Cationic Glycopolymers with Aggregation-Induced Emission for the Killing, Imaging, and Detection of Bacteria. Li, D., Chen, J., Hong, M., Wang, Y., Haddleton, D. M., Li, G., & Zhang, Q. BIOMACROMOLECULES, 22(5):2224–2232, May, 2021. doi abstract bibtex Cationic glycopolymers with structures similar to those of typical poly(ionic liquids (PILs) were synthesized via the quaternization reaction of poly(4-vinyl pyridine) with halogen-functionalized D-mannose and tetraphenylethylene units. Such postpolymerization modification provided PILs with aggregation-induced emission effect as well as specific carbohydrate-protein recognition with lectins such as concanavalin A. The interactions between cationic glycopolymers and different microorganisms, including Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli, were used for the killing, imaging, and detection of bacteria. Besides, these sugar-containing PILs showed a relatively low hemolysis rate due to the presence of saccharide units, which may have potential application in the field of biomaterials.
@article{li_cationic_2021,
title = {Cationic {Glycopolymers} with {Aggregation}-{Induced} {Emission} for the {Killing}, {Imaging}, and {Detection} of {Bacteria}},
volume = {22},
issn = {1525-7797},
doi = {10.1021/acs.biomac.1c00298},
abstract = {Cationic glycopolymers with structures similar to those of typical poly(ionic liquids (PILs) were synthesized via the quaternization reaction of poly(4-vinyl pyridine) with halogen-functionalized D-mannose and tetraphenylethylene units. Such postpolymerization modification provided PILs with aggregation-induced emission effect as well as specific carbohydrate-protein recognition with lectins such as concanavalin A. The interactions between cationic glycopolymers and different microorganisms, including Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli, were used for the killing, imaging, and detection of bacteria. Besides, these sugar-containing PILs showed a relatively low hemolysis rate due to the presence of saccharide units, which may have potential application in the field of biomaterials.},
number = {5},
urldate = {2021-06-05},
journal = {BIOMACROMOLECULES},
author = {Li, Die and Chen, Jing and Hong, Mei and Wang, Yan and Haddleton, David M. and Li, Guang-Zhao and Zhang, Qiang},
month = may,
year = {2021},
pages = {2224--2232},
}
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