@article{locke_association_2024,
	title = {The association of weight loss from anti‐obesity medications or bariatric surgery and apnea‐hypopnea index in obstructive sleep apnea},
	volume = {25},
	issn = {1467-7881, 1467-789X},
	url = {https://onlinelibrary.wiley.com/doi/10.1111/obr.13697},
	doi = {10.1111/obr.13697},
	abstract = {Summary
            
              Introduction
              Weight loss is recommended for individuals with obstructive sleep apnea (OSA) and overweight or obesity, but there is limited evidence to guide the selection of weight management strategies for patients who do not lose sufficient weight with diet and lifestyle changes. We evaluated the relationship between weight loss caused by pharmacologic or surgical interventions and subsequent improvement in OSA by the apnea‐hypopnea index (AHI).
            
            
              Methods
              PubMed, Cochrane CENTRAL, and EMBASE were searched for randomized trials comparing pharmacologic or surgical obesity interventions to usual care, placebo, or no treatment in adults with OSA. The association between percentage weight loss and AHI change between randomization and last follow‐up was evaluated using meta‐regression. PROSPERO: CRD42022378853.
            
            
              Results
              
                Ten eligible trials (
                n
                 = 854 patients) were included. Four (
                n
                 = 211) assessed bariatric surgery, and 6 (
                n
                 = 643) assessed pharmacologic interventions over a median follow‐up of 13 months (interquartile range 6–26 months). The linear best estimate of the change in AHI is 0.45 events per hour (95\% Confidence Interval 0.18 to 0.73 events per hour) for every 1\% body weight lost.
              
            
            
              Conclusions
              Weight loss caused by medication or surgery caused a proportionate improvement of the AHI. Providers could consider extrapolating from this relationship when advising patients of the expected effects of other pharmacologic or surgical interventions without direct evidence in OSA.},
	language = {en},
	number = {4},
	urldate = {2024-12-13},
	journal = {Obesity Reviews},
	author = {Locke, Brian W. and Gomez‐Lumbreras, Ainhoa and Tan, Chia Jie and Nonthasawadsri, Teerawat and Veettil, Sajesh K. and Patikorn, Chanthawat and Chaiyakunapruk, Nathorn},
	month = apr,
	year = {2024},
	pages = {e13697},
}

