Efficacy and Safety of the Local Application of Mitomycin C to Recurrent Esophageal Strictures in Children. Ley, D., Bridenne, M., Gottrand, F., Lemale, J., Hauser, B., Lachaux, A., Rebouissoux, L., Viala, J., Fayoux, P., & Michaud, L. Journal of Pediatric Gastroenterology and Nutrition, 69(5):528–532, November, 2019. ![Efficacy and Safety of the Local Application of Mitomycin C to Recurrent Esophageal Strictures in Children [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex OBJECTIVES: Research on long-term use of mitomycin C (MC) for recurrent esophageal stenoses is limited. We assessed the long-term efficacy and safety of local application of MC for recurrent esophageal stenoses in children. METHODS: This was a retrospective study of 39 patients (17 girls) with a median age of 19.5 months (range: 2.4-196.0) at the time of MC application. The etiologies of stenosis were esophageal atresia (n = 25), caustic ingestion (n = 9), congenital esophageal stenosis (n = 3), and other causes (n = 2). Stenosis was single in 35 (90%) patients and multiple in 4 (10%). Before MC, patients underwent multiple repeated dilations (median: 3 dilations per child [range: 2-26]) over a median period of 7 months (range: 2.6-49.3). Treatment success was defined a priori as a reduction in the number of dilations over the same period from before to after the application of MC. RESULTS: For 26 (67%) patients, the application of MC was considered a success: 102 versus 17 dilatations (P \textless 0.0001). Sixteen (41%) patients never required additional dilation during the follow-up after MC application (median: 3.1 years [range: 0.6-8.5]). No complication related to MC was observed. Biopsies at the site of MC application were performed at maximal follow-up in 16 patients and revealed no dysplasia. Three factors were associated with success of MC: single stenosis, short stenosis, and esophageal atresia type III. CONCLUSIONS: This study is the largest series reported showing that topical application of MC is an efficient and safe treatment for recurrent esophageal stenosis in children.
@article{ley_efficacy_2019,
title = {Efficacy and {Safety} of the {Local} {Application} of {Mitomycin} {C} to {Recurrent} {Esophageal} {Strictures} in {Children}},
volume = {69},
issn = {1536-4801},
url = {https://pubmed.ncbi.nlm.nih.gov/31436711/},
doi = {10.1097/MPG.0000000000002445},
abstract = {OBJECTIVES: Research on long-term use of mitomycin C (MC) for recurrent esophageal stenoses is limited. We assessed the long-term efficacy and safety of local application of MC for recurrent esophageal stenoses in children.
METHODS: This was a retrospective study of 39 patients (17 girls) with a median age of 19.5 months (range: 2.4-196.0) at the time of MC application. The etiologies of stenosis were esophageal atresia (n = 25), caustic ingestion (n = 9), congenital esophageal stenosis (n = 3), and other causes (n = 2). Stenosis was single in 35 (90\%) patients and multiple in 4 (10\%). Before MC, patients underwent multiple repeated dilations (median: 3 dilations per child [range: 2-26]) over a median period of 7 months (range: 2.6-49.3). Treatment success was defined a priori as a reduction in the number of dilations over the same period from before to after the application of MC.
RESULTS: For 26 (67\%) patients, the application of MC was considered a success: 102 versus 17 dilatations (P {\textless} 0.0001). Sixteen (41\%) patients never required additional dilation during the follow-up after MC application (median: 3.1 years [range: 0.6-8.5]). No complication related to MC was observed. Biopsies at the site of MC application were performed at maximal follow-up in 16 patients and revealed no dysplasia. Three factors were associated with success of MC: single stenosis, short stenosis, and esophageal atresia type III.
