NF-κB signaling in inflammation. Liu, T., Zhang, L., Joo, D., & Sun, S. Signal Transduction and Targeted Therapy, 2(1):17023, July, 2017. ![NF-κB signaling in inflammation [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Abstract The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune functions and serves as a pivotal mediator of inflammatory responses. NF-κB induces the expression of various pro-inflammatory genes, including those encoding cytokines and chemokines, and also participates in inflammasome regulation. In addition, NF-κB plays a critical role in regulating the survival, activation and differentiation of innate immune cells and inflammatory T cells. Consequently, deregulated NF-κB activation contributes to the pathogenic processes of various inflammatory diseases. In this review, we will discuss the activation and function of NF-κB in association with inflammatory diseases and highlight the development of therapeutic strategies based on NF-κB inhibition.
@article{liu_nf-b_2017,
title = {{NF}-κ{B} signaling in inflammation},
volume = {2},
issn = {2059-3635},
url = {https://www.nature.com/articles/sigtrans201723},
doi = {10.1038/sigtrans.2017.23},
abstract = {Abstract
The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune functions and serves as a pivotal mediator of inflammatory responses. NF-κB induces the expression of various pro-inflammatory genes, including those encoding cytokines and chemokines, and also participates in inflammasome regulation. In addition, NF-κB plays a critical role in regulating the survival, activation and differentiation of innate immune cells and inflammatory T cells. Consequently, deregulated NF-κB activation contributes to the pathogenic processes of various inflammatory diseases. In this review, we will discuss the activation and function of NF-κB in association with inflammatory diseases and highlight the development of therapeutic strategies based on NF-κB inhibition.},
language = {en},
number = {1},
urldate = {2024-09-10},
journal = {Signal Transduction and Targeted Therapy},
author = {Liu, Ting and Zhang, Lingyun and Joo, Donghyun and Sun, Shao-Cong},
month = jul,
year = {2017},
pages = {17023},
}
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