Stabilizing parallel G-quadruplex DNA by a new class of ligands: two non-planar alkaloids through interaction in lateral grooves. Li, Q., Xiang, J., Li, X., Chen, L., Xu, X., Tang, Y., Zhou, Q., Li, L., Zhang, H., Sun, H., Guan, A., Yang, Q., Yang, S., & Xu, G. Biochimie, 91(7):811–9, July, 2009. Publisher: Elsevier Masson SAS![Stabilizing parallel G-quadruplex DNA by a new class of ligands: two non-planar alkaloids through interaction in lateral grooves. [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Human DNA sequences consisting of tandem guanine (G) nucleotides can fold into a four-stranded structure named G-quadruplex via Hoogsteen hydrogen bonding. As the sequences forming G-quadruplex exist in essential regions of eukaryotic chromosomes and are involved in many important biological processes, the study of their biological functions has currently become a hotspot. Compounds selectively binding and stabilizing G-quadruplex structures have the potential to inhibit telomerase activity or alter oncogene expression levels and thus may act as antitumor agents. Most of reported G-quadruplex ligands generally have planar structures which stabilize G-quadruplex by pi-pi stacking. However, based on a pharmacophore-based virtual screening two non-planar G-quadruplex ligands were found. These two ligands exhibit good capability for G-quadruplex stabilization and prefer binding to paralleled G-quadruplex rather than to duplex DNA. The binding of these ligands to G-quadruplex may result from groove binding at a 2:1 stoichiometry. These results have shown that planar structures are not essential for G-quadruplex stabilizers, which may represent a new class of G-quadruplex-targeted agents as potential antitumor drugs.
@article{Li2009,
title = {Stabilizing parallel {G}-quadruplex {DNA} by a new class of ligands: two non-planar alkaloids through interaction in lateral grooves.},
volume = {91},
issn = {1638-6183},
url = {http://www.ncbi.nlm.nih.gov/pubmed/19318115},
doi = {10.1016/j.biochi.2009.03.007},
abstract = {Human DNA sequences consisting of tandem guanine (G) nucleotides can fold into a four-stranded structure named G-quadruplex via Hoogsteen hydrogen bonding. As the sequences forming G-quadruplex exist in essential regions of eukaryotic chromosomes and are involved in many important biological processes, the study of their biological functions has currently become a hotspot. Compounds selectively binding and stabilizing G-quadruplex structures have the potential to inhibit telomerase activity or alter oncogene expression levels and thus may act as antitumor agents. Most of reported G-quadruplex ligands generally have planar structures which stabilize G-quadruplex by pi-pi stacking. However, based on a pharmacophore-based virtual screening two non-planar G-quadruplex ligands were found. These two ligands exhibit good capability for G-quadruplex stabilization and prefer binding to paralleled G-quadruplex rather than to duplex DNA. The binding of these ligands to G-quadruplex may result from groove binding at a 2:1 stoichiometry. These results have shown that planar structures are not essential for G-quadruplex stabilizers, which may represent a new class of G-quadruplex-targeted agents as potential antitumor drugs.},
number = {7},
journal = {Biochimie},
author = {Li, Qian and Xiang, Junfeng and Li, Xudong and Chen, Lirong and Xu, Xiaojie and Tang, Yalin and Zhou, Qiuju and Li, Lin and Zhang, Hong and Sun, Hongxia and Guan, Aijiao and Yang, Qianfan and Yang, Shu and Xu, Guangzhi},
month = jul,
year = {2009},
pmid = {19318115},
note = {Publisher: Elsevier Masson SAS},