CONCLUSIONS: This study is the largest series reported showing that topical application of MC is an efficient and safe treatment for recurrent esophageal stenosis in children.},
language = {eng},
number = {5},
journal = {Journal of Pediatric Gastroenterology and Nutrition},
author = {Ley, Delphine and Bridenne, Marie and Gottrand, Frédéric and Lemale, Julie and Hauser, Bruno and Lachaux, Alain and Rebouissoux, Laurent and Viala, Jérôme and Fayoux, Pierre and Michaud, Laurent},
month = nov,
year = {2019},
keywords = {Administration, Mucosal, Adolescent, Antibiotics, Antineoplastic, Child, Child, Preschool, Esophageal Stenosis, Esophagoscopy, Female, Humans, Infant, Male, Mitomycin, Postoperative Complications, Retrospective Studies},
pages = {528--532},
}
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METHODS: This was a retrospective study of 39 patients (17 girls) with a median age of 19.5 months (range: 2.4-196.0) at the time of MC application. The etiologies of stenosis were esophageal atresia (n = 25), caustic ingestion (n = 9), congenital esophageal stenosis (n = 3), and other causes (n = 2). Stenosis was single in 35 (90%) patients and multiple in 4 (10%). Before MC, patients underwent multiple repeated dilations (median: 3 dilations per child [range: 2-26]) over a median period of 7 months (range: 2.6-49.3). Treatment success was defined a priori as a reduction in the number of dilations over the same period from before to after the application of MC. RESULTS: For 26 (67%) patients, the application of MC was considered a success: 102 versus 17 dilatations (P \\textless 0.0001). Sixteen (41%) patients never required additional dilation during the follow-up after MC application (median: 3.1 years [range: 0.6-8.5]). No complication related to MC was observed. Biopsies at the site of MC application were performed at maximal follow-up in 16 patients and revealed no dysplasia. Three factors were associated with success of MC: single stenosis, short stenosis, and esophageal atresia type III. CONCLUSIONS: This study is the largest series reported showing that topical application of MC is an efficient and safe treatment for recurrent esophageal stenosis in children.","language":"eng","number":"5","journal":"Journal of Pediatric Gastroenterology and Nutrition","author":[{"propositions":[],"lastnames":["Ley"],"firstnames":["Delphine"],"suffixes":[]},{"propositions":[],"lastnames":["Bridenne"],"firstnames":["Marie"],"suffixes":[]},{"propositions":[],"lastnames":["Gottrand"],"firstnames":["Frédéric"],"suffixes":[]},{"propositions":[],"lastnames":["Lemale"],"firstnames":["Julie"],"suffixes":[]},{"propositions":[],"lastnames":["Hauser"],"firstnames":["Bruno"],"suffixes":[]},{"propositions":[],"lastnames":["Lachaux"],"firstnames":["Alain"],"suffixes":[]},{"propositions":[],"lastnames":["Rebouissoux"],"firstnames":["Laurent"],"suffixes":[]},{"propositions":[],"lastnames":["Viala"],"firstnames":["Jérôme"],"suffixes":[]},{"propositions":[],"lastnames":["Fayoux"],"firstnames":["Pierre"],"suffixes":[]},{"propositions":[],"lastnames":["Michaud"],"firstnames":["Laurent"],"suffixes":[]}],"month":"November","year":"2019","keywords":"Administration, Mucosal, Adolescent, Antibiotics, Antineoplastic, Child, Child, Preschool, Esophageal Stenosis, Esophagoscopy, Female, Humans, Infant, Male, Mitomycin, Postoperative Complications, Retrospective Studies","pages":"528–532","bibtex":"@article{ley_efficacy_2019,\n\ttitle = {Efficacy and {Safety} of the {Local} {Application} of {Mitomycin} {C} to {Recurrent} {Esophageal} {Strictures} in {Children}},\n\tvolume = {69},\n\tissn = {1536-4801},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/31436711/},\n\tdoi = {10.1097/MPG.0000000000002445},\n\tabstract = {OBJECTIVES: Research on long-term use of mitomycin C (MC) for recurrent esophageal stenoses is limited. We assessed the long-term efficacy and safety of local application of MC for recurrent esophageal stenoses in children.\nMETHODS: This was a retrospective study of 39 patients (17 girls) with a median age of 19.5 months (range: 2.4-196.0) at the time of MC application. The etiologies of stenosis were esophageal atresia (n = 25), caustic ingestion (n = 9), congenital esophageal stenosis (n = 3), and other causes (n = 2). Stenosis was single in 35 (90\\%) patients and multiple in 4 (10\\%). Before MC, patients underwent multiple repeated dilations (median: 3 dilations per child [range: 2-26]) over a median period of 7 months (range: 2.6-49.3). Treatment success was defined a priori as a reduction in the number of dilations over the same period from before to after the application of MC.\nRESULTS: For 26 (67\\%) patients, the application of MC was considered a success: 102 versus 17 dilatations (P {\\textless} 0.0001). Sixteen (41\\%) patients never required additional dilation during the follow-up after MC application (median: 3.1 years [range: 0.6-8.5]). No complication related to MC was observed. Biopsies at the site of MC application were performed at maximal follow-up in 16 patients and revealed no dysplasia. 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