@article{
 title = {Switchable self-protected attractions in DNA-functionalized colloids},
 type = {article},
 year = {2009},
 identifiers = {[object Object]},
 pages = {590-595},
 volume = {8},
 month = {7},
 publisher = {NATURE PUBLISHING GROUP},
 city = {MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND},
 id = {11588d5b-898f-3e14-9dbe-ed1672a3cdf5},
 created = {2015-12-14T19:51:31.000Z},
 file_attached = {false},
 profile_id = {3187ec9d-0fcc-3ba2-91e0-3075df9b18c3},
 group_id = {d75e47fd-ff52-3a4b-bf1e-6ebc7e454352},
 last_modified = {2017-03-14T12:30:08.401Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {ISI:000267204600020},
 source_type = {article},
 user_context = {Article},
 private_publication = {false},
 abstract = {Surface functionalization with DNA is a powerful tool for guiding the
self-assembly of nanometre- and micrometre-sized particles(1-11).
Complementary `sticky ends' form specific inter-particle links and
reproducibly bind at low temperature and unbind at high temperature.
Surprisingly, the ability of single-stranded DNA to form folded
secondary structures has not been explored for controlling (nano)
colloidal assembly processes, despite its frequent use in DNA
nanotechnology(12-14). Here, we show how loop and hairpin formation in
the DNA coatings of micrometre-sized particles gives us in situ control
over the inter-particle binding strength and association kinetics. We
can finely tune and even switch off the attractions between particles,
rendering them inert unless they are heated or held together-like a
nano-contact glue. The novel kinetic control offered by the switchable
self-protected attractions is explained with a simple quantitative model
that emphasizes the competition between intra- and inter-particle
hybridization, and the practical utility is demonstrated by the assembly
of designer clusters in concentrated suspensions. With self-protection,
both the suspension and assembly product are stable, whereas
conventional attractive colloids would quickly aggregate. This
remarkable functionality makes our self-protected colloids a novel
material that greatly extends the utility of DNA-functionalized systems,
enabling more versatile, multi-stage assembly approaches.},
 bibtype = {article},
 author = {Leunissen, Mirjam E and Dreyfus, Remi and Cheong, Fook Chiong and Grier, David G and Sha, Roujie and Seeman, Nadrian C and Chaikin, Paul M},
 journal = {NATURE MATERIALS},
 number = {7}
}

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Here, we show how loop and hairpin formation in\nthe DNA coatings of micrometre-sized particles gives us in situ control\nover the inter-particle binding strength and association kinetics. We\ncan finely tune and even switch off the attractions between particles,\nrendering them inert unless they are heated or held together-like a\nnano-contact glue. The novel kinetic control offered by the switchable\nself-protected attractions is explained with a simple quantitative model\nthat emphasizes the competition between intra- and inter-particle\nhybridization, and the practical utility is demonstrated by the assembly\nof designer clusters in concentrated suspensions. With self-protection,\nboth the suspension and assembly product are stable, whereas\nconventional attractive colloids would quickly aggregate. This\nremarkable functionality makes our self-protected colloids a novel\nmaterial that greatly extends the utility of DNA-functionalized systems,\nenabling more versatile, multi-stage assembly approaches.","bibtype":"article","author":"Leunissen, Mirjam E and Dreyfus, Remi and Cheong, Fook Chiong and Grier, David G and Sha, Roujie and Seeman, Nadrian C and Chaikin, Paul M","journal":"NATURE MATERIALS","number":"7","bibtex":"@article{\n title = {Switchable self-protected attractions in DNA-functionalized colloids},\n type = {article},\n year = {2009},\n identifiers = {[object Object]},\n pages = {590-595},\n volume = {8},\n month = {7},\n publisher = {NATURE PUBLISHING GROUP},\n city = {MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND},\n id = {11588d5b-898f-3e14-9dbe-ed1672a3cdf5},\n created = {2015-12-14T19:51:31.000Z},\n file_attached = {false},\n profile_id = {3187ec9d-0fcc-3ba2-91e0-3075df9b18c3},\n group_id = {d75e47fd-ff52-3a4b-bf1e-6ebc7e454352},\n last_modified = {2017-03-14T12:30:08.401Z},\n read = {false},\n starred = {false},\n authored = {false},\n confirmed = {true},\n hidden = {false},\n citation_key = {ISI:000267204600020},\n source_type = {article},\n user_context = {Article},\n private_publication = {false},\n abstract = {Surface functionalization with DNA is a powerful tool for guiding the\nself-assembly of nanometre- and micrometre-sized particles(1-11).\nComplementary `sticky ends' form specific inter-particle links and\nreproducibly bind at low temperature and unbind at high temperature.\nSurprisingly, the ability of single-stranded DNA to form folded\nsecondary structures has not been explored for controlling (nano)\ncolloidal assembly processes, despite its frequent use in DNA\nnanotechnology(12-14). Here, we show how loop and hairpin formation in\nthe DNA coatings of micrometre-sized particles gives us in situ control\nover the inter-particle binding strength and association kinetics. We\ncan finely tune and even switch off the attractions between particles,\nrendering them inert unless they are heated or held together-like a\nnano-contact glue. The novel kinetic control offered by the switchable\nself-protected attractions is explained with a simple quantitative model\nthat emphasizes the competition between intra- and inter-particle\nhybridization, and the practical utility is demonstrated by the assembly\nof designer clusters in concentrated suspensions. With self-protection,\nboth the suspension and assembly product are stable, whereas\nconventional attractive colloids would quickly aggregate. This\nremarkable functionality makes our self-protected colloids a novel\nmaterial that greatly extends the utility of DNA-functionalized systems,\nenabling more versatile, multi-stage assembly approaches.},\n bibtype = {article},\n author = {Leunissen, Mirjam E and Dreyfus, Remi and Cheong, Fook Chiong and Grier, David G and Sha, Roujie and Seeman, Nadrian C and Chaikin, Paul M},\n journal = {NATURE MATERIALS},\n number = {7}\n}","author_short":["Leunissen, M., E.","Dreyfus, R.","Cheong, F., C.","Grier, D., G.","Sha, R.","Seeman, N., C.","Chaikin, P., M."],"bibbaseid":"leunissen-dreyfus-cheong-grier-sha-seeman-chaikin-switchableselfprotectedattractionsindnafunctionalizedcolloids-2009","role":"author","urls":{},"downloads":0},"search_terms":["switchable","self","protected","attractions","dna","functionalized","colloids","leunissen","dreyfus","cheong","grier","sha","seeman","chaikin"],"keywords":[],"authorIDs":[]}