Hoarding in obsessive-compulsive disorder: clinical and genetic correlates. Lochner, C., Kinnear, C. J., Hemmings, S. M. J., Seller, C., Niehaus, D. J. H., Knowles, J. A., Daniels, W., Moolman-Smook, J. C., Seedat, S., & Stein, D. J. The Journal of Clinical Psychiatry, 66(9):1155–1160, September, 2005. 00108
abstract   bibtex   
OBJECTIVE: Hoarding may be an important symptom dimension in obsessive-compulsive disorder (OCD). Hoarding in OCD has been associated with poor insight, poorer response to selective serotonin reuptake inhibitors than other OCD symptom dimensions, and a distinctive psychobiological profile. The clinical and genetic correlates of hoarding in OCD therefore deserve additional investigation. METHOD: Adult OCD patients (N = 315) underwent a comprehensive clinical assessment that included the Structured Clinical Interview for DSM-IV Axis I Disorders (Patient Edition) and for Diagnosis of Obsessive-Compulsive Spectrum Disorders. DNA extracted from venous blood (10-30 mL) in a Caucasian subset of the interviewed OCD patients (N = 204) and Caucasian controls (N = 169), including patients (N = 94) and controls (N = 138) of Afrikaner descent, was genotyped to investigate polymorphisms in genes involved in monoamine function and previously hypothesized to be relevant to OCD. Data were collected from 1998 through 2004. RESULTS: OCD patients with hoarding made up 18.1% of the total sample. Compared with nonhoarding OCD, OCD with hoarding was associated with a number of comorbid Axis I disorders, obsessive-compulsive personality disorder, significantly higher OCD severity scores, and more functional impairment. In subjects of Afrikaner descent, the L/L genotype of the COMT Val158Met polymorphism was significantly more common in the OCD hoarding group, with a preponderance of low activity alleles, compared with nonhoarding patients and controls. CONCLUSIONS: These data are consistent with the hypothesis that hoarding represents a unique symptom subtype in OCD with a distinctive clinical and psychobiological profile. Further work is needed to determine the psychobiological mechanisms responsible for hoarding and to replicate the genetic findings noted here.
@article{lochner_hoarding_2005,
	title = {Hoarding in obsessive-compulsive disorder: clinical and genetic correlates},
	volume = {66},
	issn = {0160-6689},
	shorttitle = {Hoarding in obsessive-compulsive disorder},
	abstract = {OBJECTIVE: Hoarding may be an important symptom dimension in obsessive-compulsive disorder (OCD). Hoarding in OCD has been associated with poor insight, poorer response to selective serotonin reuptake inhibitors than other OCD symptom dimensions, and a distinctive psychobiological profile. The clinical and genetic correlates of hoarding in OCD therefore deserve additional investigation.
METHOD: Adult OCD patients (N = 315) underwent a comprehensive clinical assessment that included the Structured Clinical Interview for DSM-IV Axis I Disorders (Patient Edition) and for Diagnosis of Obsessive-Compulsive Spectrum Disorders. DNA extracted from venous blood (10-30 mL) in a Caucasian subset of the interviewed OCD patients (N = 204) and Caucasian controls (N = 169), including patients (N = 94) and controls (N = 138) of Afrikaner descent, was genotyped to investigate polymorphisms in genes involved in monoamine function and previously hypothesized to be relevant to OCD. Data were collected from 1998 through 2004.
RESULTS: OCD patients with hoarding made up 18.1\% of the total sample. Compared with nonhoarding OCD, OCD with hoarding was associated with a number of comorbid Axis I disorders, obsessive-compulsive personality disorder, significantly higher OCD severity scores, and more functional impairment. In subjects of Afrikaner descent, the L/L genotype of the COMT Val158Met polymorphism was significantly more common in the OCD hoarding group, with a preponderance of low activity alleles, compared with nonhoarding patients and controls.
CONCLUSIONS: These data are consistent with the hypothesis that hoarding represents a unique symptom subtype in OCD with a distinctive clinical and psychobiological profile. Further work is needed to determine the psychobiological mechanisms responsible for hoarding and to replicate the genetic findings noted here.},
	language = {eng},
	number = {9},
	journal = {The Journal of Clinical Psychiatry},
	author = {Lochner, Christine and Kinnear, Craig J. and Hemmings, Sian M. J. and Seller, Cathlene and Niehaus, Dana J. H. and Knowles, James A. and Daniels, Willie and Moolman-Smook, Johanna C. and Seedat, Soraya and Stein, Dan J.},
	month = sep,
	year = {2005},
	pmid = {16187774},
	note = {00108 },
	keywords = {Adult, Catechol O-Methyltransferase, Child, Child Abuse, Comorbidity, Diagnostic and Statistical Manual of Mental Disorders, Disability Evaluation, Ethnic Groups, European Continental Ancestry Group, Female, Genotype, Humans, Male, Mental Disorders, Obsessive-Compulsive Disorder, Personality Inventory, Polymorphism, Genetic, Psychiatric Status Rating Scales, Severity of Illness Index, South Africa},
	pages = {1155--1160},
}

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