A scoping review of how early-stage knee osteoarthritis has been defined. Liew, J. W., King, L. K., Mahmoudian, A., Wang, Q., Atkinson, H. F., Flynn, D. B., Appleton, C. T., Englund, M., Haugen, I. K., Lohmander, L. S., Runhaar, J., Neogi, T., & Hawker, G. Osteoarthritis and Cartilage, 293(6):681–693, May, 2023. Number: 6![A scoping review of how early-stage knee osteoarthritis has been defined [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Background Early-stage knee osteoarthritis (KOA) classification criteria will enable consistent identification and trial recruitment of individuals with knee osteoarthritis (OA) at an earlier stage of the disease when interventions may be more effective. Toward this goal, we identified how early-stage KOA has been defined in the literature. Methods We performed a scoping literature review in PubMed, EMBASE, Cochrane, and Web of Science, including human studies where early-stage KOA was included as a study population or outcome. Extracted data included demographics, symptoms/history, examination, laboratory, imaging, performance-based measures, gross inspection/histopathologic domains, and the components of composite early-stage KOA definitions. Results Of 6142 articles identified, 211 were included in data synthesis. An early-stage KOA definition was used for study inclusion in 194 studies, to define study outcomes in 11 studies, and in the context of new criteria development or validation in six studies. The element most often used to define early-stage KOA was Kellgren–Lawrence (KL) grade (151 studies, 72%), followed by symptoms (118 studies, 56%), and demographic characteristics (73 studies, 35%); 14 studies (6%) used previously developed early-stage KOA composite criteria. Among studies defining early-stage KOA radiographically, 52 studies defined early-stage KOA by KL grade alone; of these 52, 44 (85%) studies included individuals with KL grade 2 or higher in their definitions. Conclusion Early-stage KOA is variably defined in the published literature. Most studies included KL grades of 2 or higher within their definitions, which reflects established or later-stage OA. These findings underscore the need to develop and validate classification criteria for early-stage KOA.
@article{liew_scoping_2023,
title = {A scoping review of how early-stage knee osteoarthritis has been defined},
volume = {293},
issn = {1063-4584},
url = {https://www.sciencedirect.com/science/article/pii/S1063458423007975},
doi = {10.1016/j.joca.2023.04.015},
abstract = {Background
Early-stage knee osteoarthritis (KOA) classification criteria will enable consistent identification and trial recruitment of individuals with knee osteoarthritis (OA) at an earlier stage of the disease when interventions may be more effective. Toward this goal, we identified how early-stage KOA has been defined in the literature.
Methods
We performed a scoping literature review in PubMed, EMBASE, Cochrane, and Web of Science, including human studies where early-stage KOA was included as a study population or outcome. Extracted data included demographics, symptoms/history, examination, laboratory, imaging, performance-based measures, gross inspection/histopathologic domains, and the components of composite early-stage KOA definitions.
Results
Of 6142 articles identified, 211 were included in data synthesis. An early-stage KOA definition was used for study inclusion in 194 studies, to define study outcomes in 11 studies, and in the context of new criteria development or validation in six studies. The element most often used to define early-stage KOA was Kellgren–Lawrence (KL) grade (151 studies, 72\%), followed by symptoms (118 studies, 56\%), and demographic characteristics (73 studies, 35\%); 14 studies (6\%) used previously developed early-stage KOA composite criteria. Among studies defining early-stage KOA radiographically, 52 studies defined early-stage KOA by KL grade alone; of these 52, 44 (85\%) studies included individuals with KL grade 2 or higher in their definitions.
