Identification of novel HLA-A11-restricted T-cell epitopes in the Ebola virus nucleoprotein. Li, D., Li, P., Song, N., Jiang, Y., Zeng, Y., Zhao, G., Fa, Y., Ye, H., Lone, Y., Zhou, Y., Sun, S., & Zeng, L. Microbes and Infection, May, 2018. doi abstract bibtex The Ebola virus (EBOV) is a very contagious virus that is highly fatal in humans and animals. The largest epidemic was in West Africa in 2014, in which over 11,000 people died. However, to date, there are no licensed vaccines against it. Studies show that CD4+ and CD8+ T-cell responses, especially cytotoxic T-lymphocyte (CTL) responses, play key roles in protecting individuals from EBOV infection. Since HLA-restricted epitope vaccines are likely to be effective and safe immunization strategies for infectious diseases, the present study screened for CTL epitopes in the EBOV-nucleoprotein that are restricted by HLA-A11 (a common allele in Chinese people). Predictive computer analysis of the amino-acid sequence of EBOV-nucleoprotein identified ten putative HLA-A11-restricted epitopes. ELISPOT assay of immunized HLA-A11/DR1 transgenic mice showed that five (GR-9, VR-9, EK-9, PK-9, and RK-9) induced effective CTL responses. Additional epitope analyses will aid the design of epitope vaccines against EBOV.
@article{li_identification_2018,
title = {Identification of novel {HLA}-{A11}-restricted {T}-cell epitopes in the {Ebola} virus nucleoprotein},
issn = {1769-714X},
doi = {10.1016/j.micinf.2018.04.005},
abstract = {The Ebola virus (EBOV) is a very contagious virus that is highly fatal in humans and animals. The largest epidemic was in West Africa in 2014, in which over 11,000 people died. However, to date, there are no licensed vaccines against it. Studies show that CD4+ and CD8+ T-cell responses, especially cytotoxic T-lymphocyte (CTL) responses, play key roles in protecting individuals from EBOV infection. Since HLA-restricted epitope vaccines are likely to be effective and safe immunization strategies for infectious diseases, the present study screened for CTL epitopes in the EBOV-nucleoprotein that are restricted by HLA-A11 (a common allele in Chinese people). Predictive computer analysis of the amino-acid sequence of EBOV-nucleoprotein identified ten putative HLA-A11-restricted epitopes. ELISPOT assay of immunized HLA-A11/DR1 transgenic mice showed that five (GR-9, VR-9, EK-9, PK-9, and RK-9) induced effective CTL responses. Additional epitope analyses will aid the design of epitope vaccines against EBOV.},
language = {eng},
journal = {Microbes and Infection},
author = {Li, Dan and Li, Pei and Song, Nianping and Jiang, Yuting and Zeng, Yang and Zhao, Guangyu and Fa, Yunzhi and Ye, Huahu and Lone, Yuchun and Zhou, Yusen and Sun, Shihui and Zeng, Lin},
month = may,
year = {2018},
pmid = {29775667},
keywords = {Ebola virus, HLA-A11-restricted epitope, Vaccine},
}
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Since HLA-restricted epitope vaccines are likely to be effective and safe immunization strategies for infectious diseases, the present study screened for CTL epitopes in the EBOV-nucleoprotein that are restricted by HLA-A11 (a common allele in Chinese people). Predictive computer analysis of the amino-acid sequence of EBOV-nucleoprotein identified ten putative HLA-A11-restricted epitopes. ELISPOT assay of immunized HLA-A11/DR1 transgenic mice showed that five (GR-9, VR-9, EK-9, PK-9, and RK-9) induced effective CTL responses. Additional epitope analyses will aid the design of epitope vaccines against EBOV.","language":"eng","journal":"Microbes and Infection","author":[{"propositions":[],"lastnames":["Li"],"firstnames":["Dan"],"suffixes":[]},{"propositions":[],"lastnames":["Li"],"firstnames":["Pei"],"suffixes":[]},{"propositions":[],"lastnames":["Song"],"firstnames":["Nianping"],"suffixes":[]},{"propositions":[],"lastnames":["Jiang"],"firstnames":["Yuting"],"suffixes":[]},{"propositions":[],"lastnames":["Zeng"],"firstnames":["Yang"],"suffixes":[]},{"propositions":[],"lastnames":["Zhao"],"firstnames":["Guangyu"],"suffixes":[]},{"propositions":[],"lastnames":["Fa"],"firstnames":["Yunzhi"],"suffixes":[]},{"propositions":[],"lastnames":["Ye"],"firstnames":["Huahu"],"suffixes":[]},{"propositions":[],"lastnames":["Lone"],"firstnames":["Yuchun"],"suffixes":[]},{"propositions":[],"lastnames":["Zhou"],"firstnames":["Yusen"],"suffixes":[]},{"propositions":[],"lastnames":["Sun"],"firstnames":["Shihui"],"suffixes":[]},{"propositions":[],"lastnames":["Zeng"],"firstnames":["Lin"],"suffixes":[]}],"month":"May","year":"2018","pmid":"29775667","keywords":"Ebola virus, HLA-A11-restricted epitope, Vaccine","bibtex":"@article{li_identification_2018,\n\ttitle = {Identification of novel {HLA}-{A11}-restricted {T}-cell epitopes in the {Ebola} virus nucleoprotein},\n\tissn = {1769-714X},\n\tdoi = {10.1016/j.micinf.2018.04.005},\n\tabstract = {The Ebola virus (EBOV) is a very contagious virus that is highly fatal in humans and animals. The largest epidemic was in West Africa in 2014, in which over 11,000 people died. However, to date, there are no licensed vaccines against it. Studies show that CD4+ and CD8+ T-cell responses, especially cytotoxic T-lymphocyte (CTL) responses, play key roles in protecting individuals from EBOV infection. Since HLA-restricted epitope vaccines are likely to be effective and safe immunization strategies for infectious diseases, the present study screened for CTL epitopes in the EBOV-nucleoprotein that are restricted by HLA-A11 (a common allele in Chinese people). Predictive computer analysis of the amino-acid sequence of EBOV-nucleoprotein identified ten putative HLA-A11-restricted epitopes. ELISPOT assay of immunized HLA-A11/DR1 transgenic mice showed that five (GR-9, VR-9, EK-9, PK-9, and RK-9) induced effective CTL responses. 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