Conserved gene regulatory module specifies lateral neural borders across bilaterians. Li, Y., Zhao, D., Horie, T., Chen, G., Bao, H., Chen, S., Liu, W., Horie, R., Liang, T., Dong, B., Feng, Q., Tao, Q., & Liu, X. Proceedings of the National Academy of Sciences, 114(31):E6352–E6360, August, 2017. ![Conserved gene regulatory module specifies lateral neural borders across bilaterians [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex The lateral neural plate border (NPB), the neural part of the vertebrate neural border, is composed of central nervous system (CNS) progenitors and peripheral nervous system (PNS) progenitors. In invertebrates, PNS progenitors are also juxtaposed to the lateral boundary of the CNS. Whether there are conserved molecular mechanisms determining vertebrate and invertebrate lateral neural borders remains unclear. Using single-cell-resolution gene-expression profiling and genetic analysis, we present evidence that orthologs of the NPB specification module specify the invertebrate lateral neural border, which is composed of CNS and PNS progenitors. First, like in vertebrates, the conserved neuroectoderm lateral border specifier Msx/vab-15 specifies lateral neuroblasts in Caenorhabditis elegans . Second, orthologs of the vertebrate NPB specification module ( Msx/vab-15 , Pax3/7/pax-3 , and Zic/ref-2 ) are significantly enriched in worm lateral neuroblasts. In addition, like in other bilaterians, the expression domain of Msx/vab-15 is more lateral than those of Pax3/7/pax-3 and Zic/ref- 2 in C. elegans . Third, we show that Msx/vab-15 regulates the development of mechanosensory neurons derived from lateral neural progenitors in multiple invertebrate species, including C. elegans , Drosophila melanogaster , and Ciona intestinalis . We also identify a novel lateral neural border specifier, ZNF703/tlp-1 , which functions synergistically with Msx/vab- 15 in both C. elegans and Xenopus laevis . These data suggest a common origin of the molecular mechanism specifying lateral neural borders across bilaterians.
@article{li_conserved_2017,
title = {Conserved gene regulatory module specifies lateral neural borders across bilaterians},
volume = {114},
issn = {0027-8424, 1091-6490},
url = {http://www.pnas.org/lookup/doi/10.1073/pnas.1704194114},
doi = {10.1073/pnas.1704194114},
abstract = {The lateral neural plate border (NPB), the neural part of the vertebrate neural border, is composed of central nervous system (CNS) progenitors and peripheral nervous system (PNS) progenitors. In invertebrates, PNS progenitors are also juxtaposed to the lateral boundary of the CNS. Whether there are conserved molecular mechanisms determining vertebrate and invertebrate lateral neural borders remains unclear. Using single-cell-resolution gene-expression profiling and genetic analysis, we present evidence that orthologs of the NPB specification module specify the invertebrate lateral neural border, which is composed of CNS and PNS progenitors. First, like in vertebrates, the conserved neuroectoderm lateral border specifier
Msx/vab-15
specifies lateral neuroblasts in
Caenorhabditis elegans
. Second, orthologs of the vertebrate NPB specification module (
Msx/vab-15
,
Pax3/7/pax-3
, and
Zic/ref-2
) are significantly enriched in worm lateral neuroblasts. In addition, like in other bilaterians, the expression domain of
Msx/vab-15
is more lateral than those of
Pax3/7/pax-3
and
Zic/ref-
2 in
C. elegans
. Third, we show that
Msx/vab-15
regulates the development of mechanosensory neurons derived from lateral neural progenitors in multiple invertebrate species, including
C. elegans
,
Drosophila melanogaster
, and
Ciona intestinalis
. We also identify a novel lateral neural border specifier,
ZNF703/tlp-1
, which functions synergistically with
Msx/vab-
15 in both
C. elegans
and
Xenopus laevis
. These data suggest a common origin of the molecular mechanism specifying lateral neural borders across bilaterians.},
language = {en},
number = {31},
urldate = {2021-07-27},
journal = {Proceedings of the National Academy of Sciences},
author = {Li, Yongbin and Zhao, Di and Horie, Takeo and Chen, Geng and Bao, Hongcun and Chen, Siyu and Liu, Weihong and Horie, Ryoko and Liang, Tao and Dong, Biyu and Feng, Qianqian and Tao, Qinghua and Liu, Xiao},
month = aug,
year = {2017},
pages = {E6352--E6360},
}
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Whether there are conserved molecular mechanisms determining vertebrate and invertebrate lateral neural borders remains unclear. Using single-cell-resolution gene-expression profiling and genetic analysis, we present evidence that orthologs of the NPB specification module specify the invertebrate lateral neural border, which is composed of CNS and PNS progenitors. First, like in vertebrates, the conserved neuroectoderm lateral border specifier Msx/vab-15 specifies lateral neuroblasts in Caenorhabditis elegans . Second, orthologs of the vertebrate NPB specification module ( Msx/vab-15 , Pax3/7/pax-3 , and Zic/ref-2 ) are significantly enriched in worm lateral neuroblasts. In addition, like in other bilaterians, the expression domain of Msx/vab-15 is more lateral than those of Pax3/7/pax-3 and Zic/ref- 2 in C. elegans . Third, we show that Msx/vab-15 regulates the development of mechanosensory neurons derived from lateral neural progenitors in multiple invertebrate species, including C. elegans , Drosophila melanogaster , and Ciona intestinalis . We also identify a novel lateral neural border specifier, ZNF703/tlp-1 , which functions synergistically with Msx/vab- 15 in both C. elegans and Xenopus laevis . 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In invertebrates, PNS progenitors are also juxtaposed to the lateral boundary of the CNS. Whether there are conserved molecular mechanisms determining vertebrate and invertebrate lateral neural borders remains unclear. Using single-cell-resolution gene-expression profiling and genetic analysis, we present evidence that orthologs of the NPB specification module specify the invertebrate lateral neural border, which is composed of CNS and PNS progenitors. First, like in vertebrates, the conserved neuroectoderm lateral border specifier\n Msx/vab-15\n specifies lateral neuroblasts in\n Caenorhabditis elegans\n . Second, orthologs of the vertebrate NPB specification module (\n Msx/vab-15\n ,\n Pax3/7/pax-3\n , and\n Zic/ref-2\n ) are significantly enriched in worm lateral neuroblasts. In addition, like in other bilaterians, the expression domain of\n Msx/vab-15\n is more lateral than those of\n Pax3/7/pax-3\n and\n Zic/ref-\n 2 in\n C. elegans\n . Third, we show that\n Msx/vab-15\n regulates the development of mechanosensory neurons derived from lateral neural progenitors in multiple invertebrate species, including\n C. elegans\n ,\n Drosophila melanogaster\n , and\n Ciona intestinalis\n . We also identify a novel lateral neural border specifier,\n ZNF703/tlp-1\n , which functions synergistically with\n Msx/vab-\n 15 in both\n C. elegans\n and\n Xenopus laevis\n . 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