Conclusion
Early-stage KOA is variably defined in the published literature. Most studies included KL grades of 2 or higher within their definitions, which reflects established or later-stage OA. These findings underscore the need to develop and validate classification criteria for early-stage KOA.},
language = {en},
number = {6},
urldate = {2023-06-07},
journal = {Osteoarthritis and Cartilage},
author = {Liew, Jean W. and King, Lauren K. and Mahmoudian, Armaghan and Wang, Qiuke and Atkinson, Hayden F. and Flynn, David B. and Appleton, C. Thomas and Englund, Martin and Haugen, Ida K. and Lohmander, L. Stefan and Runhaar, Jos and Neogi, Tuhina and Hawker, Gillian},
month = may,
year = {2023},
note = {Number: 6},
keywords = {Classification criteria, Early-stage osteoarthritis, Knee osteoarthritis, Osteoarthritis, Scoping review, Symptomatic knee osteoarthritis},
pages = {681--693},
}
Downloads: 0
{"_id":"frSnBjv86vaNvsB9x","bibbaseid":"liew-king-mahmoudian-wang-atkinson-flynn-appleton-englund-etal-ascopingreviewofhowearlystagekneeosteoarthritishasbeendefined-2023","author_short":["Liew, J. W.","King, L. K.","Mahmoudian, A.","Wang, Q.","Atkinson, H. F.","Flynn, D. B.","Appleton, C. T.","Englund, M.","Haugen, I. K.","Lohmander, L. S.","Runhaar, J.","Neogi, T.","Hawker, G."],"bibdata":{"bibtype":"article","type":"article","title":"A scoping review of how early-stage knee osteoarthritis has been defined","volume":"293","issn":"1063-4584","url":"https://www.sciencedirect.com/science/article/pii/S1063458423007975","doi":"10.1016/j.joca.2023.04.015","abstract":"Background Early-stage knee osteoarthritis (KOA) classification criteria will enable consistent identification and trial recruitment of individuals with knee osteoarthritis (OA) at an earlier stage of the disease when interventions may be more effective. Toward this goal, we identified how early-stage KOA has been defined in the literature. Methods We performed a scoping literature review in PubMed, EMBASE, Cochrane, and Web of Science, including human studies where early-stage KOA was included as a study population or outcome. Extracted data included demographics, symptoms/history, examination, laboratory, imaging, performance-based measures, gross inspection/histopathologic domains, and the components of composite early-stage KOA definitions. Results Of 6142 articles identified, 211 were included in data synthesis. An early-stage KOA definition was used for study inclusion in 194 studies, to define study outcomes in 11 studies, and in the context of new criteria development or validation in six studies. The element most often used to define early-stage KOA was Kellgren–Lawrence (KL) grade (151 studies, 72%), followed by symptoms (118 studies, 56%), and demographic characteristics (73 studies, 35%); 14 studies (6%) used previously developed early-stage KOA composite criteria. Among studies defining early-stage KOA radiographically, 52 studies defined early-stage KOA by KL grade alone; of these 52, 44 (85%) studies included individuals with KL grade 2 or higher in their definitions. Conclusion Early-stage KOA is variably defined in the published literature. Most studies included KL grades of 2 or higher within their definitions, which reflects established or later-stage OA. These findings underscore the need to develop and validate classification criteria for early-stage KOA.","language":"en","number":"6","urldate":"2023-06-07","journal":"Osteoarthritis and Cartilage","author":[{"propositions":[],"lastnames":["Liew"],"firstnames":["Jean","W."],"suffixes":[]},{"propositions":[],"lastnames":["King"],"firstnames":["Lauren","K."],"suffixes":[]},{"propositions":[],"lastnames":["Mahmoudian"],"firstnames":["Armaghan"],"suffixes":[]},{"propositions":[],"lastnames":["Wang"],"firstnames":["Qiuke"],"suffixes":[]},{"propositions":[],"lastnames":["Atkinson"],"firstnames":["Hayden","F."],"suffixes":[]},{"propositions":[],"lastnames":["Flynn"],"firstnames":["David","B."],"suffixes":[]},{"propositions":[],"lastnames":["Appleton"],"firstnames":["C.","Thomas"],"suffixes":[]},{"propositions":[],"lastnames":["Englund"],"firstnames":["Martin"],"suffixes":[]},{"propositions":[],"lastnames":["Haugen"],"firstnames":["Ida","K."],"suffixes":[]},{"propositions":[],"lastnames":["Lohmander"],"firstnames":["L.","Stefan"],"suffixes":[]},{"propositions":[],"lastnames":["Runhaar"],"firstnames":["Jos"],"suffixes":[]},{"propositions":[],"lastnames":["Neogi"],"firstnames":["Tuhina"],"suffixes":[]},{"propositions":[],"lastnames":["Hawker"],"firstnames":["Gillian"],"suffixes":[]}],"month":"May","year":"2023","note":"Number: 