keywords = {\#nosource, Alkaloids, Alkaloids: chemistry, Alkaloids: metabolism, Biomolecular, Cevanes, Cevanes: chemistry, Cevanes: metabolism, G-Quadruplexes, Humans, Ligands, Models, Molecular, Nuclear Magnetic Resonance, Nucleic Acid Conformation, Structure-Activity Relationship},
pages = {811--9},
}
Downloads: 0
{"_id":"8cDxKzsebKY9SLkK3","bibbaseid":"li-xiang-li-chen-xu-tang-zhou-li-etal-stabilizingparallelgquadruplexdnabyanewclassofligandstwononplanaralkaloidsthroughinteractioninlateralgrooves-2009","author_short":["Li, Q.","Xiang, J.","Li, X.","Chen, L.","Xu, X.","Tang, Y.","Zhou, Q.","Li, L.","Zhang, H.","Sun, H.","Guan, A.","Yang, Q.","Yang, S.","Xu, G."],"bibdata":{"bibtype":"article","type":"article","title":"Stabilizing parallel G-quadruplex DNA by a new class of ligands: two non-planar alkaloids through interaction in lateral grooves.","volume":"91","issn":"1638-6183","url":"http://www.ncbi.nlm.nih.gov/pubmed/19318115","doi":"10.1016/j.biochi.2009.03.007","abstract":"Human DNA sequences consisting of tandem guanine (G) nucleotides can fold into a four-stranded structure named G-quadruplex via Hoogsteen hydrogen bonding. As the sequences forming G-quadruplex exist in essential regions of eukaryotic chromosomes and are involved in many important biological processes, the study of their biological functions has currently become a hotspot. Compounds selectively binding and stabilizing G-quadruplex structures have the potential to inhibit telomerase activity or alter oncogene expression levels and thus may act as antitumor agents. Most of reported G-quadruplex ligands generally have planar structures which stabilize G-quadruplex by pi-pi stacking. However, based on a pharmacophore-based virtual screening two non-planar G-quadruplex ligands were found. These two ligands exhibit good capability for G-quadruplex stabilization and prefer binding to paralleled G-quadruplex rather than to duplex DNA. The binding of these ligands to G-quadruplex may result from groove binding at a 2:1 stoichiometry. These results have shown that planar structures are not essential for G-quadruplex stabilizers, which may represent a new class of G-quadruplex-targeted agents as potential antitumor drugs.","number":"7","journal":"Biochimie","author":[{"propositions":[],"lastnames":["Li"],"firstnames":["Qian"],"suffixes":[]},{"propositions":[],"lastnames":["Xiang"],"firstnames":["Junfeng"],"suffixes":[]},{"propositions":[],"lastnames":["Li"],"firstnames":["Xudong"],"suffixes":[]},{"propositions":[],"lastnames":["Chen"],"firstnames":["Lirong"],"suffixes":[]},{"propositions":[],"lastnames":["Xu"],"firstnames":["Xiaojie"],"suffixes":[]},{"propositions":[],"lastnames":["Tang"],"firstnames":["Yalin"],"suffixes":[]},{"propositions":[],"lastnames":["Zhou"],"firstnames":["Qiuju"],"suffixes":[]},{"propositions":[],"lastnames":["Li"],"firstnames":["Lin"],"suffixes":[]},{"propositions":[],"lastnames":["Zhang"],"firstnames":["Hong"],"suffixes":[]},{"propositions":[],"lastnames":["Sun"],"firstnames":["Hongxia"],"suffixes":[]},{"propositions":[],"lastnames":["Guan"],"firstnames":["Aijiao"],"suffixes":[]},{"propositions":[],"lastnames":["Yang"],"firstnames":["Qianfan"],"suffixes":[]},{"propositions":[],"lastnames":["Yang"],"firstnames":["Shu"],"suffixes":[]},{"propositions":[],"lastnames":["Xu"],"firstnames":["Guangzhi"],"suffixes":[]}],"month":"July","year":"2009","pmid":"19318115","note":"Publisher: Elsevier Masson SAS","keywords":"#nosource, Alkaloids, Alkaloids: chemistry, Alkaloids: metabolism, Biomolecular, Cevanes, Cevanes: chemistry, Cevanes: metabolism, G-Quadruplexes, Humans, Ligands, Models, Molecular, Nuclear Magnetic Resonance, Nucleic Acid Conformation, Structure-Activity Relationship","pages":"811–9","bibtex":"@article{Li2009,\n\ttitle = {Stabilizing parallel {G}-quadruplex {DNA} by a new class of ligands: two non-planar alkaloids through interaction in lateral grooves.