High-resolution DNA quadruplex structure containing all the A-, G-, C-, T-tetrads. Liu, H., Wang, R., Yu, X., Shen, F., Lan, W., Haruehanroengra, P., Yao, Q., Zhang, J., Chen, Y., Li, S., Wu, B., Zheng, L., Ma, J., Lin, J., Cao, C., Li, J., Sheng, J., & Gan, J. Nucleic Acids Research, October, 2018. tex.ids= liuHighresolutionDNAQuadruplex2018 publisher: Oxford University Press![High-resolution DNA quadruplex structure containing all the A-, G-, C-, T-tetrads [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex DNA can form diverse structures, which predefine their physiological functions. Besides duplexes that carry the genetic information, quadruplexes are the most well-studied DNA structures. In addition to their important roles in recombination, replication, transcription and translation, DNA quadruplexes have also been applied as diagnostic aptamers and antidisease therapeutics. Herein we further expand the sequence and structure complexity of DNA quadruplex by presenting a high-resolution crystal structure of DNA1 (5'-AGAGAGATGGGTGCGTT-3'). This is the first quadruplex structure that contains all the internal A-, G-, C-, T-tetrads, A:T:A:T tetrads and bulged nucleotides in one single structure; as revealed by site-specific mutagenesis and biophysical studies, the central ATGGG motif plays important role in the quadruplex formation. Interestingly, our structure also provides great new insights into cation recognition, including the first-time reported Pb2+, by tetrad structures.
@article{Liu2018,
title = {High-resolution {DNA} quadruplex structure containing all the {A}-, {G}-, {C}-, {T}-tetrads},
issn = {0305-1048},
url = {https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gky902/5115218},
doi = {10.1093/nar/gky902},
abstract = {DNA can form diverse structures, which predefine their physiological functions. Besides duplexes that carry the genetic information, quadruplexes are the most well-studied DNA structures. In addition to their important roles in recombination, replication, transcription and translation, DNA quadruplexes have also been applied as diagnostic aptamers and antidisease therapeutics. Herein we further expand the sequence and structure complexity of DNA quadruplex by presenting a high-resolution crystal structure of DNA1 (5'-AGAGAGATGGGTGCGTT-3'). This is the first quadruplex structure that contains all the internal A-, G-, C-, T-tetrads, A:T:A:T tetrads and bulged nucleotides in one single structure; as revealed by site-specific mutagenesis and biophysical studies, the central ATGGG motif plays important role in the quadruplex formation. Interestingly, our structure also provides great new insights into cation recognition, including the first-time reported Pb2+, by tetrad structures.},
journal = {Nucleic Acids Research},
author = {Liu, Hehua and Wang, Rui and Yu, Xiang and Shen, Fusheng and Lan, Wenxian and Haruehanroengra, Phensinee and Yao, Qingqing and Zhang, Jing and Chen, Yiqing and Li, Suhua and Wu, Baixing and Zheng, Lina and Ma, Jinbiao and Lin, Jinzhong and Cao, Chunyang and Li, Jixi and Sheng, Jia and Gan, Jianhua},
month = oct,
year = {2018},
note = {tex.ids= liuHighresolutionDNAQuadruplex2018
publisher: Oxford University Press},
pages = {1--12},
}
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In addition to their important roles in recombination, replication, transcription and translation, DNA quadruplexes have also been applied as diagnostic aptamers and antidisease therapeutics. Herein we further expand the sequence and structure complexity of DNA quadruplex by presenting a high-resolution crystal structure of DNA1 (5'-AGAGAGATGGGTGCGTT-3'). This is the first quadruplex structure that contains all the internal A-, G-, C-, T-tetrads, A:T:A:T tetrads and bulged nucleotides in one single structure; as revealed by site-specific mutagenesis and biophysical studies, the central ATGGG motif plays important role in the quadruplex formation. 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Besides duplexes that carry the genetic information, quadruplexes are the most well-studied DNA structures. In addition to their important roles in recombination, replication, transcription and translation, DNA quadruplexes have also been applied as diagnostic aptamers and antidisease therapeutics. Herein we further expand the sequence and structure complexity of DNA quadruplex by presenting a high-resolution crystal structure of DNA1 (5'-AGAGAGATGGGTGCGTT-3'). This is the first quadruplex structure that contains all the internal A-, G-, C-, T-tetrads, A:T:A:T tetrads and bulged nucleotides in one single structure; as revealed by site-specific mutagenesis and biophysical studies, the central ATGGG motif plays important role in the quadruplex formation. 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