Intra-individual reaction time variability based on ex-Gaussian distribution as a potential endophenotype for attention-deficit/hyperactivity disorder. Lin, H., Hwang-Gu, S., & Gau, S S. Acta psychiatrica Scandinavica, January, 2015.
Paper doi abstract bibtex OBJECTIVE: Intra-individual variability in reaction time (IIV-RT), defined by standard deviation of RT (RTSD), is considered as an endophenotype for attention-deficit/hyperactivity disorder (ADHD). Ex-Gaussian distributions of RT, rather than RTSD, could better characterize moment-to-moment fluctuations in neuropsychological performance. However, data of response variability based on ex-Gaussian parameters as an endophenotypic candidate for ADHD are lacking. METHOD: We assessed 411 adolescents with clinically diagnosed ADHD based on the DSM-IV-TR criteria as probands, 138 unaffected siblings, and 138 healthy controls. The output parameters, mu, sigma, and tau, of an ex-Gaussian RT distribution were derived from the Conners' continuous performance test. Multi-level models controlling for sex, age, comorbidity, and use of methylphenidate were applied. RESULTS: Compared with unaffected siblings and controls, ADHD probands had elevated sigma value, omissions, commissions, and mean RT. Unaffected siblings formed an intermediate group in-between probands and controls in terms of tau value and RTSD. There was no between-group difference in mu value. Conforming to a context-dependent nature, unaffected siblings still had an intermediate tau value in-between probands and controls across different interstimulus intervals. CONCLUSION: Our findings suggest IIV-RT represented by tau may be a potential endophenotype for inquiry into genetic underpinnings of ADHD in the context of heterogeneity.
@article{lin_intra-individual_2015,
title = {Intra-individual reaction time variability based on ex-{Gaussian} distribution as a potential endophenotype for attention-deficit/hyperactivity disorder.},
issn = {1600-0447},
url = {http://www.ncbi.nlm.nih.gov/pubmed/25612058},
doi = {10.1111/acps.12393},
abstract = {OBJECTIVE: Intra-individual variability in reaction time (IIV-RT), defined by standard deviation of RT (RTSD), is considered as an endophenotype for attention-deficit/hyperactivity disorder (ADHD). Ex-Gaussian distributions of RT, rather than RTSD, could better characterize moment-to-moment fluctuations in neuropsychological performance. However, data of response variability based on ex-Gaussian parameters as an endophenotypic candidate for ADHD are lacking.
METHOD: We assessed 411 adolescents with clinically diagnosed ADHD based on the DSM-IV-TR criteria as probands, 138 unaffected siblings, and 138 healthy controls. The output parameters, mu, sigma, and tau, of an ex-Gaussian RT distribution were derived from the Conners' continuous performance test. Multi-level models controlling for sex, age, comorbidity, and use of methylphenidate were applied.
RESULTS: Compared with unaffected siblings and controls, ADHD probands had elevated sigma value, omissions, commissions, and mean RT. Unaffected siblings formed an intermediate group in-between probands and controls in terms of tau value and RTSD. There was no between-group difference in mu value. Conforming to a context-dependent nature, unaffected siblings still had an intermediate tau value in-between probands and controls across different interstimulus intervals.
CONCLUSION: Our findings suggest IIV-RT represented by tau may be a potential endophenotype for inquiry into genetic underpinnings of ADHD in the context of heterogeneity.},
urldate = {2015-05-18},
journal = {Acta psychiatrica Scandinavica},
author = {Lin, H-Y and Hwang-Gu, S-L and Gau, S S-F},
month = jan,
year = {2015},
pmid = {25612058},
}
Downloads: 0
{"_id":"7EepJnemTiHLQ5Ja4","bibbaseid":"lin-hwanggu-gau-intraindividualreactiontimevariabilitybasedonexgaussiandistributionasapotentialendophenotypeforattentiondeficithyperactivitydisorder-2015","author_short":["Lin, H.","Hwang-Gu, S.","Gau, S S."],"bibdata":{"bibtype":"article","type":"article","title":"Intra-individual reaction time variability based on ex-Gaussian distribution as a potential endophenotype for attention-deficit/hyperactivity disorder.","issn":"1600-0447","url":"http://www.ncbi.nlm.nih.gov/pubmed/25612058","doi":"10.1111/acps.12393","abstract":"OBJECTIVE: Intra-individual variability in reaction time (IIV-RT), defined by standard deviation of RT (RTSD), is considered as an endophenotype for attention-deficit/hyperactivity disorder (ADHD). Ex-Gaussian distributions of