Hoarding in obsessive-compulsive disorder: clinical and genetic correlates. Lochner, C., Kinnear, C. J., Hemmings, S. M. J., Seller, C., Niehaus, D. J. H., Knowles, J. A., Daniels, W., Moolman-Smook, J. C., Seedat, S., & Stein, D. J. The Journal of Clinical Psychiatry, 66(9):1155–1160, September, 2005. 00108 abstract bibtex OBJECTIVE: Hoarding may be an important symptom dimension in obsessive-compulsive disorder (OCD). Hoarding in OCD has been associated with poor insight, poorer response to selective serotonin reuptake inhibitors than other OCD symptom dimensions, and a distinctive psychobiological profile. The clinical and genetic correlates of hoarding in OCD therefore deserve additional investigation. METHOD: Adult OCD patients (N = 315) underwent a comprehensive clinical assessment that included the Structured Clinical Interview for DSM-IV Axis I Disorders (Patient Edition) and for Diagnosis of Obsessive-Compulsive Spectrum Disorders. DNA extracted from venous blood (10-30 mL) in a Caucasian subset of the interviewed OCD patients (N = 204) and Caucasian controls (N = 169), including patients (N = 94) and controls (N = 138) of Afrikaner descent, was genotyped to investigate polymorphisms in genes involved in monoamine function and previously hypothesized to be relevant to OCD. Data were collected from 1998 through 2004. RESULTS: OCD patients with hoarding made up 18.1% of the total sample. Compared with nonhoarding OCD, OCD with hoarding was associated with a number of comorbid Axis I disorders, obsessive-compulsive personality disorder, significantly higher OCD severity scores, and more functional impairment. In subjects of Afrikaner descent, the L/L genotype of the COMT Val158Met polymorphism was significantly more common in the OCD hoarding group, with a preponderance of low activity alleles, compared with nonhoarding patients and controls. CONCLUSIONS: These data are consistent with the hypothesis that hoarding represents a unique symptom subtype in OCD with a distinctive clinical and psychobiological profile. Further work is needed to determine the psychobiological mechanisms responsible for hoarding and to replicate the genetic findings noted here.
@article{lochner_hoarding_2005,
title = {Hoarding in obsessive-compulsive disorder: clinical and genetic correlates},
volume = {66},
issn = {0160-6689},
shorttitle = {Hoarding in obsessive-compulsive disorder},
abstract = {OBJECTIVE: Hoarding may be an important symptom dimension in obsessive-compulsive disorder (OCD). Hoarding in OCD has been associated with poor insight, poorer response to selective serotonin reuptake inhibitors than other OCD symptom dimensions, and a distinctive psychobiological profile. The clinical and genetic correlates of hoarding in OCD therefore deserve additional investigation.
METHOD: Adult OCD patients (N = 315) underwent a comprehensive clinical assessment that included the Structured Clinical Interview for DSM-IV Axis I Disorders (Patient Edition) and for Diagnosis of Obsessive-Compulsive Spectrum Disorders. DNA extracted from venous blood (10-30 mL) in a Caucasian subset of the interviewed OCD patients (N = 204) and Caucasian controls (N = 169), including patients (N = 94) and controls (N = 138) of Afrikaner descent, was genotyped to investigate polymorphisms in genes involved in monoamine function and previously hypothesized to be relevant to OCD. Data were collected from 1998 through 2004.
RESULTS: OCD patients with hoarding made up 18.1\% of the total sample. Compared with nonhoarding OCD, OCD with hoarding was associated with a number of comorbid Axis I disorders, obsessive-compulsive personality disorder, significantly higher OCD severity scores, and more functional impairment. In subjects of Afrikaner descent, the L/L genotype of the COMT Val158Met polymorphism was significantly more common in the OCD hoarding group, with a preponderance of low activity alleles, compared with nonhoarding patients and controls.
