EpiHealth: a large population-based cohort study for investigation of gene-lifestyle interactions in the pathogenesis of common diseases. Lind, L., Elmstahl, S., Bergman, E., Englund, M., Lindberg, E., Michaelsson, K., Nilsson, P. M., & Sundstrom, J. 28(2):189--197.
doi  abstract   bibtex   
The most common diseases affecting middle-aged and elderly subjects in industrialized countries are multigenetic and lifestyle related. Several attempts have been made to study interactions between genes and lifestyle factors, but most such studies lack the power to examine interactions between several genes and several lifestyle components. The primary objective of the EpiHealth cohort study is to provide a resource to study interactions between several genotypes and lifestyle factors in a large cohort (the aim is 300,000 individuals) derived from the Swedish population in the age range of 45-75 years regarding development of common degenerative disorders, such as cardiovascular diseases, cancer, dementia, joint pain, obstructive lung disease, depression, and osteoporotic fractures. The study consists of three parts. First, a collection of data on lifestyle factors by self-assessment using an internet-based questionnaire. Second, a visit to a test center where blood samples are collected and physiological parameters recorded. Third, the sample is followed for occurrence of outcomes using nationwide medical registers. This overview presents the study design and some baseline characteristics from the first year of data collection in the EpiHealth study.
@article{lind_epihealth:_2013,
	title = {{EpiHealth}: a large population-based cohort study for investigation of gene-lifestyle interactions in the pathogenesis of common diseases.},
	volume = {28},
	issn = {1573-7284 0393-2990},
	doi = {10.1007/s10654-013-9787-x},
	abstract = {The most common diseases affecting middle-aged and elderly subjects in industrialized countries are multigenetic and lifestyle related. Several attempts have been made to study interactions between genes and lifestyle factors, but most such studies lack the power to examine interactions between several genes and several lifestyle components. The primary objective of the {EpiHealth} cohort study is to provide a resource to study interactions between several genotypes and lifestyle factors in a large cohort (the aim is 300,000 individuals) derived  from the Swedish population in the age range of 45-75 years regarding development of common degenerative disorders, such as cardiovascular diseases, cancer, dementia, joint pain, obstructive lung disease, depression, and osteoporotic fractures. The study consists of three parts. First, a collection of data on lifestyle factors by self-assessment using an internet-based questionnaire. Second, a visit to a test center where blood samples are collected and physiological parameters recorded. Third, the sample is followed for occurrence of outcomes using nationwide medical registers. This overview presents the study  design and some baseline characteristics from the first year of data collection in the {EpiHealth} study.},
	pages = {189--197},
	number = {2},
	journaltitle = {European journal of epidemiology},
	shortjournal = {Eur J Epidemiol},
	author = {Lind, Lars and Elmstahl, Solve and Bergman, Ebba and Englund, Martin and Lindberg, Eva and Michaelsson, Karl and Nilsson, Peter M. and Sundstrom, Johan},
	date = {2013-02},
	pmid = {23435790},
	keywords = {*Genotype, *Life Style, Aged, Aged, 80 and over, Biomarkers/*blood, Chronic Disease/epidemiology/prevention \& control, Databases, Genetic, Disease/ethnology/*genetics, Female, Genetic Predisposition to Disease/*epidemiology, Health Status, Humans, Longitudinal Studies, Male, Middle Aged, Molecular Epidemiology, Population Surveillance, Risk Factors, Self-Assessment, Surveys and Questionnaires, Sweden/epidemiology}
}

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