{"_id":"muXh7RQkGm3kwSxMW","bibbaseid":"locke-gomezlumbreras-tan-nonthasawadsri-veettil-patikorn-chaiyakunapruk-theassociationofweightlossfromantiobesitymedicationsorbariatricsurgeryandapneahypopneaindexinobstructivesleepapnea-2024","author_short":["Locke, B. W.","Gomez‐Lumbreras, A.","Tan, C. J.","Nonthasawadsri, T.","Veettil, S. K.","Patikorn, C.","Chaiyakunapruk, N."],"bibdata":{"bibtype":"article","type":"article","title":"The association of weight loss from anti‐obesity medications or bariatric surgery and apnea‐hypopnea index in obstructive sleep apnea","volume":"25","issn":"1467-7881, 1467-789X","url":"https://onlinelibrary.wiley.com/doi/10.1111/obr.13697","doi":"10.1111/obr.13697","abstract":"Summary Introduction Weight loss is recommended for individuals with obstructive sleep apnea (OSA) and overweight or obesity, but there is limited evidence to guide the selection of weight management strategies for patients who do not lose sufficient weight with diet and lifestyle changes. We evaluated the relationship between weight loss caused by pharmacologic or surgical interventions and subsequent improvement in OSA by the apnea‐hypopnea index (AHI). Methods PubMed, Cochrane CENTRAL, and EMBASE were searched for randomized trials comparing pharmacologic or surgical obesity interventions to usual care, placebo, or no treatment in adults with OSA. The association between percentage weight loss and AHI change between randomization and last follow‐up was evaluated using meta‐regression. PROSPERO: CRD42022378853. Results Ten eligible trials ( n  = 854 patients) were included. Four ( n  = 211) assessed bariatric surgery, and 6 ( n  = 643) assessed pharmacologic interventions over a median follow‐up of 13 months (interquartile range 6–26 months). The linear best estimate of the change in AHI is 0.45 events per hour (95% Confidence Interval 0.18 to 0.73 events per hour) for every 1% body weight lost. Conclusions Weight loss caused by medication or surgery caused a proportionate improvement of the AHI. Providers could consider extrapolating from this relationship when advising patients of the expected effects of other pharmacologic or surgical interventions without direct evidence in OSA.","language":"en","number":"4","urldate":"2024-12-13","journal":"Obesity Reviews","author":[{"propositions":[],"lastnames":["Locke"],"firstnames":["Brian","W."],"suffixes":[]},{"propositions":[],"lastnames":["Gomez‐Lumbreras"],"firstnames":["Ainhoa"],"suffixes":[]},{"propositions":[],"lastnames":["Tan"],"firstnames":["Chia","Jie"],"suffixes":[]},{"propositions":[],"lastnames":["Nonthasawadsri"],"firstnames":["Teerawat"],"suffixes":[]},{"propositions":[],"lastnames":["Veettil"],"firstnames":["Sajesh","K."],"suffixes":[]},{"propositions":[],"lastnames":["Patikorn"],"firstnames":["Chanthawat"],"suffixes":[]},{"propositions":[],"lastnames":["Chaiyakunapruk"],"firstnames":["Nathorn"],"suffixes":[]}],"month":"April","year":"2024","pages":"e13697","bibtex":"@article{locke_association_2024,\n\ttitle = {The association of weight loss from anti‐obesity medications or bariatric surgery and apnea‐hypopnea index in obstructive sleep apnea},\n\tvolume = {25},\n\tissn = {1467-7881, 1467-789X},\n\turl = {https://onlinelibrary.wiley.com/doi/10.1111/obr.13697},\n\tdoi = {10.1111/obr.13697},\n\tabstract = {Summary\n \n Introduction\n Weight loss is recommended for individuals with obstructive sleep apnea (OSA) and overweight or obesity, but there is limited evidence to guide the selection of weight management strategies for patients who do not lose sufficient weight with diet and lifestyle changes. We evaluated the relationship between weight loss caused by pharmacologic or surgical interventions and subsequent improvement in OSA by the apnea‐hypopnea index (AHI).\n \n \n Methods\n PubMed, Cochrane CENTRAL, and EMBASE were searched for randomized trials comparing pharmacologic or surgical obesity interventions to usual care, placebo, or no treatment in adults with OSA. The association between percentage weight loss and AHI change between randomization and last follow‐up was evaluated using meta‐regression. PROSPERO: CRD42022378853.\n \n \n Results\n \n Ten eligible trials (\n n\n  = 854 patients) were included. Four (\n n\n  = 211) assessed bariatric surgery, and 6 (\n n\n  = 643) assessed pharmacologic interventions over a median follow‐up of 13 months (interquartile range 6–26 months). The linear best estimate of the change in AHI is 0.45 events per hour (95\\% Confidence Interval 0.18 to 0.73 events per hour) for every 1\\% body weight lost.\n \n \n \n Conclusions\n Weight loss caused by medication or surgery caused a proportionate improvement of the AHI. Providers could consider extrapolating from this relationship when advising patients of the expected effects of other pharmacologic or surgical interventions without direct evidence in OSA.},\n\tlanguage = {en},\n\tnumber = {4},\n\turldate = {2024-12-13},\n\tjournal = {Obesity Reviews},\n\tauthor = {Locke, Brian W. and Gomez‐Lumbreras, Ainhoa and Tan, Chia Jie and Nonthasawadsri, Teerawat and Veettil, Sajesh K. and Patikorn, Chanthawat and Chaiyakunapruk, Nathorn},\n\tmonth = apr,\n\tyear = {2024},\n\tpages = {e13697},\n}\n\n","author_short":["Locke, B. W.","Gomez‐Lumbreras, A.","Tan, C. J.","Nonthasawadsri, T.","Veettil, S. K.","Patikorn, C.","Chaiyakunapruk, N."],"key":"locke_association_2024","id":"locke_association_2024","bibbaseid":"locke-gomezlumbreras-tan-nonthasawadsri-veettil-patikorn-chaiyakunapruk-theassociationofweightlossfromantiobesitymedicationsorbariatricsurgeryandapneahypopneaindexinobstructivesleepapnea-2024","role":"author","urls":{"Paper":"https://onlinelibrary.wiley.com/doi/10.1111/obr.13697"},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://api.zotero.org/users/1528358/collections/DH4R6ZWA/items?key=L8lztpUgybScRoWSW76OhIE0&format=bibtex&limit=100","dataSources":["hoqThwEepw4WmWudJ"],"keywords":[],"search_terms":["association","weight","loss","anti","obesity","medications","bariatric","surgery","apnea","hypopnea","index","obstructive","sleep","apnea","locke","gomez‐lumbreras","tan","nonthasawadsri","veettil","patikorn","chaiyakunapruk"],"title":"The association of weight loss from anti‐obesity medications or bariatric surgery and apnea‐hypopnea index in obstructive sleep apnea","year":2024}