CONCLUSIONS: These data are consistent with the hypothesis that hoarding represents a unique symptom subtype in OCD with a distinctive clinical and psychobiological profile. Further work is needed to determine the psychobiological mechanisms responsible for hoarding and to replicate the genetic findings noted here.},
language = {eng},
number = {9},
journal = {The Journal of Clinical Psychiatry},
author = {Lochner, Christine and Kinnear, Craig J. and Hemmings, Sian M. J. and Seller, Cathlene and Niehaus, Dana J. H. and Knowles, James A. and Daniels, Willie and Moolman-Smook, Johanna C. and Seedat, Soraya and Stein, Dan J.},
month = sep,
year = {2005},
pmid = {16187774},
note = {00108 },
keywords = {Adult, Catechol O-Methyltransferase, Child, Child Abuse, Comorbidity, Diagnostic and Statistical Manual of Mental Disorders, Disability Evaluation, Ethnic Groups, European Continental Ancestry Group, Female, Genotype, Humans, Male, Mental Disorders, Obsessive-Compulsive Disorder, Personality Inventory, Polymorphism, Genetic, Psychiatric Status Rating Scales, Severity of Illness Index, South Africa},
pages = {1155--1160},
}
Downloads: 0
{"_id":"FfpCTgaXMSdEbwffQ","bibbaseid":"lochner-kinnear-hemmings-seller-niehaus-knowles-daniels-moolmansmook-etal-hoardinginobsessivecompulsivedisorderclinicalandgeneticcorrelates-2005","author_short":["Lochner, C.","Kinnear, C. J.","Hemmings, S. M. J.","Seller, C.","Niehaus, D. J. H.","Knowles, J. A.","Daniels, W.","Moolman-Smook, J. C.","Seedat, S.","Stein, D. J."],"bibdata":{"bibtype":"article","type":"article","title":"Hoarding in obsessive-compulsive disorder: clinical and genetic correlates","volume":"66","issn":"0160-6689","shorttitle":"Hoarding in obsessive-compulsive disorder","abstract":"OBJECTIVE: Hoarding may be an important symptom dimension in obsessive-compulsive disorder (OCD). Hoarding in OCD has been associated with poor insight, poorer response to selective serotonin reuptake inhibitors than other OCD symptom dimensions, and a distinctive psychobiological profile. The clinical and genetic correlates of hoarding in OCD therefore deserve additional investigation. METHOD: Adult OCD patients (N = 315) underwent a comprehensive clinical assessment that included the Structured Clinical Interview for DSM-IV Axis I Disorders (Patient Edition) and for Diagnosis of Obsessive-Compulsive Spectrum Disorders. DNA extracted from venous blood (10-30 mL) in a Caucasian subset of the interviewed OCD patients (N = 204) and Caucasian controls (N = 169), including patients (N = 94) and controls (N = 138) of Afrikaner descent, was genotyped to investigate polymorphisms in genes involved in monoamine function and previously hypothesized to be relevant to OCD. Data were collected from 1998 through 2004. RESULTS: OCD patients with hoarding made up 18.1% of the total sample. Compared with nonhoarding OCD, OCD with hoarding was associated with a number of comorbid Axis I disorders, obsessive-compulsive personality disorder, significantly higher OCD severity scores, and more functional impairment. In subjects of Afrikaner descent, the L/L genotype of the COMT Val158Met polymorphism was significantly more common in the OCD hoarding group, with a preponderance of low activity alleles, compared with nonhoarding patients and controls. CONCLUSIONS: These data are consistent with the hypothesis that hoarding represents a unique symptom subtype in OCD with a distinctive clinical and psychobiological profile. Further work is needed to determine the psychobiological mechanisms responsible for hoarding and to replicate the genetic findings noted here.","language":"eng","number":"9","journal":"The Journal of Clinical Psychiatry","author":[{"propositions":[],"lastnames":["Lochner"],"firstnames":["Christine"],"suffixes":[]},{"propositions":[],"lastnames":["Kinnear"],"firstnames":["Craig","J."],"suffixes":[]},{"propositions":[],"lastnames":["Hemmings"],"firstnames":["Sian","M.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Seller"],"firstnames":["Cathlene"],"suffixes":[]},{"propositions":[],"lastnames":["Niehaus"],"firstnames":["Dana","J.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Knowles"],"firstnames":["James","A."],"suffixes":[]},{"propositions":[],"lastnames":["Daniels"],"firstnames":["Willie"],"suffixes":[]},{"propositions":[],"lastnames":["Moolman-Smook"],"firstnames":["Johanna","C."],"suffixes":[]},{"propositions":[],"lastnames":["Seedat"],"firstnames":["Soraya"],"suffixes":[]},{"propositions":[],"lastnames":["Stein"],"firstnames":["Dan","J."],"suffixes":[]}],"month":"September","year":"2005","pmid":"16187774","note":"00108 ","keywords":"Adult, Catechol O-Methyltransferase, Child, Child Abuse, Comorbidity, Diagnostic and Statistical Manual of Mental Disorders, Disability Evaluation, Ethnic Groups, European Continental Ancestry Group, Female, Genotype, Humans, Male, Mental Disorders, Obsessive-Compulsive