@article{
 title = {Total Synthesis of rapamycin},
 type = {article},
 year = {2009},
 keywords = {Anticancer agents,Immunosuppressive agents,Macrocyclization,Natural products,Total synthesis},
 pages = {2874-2914},
 volume = {15},
 websites = {http://onlinelibrary.wiley.com/store/10.1002/chem.200801656/asset/2874_ftp.pdf?v=1&t=h66fxp71&s=17e1224c9c77aef48361320c71c9603a00466463},
 publisher = {Wiley-VCH Verlag GmbH & Co. KGaA},
 id = {6c91e401-ccbd-30a0-b766-9dfcadc8a194},
 created = {2015-10-07T14:20:51.000Z},
 file_attached = {true},
 profile_id = {64f7fb50-d000-335d-a02d-06c5f340a97a},
 last_modified = {2018-09-03T10:20:45.826Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 citation_key = {Ley2009},
 source_type = {Journal Article},
 notes = {<b>From Duplicate 2 (<i>Total synthesis of rapamycin</i> - Ley, Steven V; Tackett, Miles N; Maddess, Matthew L; Anderson, James C; Brennan, Paul E; Cappi, Michael W; Heer, Jag P; Helgen, Celine; Kori, Masakuni; Kouklovsky, Cyrille; Marsden, Stephen P; Norman, Joanne; Osborn, David P; Palomero, Maria A; Pavey, John B J; Pinel, Catherine; Robinson, Lesley A; Schnaubelt, Jurgen; Scott, James S; Spilling, Christopher D; Watanabe, Hidenori; Wesson, Kieron E; Willis, Michael C)<br/></b><br/>CAPLUS AN 2009:365301(Journal)},
 private_publication = {false},
 abstract = {For over 30 years, rapamycin has generated a sustained and intense interest from the scientific community as a result of its exceptional pharmacological properties and challenging structural features. In addition to its well known therapeutic value as a potent immunosuppressive agent, rapamycin and its derivatives have recently gained prominence for the treatment of a wide variety of other human malignancies. Herein we disclose full details of our extensive investigation into the synthesis of rapamycin that culminated in a new and convergent preparation featuring a macro-etherification/catechol-templating strategy for construction of the macrocyclic core of this natural product.},
 bibtype = {article},
 author = {Ley, Steven V. and Tackett, Miles N. and Maddess, Matthew L. and Anderson, James C. and Brennan, Paul E. and Cappi, Michael W. and Heer, Jag P. and Helgen, Céline and Kori, Masakuni and Kouklovsky, Cyrille and Marsden, Stephen P. and Norman, Joanne and Osborn, David P. and Palomero, María Á and Pavey, John B.J. and Pinel, Catherine and Robinson, Lesley A. and Schnaubelt, Jürgen and Scott, James S. and Spilling, Christopher D. and Watanabe, Hidenori and Wesson, Kieron E. and Willis, Michael C.},
 doi = {10.1002/chem.200801656},
 journal = {Chemistry - A European Journal},
 number = {12}
}

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