A tissue-like neurotransmitter sensor for the brain and gut. Li, J., Liu, Y., Yuan, L., Zhang, B., Bishop, E. S., Wang, K., Tang, J., Zheng, Y., Xu, W., Niu, S., Beker, L., Li, T. L., Chen, G., Diyaolu, M., Thomas, A., Mottini, V., Tok, J. B., Dunn, J. C. Y., Cui, B., Pașca, S. P., Cui, Y., Habtezion, A., Chen, X., & Bao, Z. Nature, 606(7912):94–101, Nature Publishing Group, June, 2022. ![A tissue-like neurotransmitter sensor for the brain and gut [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Neurotransmitters play essential roles in regulating neural circuit dynamics both in the central nervous system as well as at the peripheral, including the gastrointestinal tract1–3. Their real-time monitoring will offer critical information for understanding neural function and diagnosing disease1–3. However, bioelectronic tools to monitor the dynamics of neurotransmitters in vivo, especially in the enteric nervous systems, are underdeveloped. This is mainly owing to the limited availability of biosensing tools that are capable of examining soft, complex and actively moving organs. Here we introduce a tissue-mimicking, stretchable, neurochemical biological interface termed NeuroString, which is prepared by laser patterning of a metal-complexed polyimide into an interconnected graphene/nanoparticle network embedded in an elastomer. NeuroString sensors allow chronic in vivo real-time, multichannel and multiplexed monoamine sensing in the brain of behaving mouse, as well as measuring serotonin dynamics in the gut without undesired stimulations and perturbing peristaltic movements. The described elastic and conformable biosensing interface has broad potential for studying the impact of neurotransmitters on gut microbes, brain–gut communication and may ultimately be extended to biomolecular sensing in other soft organs across the body.
@article{li_tissue-like_2022,
title = {A tissue-like neurotransmitter sensor for the brain and gut},
volume = {606},
copyright = {2022 The Author(s), under exclusive licence to Springer Nature Limited},
issn = {1476-4687},
url = {https://www.nature.com/articles/s41586-022-04615-2},
doi = {10.1038/s41586-022-04615-2},
abstract = {Neurotransmitters play essential roles in regulating neural circuit dynamics both in the central nervous system as well as at the peripheral, including the gastrointestinal tract1–3. Their real-time monitoring will offer critical information for understanding neural function and diagnosing disease1–3. However, bioelectronic tools to monitor the dynamics of neurotransmitters in vivo, especially in the enteric nervous systems, are underdeveloped. This is mainly owing to the limited availability of biosensing tools that are capable of examining soft, complex and actively moving organs. Here we introduce a tissue-mimicking, stretchable, neurochemical biological interface termed NeuroString, which is prepared by laser patterning of a metal-complexed polyimide into an interconnected graphene/nanoparticle network embedded in an elastomer. NeuroString sensors allow chronic in vivo real-time, multichannel and multiplexed monoamine sensing in the brain of behaving mouse, as well as measuring serotonin dynamics in the gut without undesired stimulations and perturbing peristaltic movements. The described elastic and conformable biosensing interface has broad potential for studying the impact of neurotransmitters on gut microbes, brain–gut communication and may ultimately be extended to biomolecular sensing in other soft organs across the body.},
language = {en},
number = {7912},
urldate = {2025-10-21},
journal = {Nature},
publisher = {Nature Publishing Group},
author = {Li, Jinxing and Liu, Yuxin and Yuan, Lei and Zhang, Baibing and Bishop, Estelle Spear and Wang, Kecheng and Tang, Jing and Zheng, Yu-Qing and Xu, Wenhui and Niu, Simiao and Beker, Levent and Li, Thomas L. and Chen, Gan and Diyaolu, Modupeola and Thomas, Anne-Laure and Mottini, Vittorio and Tok, Jeffrey B.-H. and Dunn, James C. Y. and Cui, Bianxiao and Pașca, Sergiu P. and Cui, Yi and Habtezion, Aida and Chen, Xiaoke and Bao, Zhenan},
month = jun,
year = {2022},
keywords = {Sensors and probes, Soft materials},
pages = {94--101},
}
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