Disorder, Personality Inventory, Polymorphism, Genetic, Psychiatric Status Rating Scales, Severity of Illness Index, South Africa","pages":"1155–1160","bibtex":"@article{lochner_hoarding_2005,\n\ttitle = {Hoarding in obsessive-compulsive disorder: clinical and genetic correlates},\n\tvolume = {66},\n\tissn = {0160-6689},\n\tshorttitle = {Hoarding in obsessive-compulsive disorder},\n\tabstract = {OBJECTIVE: Hoarding may be an important symptom dimension in obsessive-compulsive disorder (OCD). Hoarding in OCD has been associated with poor insight, poorer response to selective serotonin reuptake inhibitors than other OCD symptom dimensions, and a distinctive psychobiological profile. The clinical and genetic correlates of hoarding in OCD therefore deserve additional investigation.\nMETHOD: Adult OCD patients (N = 315) underwent a comprehensive clinical assessment that included the Structured Clinical Interview for DSM-IV Axis I Disorders (Patient Edition) and for Diagnosis of Obsessive-Compulsive Spectrum Disorders. DNA extracted from venous blood (10-30 mL) in a Caucasian subset of the interviewed OCD patients (N = 204) and Caucasian controls (N = 169), including patients (N = 94) and controls (N = 138) of Afrikaner descent, was genotyped to investigate polymorphisms in genes involved in monoamine function and previously hypothesized to be relevant to OCD. Data were collected from 1998 through 2004.\nRESULTS: OCD patients with hoarding made up 18.1\\% of the total sample. Compared with nonhoarding OCD, OCD with hoarding was associated with a number of comorbid Axis I disorders, obsessive-compulsive personality disorder, significantly higher OCD severity scores, and more functional impairment. In subjects of Afrikaner descent, the L/L genotype of the COMT Val158Met polymorphism was significantly more common in the OCD hoarding group, with a preponderance of low activity alleles, compared with nonhoarding patients and controls.\nCONCLUSIONS: These data are consistent with the hypothesis that hoarding represents a unique symptom subtype in OCD with a distinctive clinical and psychobiological profile. Further work is needed to determine the psychobiological mechanisms responsible for hoarding and to replicate the genetic findings noted here.},\n\tlanguage = {eng},\n\tnumber = {9},\n\tjournal = {The Journal of Clinical Psychiatry},\n\tauthor = {Lochner, Christine and Kinnear, Craig J. and Hemmings, Sian M. J. and Seller, Cathlene and Niehaus, Dana J. H. and Knowles, James A. and Daniels, Willie and Moolman-Smook, Johanna C. and Seedat, Soraya and Stein, Dan J.},\n\tmonth = sep,\n\tyear = {2005},\n\tpmid = {16187774},\n\tnote = {00108 },\n\tkeywords = {Adult, Catechol O-Methyltransferase, Child, Child Abuse, Comorbidity, Diagnostic and Statistical Manual of Mental Disorders, Disability Evaluation, Ethnic Groups, European Continental Ancestry Group, Female, Genotype, Humans, Male, Mental Disorders, Obsessive-Compulsive Disorder, Personality Inventory, Polymorphism, Genetic, Psychiatric Status Rating Scales, Severity of Illness Index, South Africa},\n\tpages = {1155--1160},\n}\n\n\n\n","author_short":["Lochner, C.","Kinnear, C. J.","Hemmings, S. M. J.","Seller, C.","Niehaus, D. J. H.","Knowles, J. A.","Daniels, W.","Moolman-Smook, J. C.","Seedat, S.","Stein, D. J."],"key":"lochner_hoarding_2005","id":"lochner_hoarding_2005","bibbaseid":"lochner-kinnear-hemmings-seller-niehaus-knowles-daniels-moolmansmook-etal-hoardinginobsessivecompulsivedisorderclinicalandgeneticcorrelates-2005","role":"author","urls":{},"keyword":["Adult","Catechol O-Methyltransferase","Child","Child Abuse","Comorbidity","Diagnostic and Statistical Manual of Mental Disorders","Disability Evaluation","Ethnic Groups","European Continental Ancestry Group","Female","Genotype","Humans","Male","Mental Disorders","Obsessive-Compulsive Disorder","Personality Inventory","Polymorphism","Genetic","Psychiatric Status Rating Scales","Severity of Illness Index","South Africa"],"metadata":{"authorlinks":{}},"downloads":0,"html":""},"bibtype":"article","biburl":"http://bibbase.org/zotero/TBHostGen","dataSources":["csPxbBZ9RG8CqYnrf"],"keywords":["adult","catechol o-methyltransferase","child","child abuse","comorbidity","diagnostic and statistical manual of mental disorders","disability evaluation","ethnic groups","european continental ancestry group","female","genotype","humans","male","mental disorders","obsessive-compulsive disorder","personality inventory","polymorphism","genetic","psychiatric status rating scales","severity of illness index","south africa"],"search_terms":["hoarding","obsessive","compulsive","disorder","clinical","genetic","correlates","lochner","kinnear","hemmings","seller","niehaus","knowles","daniels","moolman-smook","seedat","stein"],"title":"Hoarding in obsessive-compulsive disorder: clinical and genetic correlates","year":2005}