6","keywords":"Classification criteria, Early-stage osteoarthritis, Knee osteoarthritis, Osteoarthritis, Scoping review, Symptomatic knee osteoarthritis","pages":"681–693","bibtex":"@article{liew_scoping_2023,\n\ttitle = {A scoping review of how early-stage knee osteoarthritis has been defined},\n\tvolume = {293},\n\tissn = {1063-4584},\n\turl = {https://www.sciencedirect.com/science/article/pii/S1063458423007975},\n\tdoi = {10.1016/j.joca.2023.04.015},\n\tabstract = {Background\nEarly-stage knee osteoarthritis (KOA) classification criteria will enable consistent identification and trial recruitment of individuals with knee osteoarthritis (OA) at an earlier stage of the disease when interventions may be more effective. Toward this goal, we identified how early-stage KOA has been defined in the literature.\nMethods\nWe performed a scoping literature review in PubMed, EMBASE, Cochrane, and Web of Science, including human studies where early-stage KOA was included as a study population or outcome. Extracted data included demographics, symptoms/history, examination, laboratory, imaging, performance-based measures, gross inspection/histopathologic domains, and the components of composite early-stage KOA definitions.\nResults\nOf 6142 articles identified, 211 were included in data synthesis. An early-stage KOA definition was used for study inclusion in 194 studies, to define study outcomes in 11 studies, and in the context of new criteria development or validation in six studies. The element most often used to define early-stage KOA was Kellgren–Lawrence (KL) grade (151 studies, 72\\%), followed by symptoms (118 studies, 56\\%), and demographic characteristics (73 studies, 35\\%); 14 studies (6\\%) used previously developed early-stage KOA composite criteria. Among studies defining early-stage KOA radiographically, 52 studies defined early-stage KOA by KL grade alone; of these 52, 44 (85\\%) studies included individuals with KL grade 2 or higher in their definitions.\nConclusion\nEarly-stage KOA is variably defined in the published literature. Most studies included KL grades of 2 or higher within their definitions, which reflects established or later-stage OA. These findings underscore the need to develop and validate classification criteria for early-stage KOA.},\n\tlanguage = {en},\n\tnumber = {6},\n\turldate = {2023-06-07},\n\tjournal = {Osteoarthritis and Cartilage},\n\tauthor = {Liew, Jean W. and King, Lauren K. and Mahmoudian, Armaghan and Wang, Qiuke and Atkinson, Hayden F. and Flynn, David B. and Appleton, C. Thomas and Englund, Martin and Haugen, Ida K. and Lohmander, L. Stefan and Runhaar, Jos and Neogi, Tuhina and Hawker, Gillian},\n\tmonth = may,\n\tyear = {2023},\n\tnote = {Number: 6},\n\tkeywords = {Classification criteria, Early-stage osteoarthritis, Knee osteoarthritis, Osteoarthritis, Scoping review, Symptomatic knee osteoarthritis},\n\tpages = {681--693},\n}\n\n","author_short":["Liew, J. W.","King, L. K.","Mahmoudian, A.","Wang, Q.","Atkinson, H. F.","Flynn, D. B.","Appleton, C. T.","Englund, M.","Haugen, I. K.","Lohmander, L. S.","Runhaar, J.","Neogi, T.","Hawker, G."],"key":"liew_scoping_2023","id":"liew_scoping_2023","bibbaseid":"liew-king-mahmoudian-wang-atkinson-flynn-appleton-englund-etal-ascopingreviewofhowearlystagekneeosteoarthritishasbeendefined-2023","role":"author","urls":{"Paper":"https://www.sciencedirect.com/science/article/pii/S1063458423007975"},"keyword":["Classification criteria","Early-stage osteoarthritis","Knee osteoarthritis","Osteoarthritis","Scoping review","Symptomatic knee osteoarthritis"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://api.zotero.org/groups/5155143/items?key=IVTAjWy1U5EkGJqE2Z2qQCfh&format=bibtex&limit=100","dataSources":["7PYyrRz6AvkoBBchz","5jEuhQhgRx3py8LmG","LPTeGao77ndnG4Tks"],"keywords":["classification criteria","early-stage osteoarthritis","knee osteoarthritis","osteoarthritis","scoping review","symptomatic knee osteoarthritis"],"search_terms":["scoping","review","early","stage","knee","osteoarthritis","defined","liew","king","mahmoudian","wang","atkinson","flynn","appleton","englund","haugen","lohmander","runhaar","neogi","hawker"],"title":"A scoping review of how early-stage knee osteoarthritis has been defined","year":2023}