Cluster analysis of obsessive-compulsive symptomatology: identifying obsessive-compulsive disorder subtypes. Lochner, C., Hemmings, S. M. J., Kinnear, C. J., Nel, D., Hemmings, S. M. J., Seedat, S., Moolman-Smook, J. C., & Stein, D. J. The Israel Journal of Psychiatry and Related Sciences, 45(3):164–176, 2008. 00025 abstract bibtex BACKGROUND: There is increasing evidence that obsessive-compulsive disorder (OCD) is a heterogeneous disorder. Different clinical subtypes may be characterized by differing pathophysiological mechanisms and treatment outcomes. METHODS: A cluster analysis was performed on 45 items of the Yale-Brown Obsessive-Compulsive Symptoms Checklist (YBOCS-CL) for 261 patients with OCD. Cluster solutions emerging at different linkage distance levels, and the associations of identified clusters with demographic, clinical and relevant genetic variables, were investigated. RESULTS: A 6-cluster solution emerged at a linkage distance level of 1.5, and a 3-cluster solution emerged at a linkage distance level of 2.1. The 3 clusters in the latter solution were labeled I) Contamination / washing, II) Hoarding / symmetry / ordering, and III) Obsessional / checking. Increased Cluster III scores were associated with earlier age of OCD onset and the Met/Met (L/L) genotype of the COMT Val158Met polymorphism. CONCLUSION: The data here are consistent with previous work delineating the different symptom subtypes of OCD, also with previous work suggesting that the Met/Met (L/L) genotype of the COMT Val158Met polymorphism may be associated with anxiety symptoms, as well as with previous work suggesting that dopaminergic genes may be particularly important in early-onset OCD.
@article{lochner_cluster_2008,
title = {Cluster analysis of obsessive-compulsive symptomatology: identifying obsessive-compulsive disorder subtypes},
volume = {45},
issn = {0333-7308},
shorttitle = {Cluster analysis of obsessive-compulsive symptomatology},
abstract = {BACKGROUND: There is increasing evidence that obsessive-compulsive disorder (OCD) is a heterogeneous disorder. Different clinical subtypes may be characterized by differing pathophysiological mechanisms and treatment outcomes.
METHODS: A cluster analysis was performed on 45 items of the Yale-Brown Obsessive-Compulsive Symptoms Checklist (YBOCS-CL) for 261 patients with OCD. Cluster solutions emerging at different linkage distance levels, and the associations of identified clusters with demographic, clinical and relevant genetic variables, were investigated.
RESULTS: A 6-cluster solution emerged at a linkage distance level of 1.5, and a 3-cluster solution emerged at a linkage distance level of 2.1. The 3 clusters in the latter solution were labeled I) Contamination / washing, II) Hoarding / symmetry / ordering, and III) Obsessional / checking. Increased Cluster III scores were associated with earlier age of OCD onset and the Met/Met (L/L) genotype of the COMT Val158Met polymorphism.
CONCLUSION: The data here are consistent with previous work delineating the different symptom subtypes of OCD, also with previous work suggesting that the Met/Met (L/L) genotype of the COMT Val158Met polymorphism may be associated with anxiety symptoms, as well as with previous work suggesting that dopaminergic genes may be particularly important in early-onset OCD.},
language = {eng},
number = {3},
journal = {The Israel Journal of Psychiatry and Related Sciences},
author = {Lochner, Christine and Hemmings, Sian M. J. and Kinnear, Craig J. and Nel, Daan and Hemmings, Sian M. J. and Seedat, Soraya and Moolman-Smook, Johanna C. and Stein, Dan J.},
year = {2008},
pmid = {19398820},
note = {00025 },
keywords = {Adolescent, Adult, Aged, Analysis of Variance, Catechol O-Methyltransferase, Cluster Analysis, Female, Genotype, Humans, Male, Middle Aged, Obsessive-Compulsive Disorder, Polymerase Chain Reaction, Polymorphism, Genetic, Polymorphism, Single Nucleotide, Young Adult},
pages = {164--176},
}
