemini and Kawakami, Koichi and Deisseroth, Karl and Urban, Alexander E. and Mourrain, Philippe},
month = jul,
year = {2019},
note = {Publisher: Nature Publishing Group},
keywords = {Fluorescence imaging, Neurophysiology, REM sleep, Sleep, Slow-wave sleep, sleep, zebrafish},
pages = {198--204},
}
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