RT, rather than RTSD, could better characterize moment-to-moment fluctuations in neuropsychological performance. However, data of response variability based on ex-Gaussian parameters as an endophenotypic candidate for ADHD are lacking. METHOD: We assessed 411 adolescents with clinically diagnosed ADHD based on the DSM-IV-TR criteria as probands, 138 unaffected siblings, and 138 healthy controls. The output parameters, mu, sigma, and tau, of an ex-Gaussian RT distribution were derived from the Conners' continuous performance test. Multi-level models controlling for sex, age, comorbidity, and use of methylphenidate were applied. RESULTS: Compared with unaffected siblings and controls, ADHD probands had elevated sigma value, omissions, commissions, and mean RT. Unaffected siblings formed an intermediate group in-between probands and controls in terms of tau value and RTSD. There was no between-group difference in mu value. Conforming to a context-dependent nature, unaffected siblings still had an intermediate tau value in-between probands and controls across different interstimulus intervals. CONCLUSION: Our findings suggest IIV-RT represented by tau may be a potential endophenotype for inquiry into genetic underpinnings of ADHD in the context of heterogeneity.","urldate":"2015-05-18","journal":"Acta psychiatrica Scandinavica","author":[{"propositions":[],"lastnames":["Lin"],"firstnames":["H-Y"],"suffixes":[]},{"propositions":[],"lastnames":["Hwang-Gu"],"firstnames":["S-L"],"suffixes":[]},{"propositions":[],"lastnames":["Gau"],"firstnames":["S","S-F"],"suffixes":[]}],"month":"January","year":"2015","pmid":"25612058","bibtex":"@article{lin_intra-individual_2015,\n\ttitle = {Intra-individual reaction time variability based on ex-{Gaussian} distribution as a potential endophenotype for attention-deficit/hyperactivity disorder.},\n\tissn = {1600-0447},\n\turl = {http://www.ncbi.nlm.nih.gov/pubmed/25612058},\n\tdoi = {10.1111/acps.12393},\n\tabstract = {OBJECTIVE: Intra-individual variability in reaction time (IIV-RT), defined by standard deviation of RT (RTSD), is considered as an endophenotype for attention-deficit/hyperactivity disorder (ADHD). Ex-Gaussian distributions of RT, rather than RTSD, could better characterize moment-to-moment fluctuations in neuropsychological performance. However, data of response variability based on ex-Gaussian parameters as an endophenotypic candidate for ADHD are lacking.\n\nMETHOD: We assessed 411 adolescents with clinically diagnosed ADHD based on the DSM-IV-TR criteria as probands, 138 unaffected siblings, and 138 healthy controls. The output parameters, mu, sigma, and tau, of an ex-Gaussian RT distribution were derived from the Conners' continuous performance test. Multi-level models controlling for sex, age, comorbidity, and use of methylphenidate were applied.\n\nRESULTS: Compared with unaffected siblings and controls, ADHD probands had elevated sigma value, omissions, commissions, and mean RT. Unaffected siblings formed an intermediate group in-between probands and controls in terms of tau value and RTSD. There was no between-group difference in mu value. Conforming to a context-dependent nature, unaffected siblings still had an intermediate tau value in-between probands and controls across different interstimulus intervals.\n\nCONCLUSION: Our findings suggest IIV-RT represented by tau may be a potential endophenotype for inquiry into genetic underpinnings of ADHD in the context of heterogeneity.},\n\turldate = {2015-05-18},\n\tjournal = {Acta psychiatrica Scandinavica},\n\tauthor = {Lin, H-Y and Hwang-Gu, S-L and Gau, S S-F},\n\tmonth = jan,\n\tyear = {2015},\n\tpmid = {25612058},\n}\n\n","author_short":["Lin, H.","Hwang-Gu, S.","Gau, S S."],"key":"lin_intra-individual_2015","id":"lin_intra-individual_2015","bibbaseid":"lin-hwanggu-gau-intraindividualreactiontimevariabilitybasedonexgaussiandistributionasapotentialendophenotypeforattentiondeficithyperactivitydisorder-2015","role":"author","urls":{"Paper":"http://www.ncbi.nlm.nih.gov/pubmed/25612058"},"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://bibbase.org/zotero/asrommel","dataSources":["J8fbWsdsy3xAaB3pX"],"keywords":[],"search_terms":["intra","individual","reaction","time","variability","based","gaussian","distribution","potential","endophenotype","attention","deficit","hyperactivity","disorder","lin","hwang-gu","gau"],"title":"Intra-individual reaction time variability based on ex-Gaussian distribution as a potential endophenotype for attention-deficit/hyperactivity disorder.","year":2015}