},\n\tvolume = {91},\n\tissn = {1638-6183},\n\turl = {http://www.ncbi.nlm.nih.gov/pubmed/19318115},\n\tdoi = {10.1016/j.biochi.2009.03.007},\n\tabstract = {Human DNA sequences consisting of tandem guanine (G) nucleotides can fold into a four-stranded structure named G-quadruplex via Hoogsteen hydrogen bonding. As the sequences forming G-quadruplex exist in essential regions of eukaryotic chromosomes and are involved in many important biological processes, the study of their biological functions has currently become a hotspot. Compounds selectively binding and stabilizing G-quadruplex structures have the potential to inhibit telomerase activity or alter oncogene expression levels and thus may act as antitumor agents. Most of reported G-quadruplex ligands generally have planar structures which stabilize G-quadruplex by pi-pi stacking. However, based on a pharmacophore-based virtual screening two non-planar G-quadruplex ligands were found. These two ligands exhibit good capability for G-quadruplex stabilization and prefer binding to paralleled G-quadruplex rather than to duplex DNA. The binding of these ligands to G-quadruplex may result from groove binding at a 2:1 stoichiometry. These results have shown that planar structures are not essential for G-quadruplex stabilizers, which may represent a new class of G-quadruplex-targeted agents as potential antitumor drugs.},\n\tnumber = {7},\n\tjournal = {Biochimie},\n\tauthor = {Li, Qian and Xiang, Junfeng and Li, Xudong and Chen, Lirong and Xu, Xiaojie and Tang, Yalin and Zhou, Qiuju and Li, Lin and Zhang, Hong and Sun, Hongxia and Guan, Aijiao and Yang, Qianfan and Yang, Shu and Xu, Guangzhi},\n\tmonth = jul,\n\tyear = {2009},\n\tpmid = {19318115},\n\tnote = {Publisher: Elsevier Masson SAS},\n\tkeywords = {\\#nosource, Alkaloids, Alkaloids: chemistry, Alkaloids: metabolism, Biomolecular, Cevanes, Cevanes: chemistry, Cevanes: metabolism, G-Quadruplexes, Humans, Ligands, Models, Molecular, Nuclear Magnetic Resonance, Nucleic Acid Conformation, Structure-Activity Relationship},\n\tpages = {811--9},\n}\n\n","author_short":["Li, Q.","Xiang, J.","Li, X.","Chen, L.","Xu, X.","Tang, Y.","Zhou, Q.","Li, L.","Zhang, H.","Sun, H.","Guan, A.","Yang, Q.","Yang, S.","Xu, G."],"key":"Li2009","id":"Li2009","bibbaseid":"li-xiang-li-chen-xu-tang-zhou-li-etal-stabilizingparallelgquadruplexdnabyanewclassofligandstwononplanaralkaloidsthroughinteractioninlateralgrooves-2009","role":"author","urls":{"Paper":"http://www.ncbi.nlm.nih.gov/pubmed/19318115"},"keyword":["#nosource","Alkaloids","Alkaloids: chemistry","Alkaloids: metabolism","Biomolecular","Cevanes","Cevanes: chemistry","Cevanes: metabolism","G-Quadruplexes","Humans","Ligands","Models","Molecular","Nuclear Magnetic Resonance","Nucleic Acid Conformation","Structure-Activity Relationship"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://bibbase.org/zotero/eric.larG4","dataSources":["4i5C7S78DvJNsaHyg","5L2zM5wNE5CBYNuea"],"keywords":["#nosource","alkaloids","alkaloids: chemistry","alkaloids: metabolism","biomolecular","cevanes","cevanes: chemistry","cevanes: metabolism","g-quadruplexes","humans","ligands","models","molecular","nuclear magnetic resonance","nucleic acid conformation","structure-activity relationship"],"search_terms":["stabilizing","parallel","quadruplex","dna","new","class","ligands","two","non","planar","alkaloids","through","interaction","lateral","grooves","li","xiang","li","chen","xu","tang","zhou","li","zhang","sun","guan","yang","yang","xu"],"title":"Stabilizing parallel G-quadruplex DNA by a new class of ligands: two non-planar alkaloids through interaction in lateral grooves.","year":2009}