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J."],"year":2008,"bibtype":"article","biburl":"http://bibbase.org/zotero/TBHostGen","bibdata":{"bibtype":"article","type":"article","title":"Cluster analysis of obsessive-compulsive symptomatology: identifying obsessive-compulsive disorder subtypes","volume":"45","issn":"0333-7308","shorttitle":"Cluster analysis of obsessive-compulsive symptomatology","abstract":"BACKGROUND: There is increasing evidence that obsessive-compulsive disorder (OCD) is a heterogeneous disorder. Different clinical subtypes may be characterized by differing pathophysiological mechanisms and treatment outcomes. METHODS: A cluster analysis was performed on 45 items of the Yale-Brown Obsessive-Compulsive Symptoms Checklist (YBOCS-CL) for 261 patients with OCD. Cluster solutions emerging at different linkage distance levels, and the associations of identified clusters with demographic, clinical and relevant genetic variables, were investigated. RESULTS: A 6-cluster solution emerged at a linkage distance level of 1.5, and a 3-cluster solution emerged at a linkage distance level of 2.1. The 3 clusters in the latter solution were labeled I) Contamination / washing, II) Hoarding / symmetry / ordering, and III) Obsessional / checking. Increased Cluster III scores were associated with earlier age of OCD onset and the Met/Met (L/L) genotype of the COMT Val158Met polymorphism. CONCLUSION: The data here are consistent with previous work delineating the different symptom subtypes of OCD, also with previous work suggesting that the Met/Met (L/L) genotype of the COMT Val158Met polymorphism may be associated with anxiety symptoms, as well as with previous work suggesting that dopaminergic genes may be particularly important in early-onset OCD.","language":"eng","number":"3","journal":"The Israel Journal of Psychiatry and Related Sciences","author":[{"propositions":[],"lastnames":["Lochner"],"firstnames":["Christine"],"suffixes":[]},{"propositions":[],"lastnames":["Hemmings"],"firstnames":["Sian","M.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Kinnear"],"firstnames":["Craig","J."],"suffixes":[]},{"propositions":[],"lastnames":["Nel"],"firstnames":["Daan"],"suffixes":[]},{"propositions":[],"lastnames":["Hemmings"],"firstnames":["Sian","M.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Seedat"],"firstnames":["Soraya"],"suffixes":[]},{"propositions":[],"lastnames":["Moolman-Smook"],"firstnames":["Johanna","C."],"suffixes":[]},{"propositions":[],"lastnames":["Stein"],"firstnames":["Dan","J."],"suffixes":[]}],"year":"2008","pmid":"19398820","note":"00025 ","keywords":"Adolescent, Adult, Aged, Analysis of Variance, Catechol O-Methyltransferase, Cluster Analysis, Female, Genotype, Humans, Male, Middle Aged, Obsessive-Compulsive Disorder, Polymerase Chain Reaction, Polymorphism, Genetic, Polymorphism, Single Nucleotide, Young Adult","pages":"164–176","bibtex":"@article{lochner_cluster_2008,\n\ttitle = {Cluster analysis of obsessive-compulsive symptomatology: identifying obsessive-compulsive disorder subtypes},\n\tvolume = {45},\n\tissn = {0333-7308},\n\tshorttitle = {Cluster analysis of obsessive-compulsive symptomatology},\n\tabstract = {BACKGROUND: There is increasing evidence that obsessive-compulsive disorder (OCD) is a heterogeneous disorder. Different clinical subtypes may be characterized by differing pathophysiological mechanisms and treatment outcomes.\nMETHODS: A cluster analysis was performed on 45 items of the Yale-Brown Obsessive-Compulsive Symptoms Checklist (YBOCS-CL) for 261 patients with OCD. Cluster solutions emerging at different linkage distance levels, and the associations of identified clusters with demographic, clinical and relevant genetic variables, were investigated.\nRESULTS: A 6-cluster solution emerged at a linkage distance level of 1.5, and a 3-cluster solution emerged at a linkage distance level of 2.1. The 3 clusters in the latter solution were labeled I) Contamination / washing, II) Hoarding / symmetry / ordering, and III) Obsessional / checking. Increased Cluster III scores were associated with earlier age of OCD onset and the Met/Met (L/L) genotype of the COMT Val158Met polymorphism.\nCONCLUSION: The data here are consistent with previous work delineating the different symptom subtypes of OCD, also with previous work suggesting that the Met/Met (L/L) genotype of the COMT Val158Met polymorphism may be associated with anxiety symptoms, as well as with previous work suggesting that dopaminergic genes may be particularly important in early-onset OCD.},\n\tlanguage = {eng},\n\tnumber = {3},\n\tjournal = {The Israel Journal of Psychiatry and Related Sciences},\n\tauthor = {Lochner, Christine and Hemmings, Sian M. J. and Kinnear, Craig J. and Nel, Daan and Hemmings, Sian M. 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