@article{Loiseau2020,
abstract = {We analysed 312 drug-resistant genomes of Mycobacterium tuberculosis (Mtb ) collected from HIV coinfected and HIV negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant Mtb strains isolated from HIV coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of the drug, suggesting these low fitness rpoB variants can thrive in the context of reduced host immunity.},
author = {Loiseau, Chlo{\'{e}} and Brites, Daniela and Reinhard, Miriam and Z{\"{u}}rcher, Kathrin and Borrell, Sonia and Ballif, Marie and Fenner, Lukas and Cox, Helen and Rutaihwa, Liliana K and Wilkinson, Robert J and Yotebieng, Marcel and Carter, E Jane and Abimiku, Alash'le and Marcy, Olivier and Gotuzzo, Eduardo and Avihingsanon, Anchalee and Zetola, Nicola and Doulla, Basra and B{\"{o}}ttger, Erik C and Egger, Matthias and Gagneux, Sebastien},
doi = {10.1128/AAC.00782-20},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Loiseau et al. - 2020 - HIV coinfection is associated with low fitness rpoB variants in rifampicin-resistant Mycobacterium tuberculosis.pdf:pdf},
issn = {0066-4804},
journal = {Antimicrobial Agents and Chemotherapy},
keywords = {OA,fund{\_}ack,original},
mendeley-tags = {OA,fund{\_}ack,original},
month = {jul},
number = {10},
pages = {e00782},
pmid = {32718966},
publisher = {American Society for Microbiology Journals},
title = {{HIV coinfection is associated with low fitness rpoB variants in rifampicin-resistant Mycobacterium tuberculosis}},
url = {http://aac.asm.org/lookup/doi/10.1128/AAC.00782-20},
volume = {64},
year = {2020}
}

{"_id":"RuPxt5nbDmMRSQC2K","bibbaseid":"loiseau-brites-reinhard-zrcher-borrell-ballif-fenner-cox-etal-hivcoinfectionisassociatedwithlowfitnessrpobvariantsinrifampicinresistantmycobacteriumtuberculosis-2020","authorIDs":[],"author_short":["Loiseau, C.","Brites, D.","Reinhard, M.","Zürcher, K.","Borrell, S.","Ballif, M.","Fenner, L.","Cox, H.","Rutaihwa, L. K","Wilkinson, R. J","Yotebieng, M.","Carter, E J.","Abimiku, A.","Marcy, O.","Gotuzzo, E.","Avihingsanon, A.","Zetola, N.","Doulla, B.","Böttger, E. C","Egger, M.","Gagneux, S."],"bibdata":{"bibtype":"article","type":"article","abstract":"We analysed 312 drug-resistant genomes of Mycobacterium tuberculosis (Mtb ) collected from HIV coinfected and HIV negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant Mtb strains isolated from HIV coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of the drug, suggesting these low fitness rpoB variants can thrive in the context of reduced host immunity.","author":[{"propositions":[],"lastnames":["Loiseau"],"firstnames":["Chloé"],"suffixes":[]},{"propositions":[],"lastnames":["Brites"],"firstnames":["Daniela"],"suffixes":[]},{"propositions":[],"lastnames":["Reinhard"],"firstnames":["Miriam"],"suffixes":[]},{"propositions":[],"lastnames":["Zürcher"],"firstnames":["Kathrin"],"suffixes":[]},{"propositions":[],"lastnames":["Borrell"],"firstnames":["Sonia"],"suffixes":[]},{"propositions":[],"lastnames":["Ballif"],"firstnames":["Marie"],"suffixes":[]},{"propositions":[],"lastnames":["Fenner"],"firstnames":["Lukas"],"suffixes":[]},{"propositions":[],"lastnames":["Cox"],"firstnames":["Helen"],"suffixes":[]},{"propositions":[],"lastnames":["Rutaihwa"],"firstnames":["Liliana","K"],"suffixes":[]},{"propositions":[],"lastnames":["Wilkinson"],"firstnames":["Robert","J"],"suffixes":[]},{"propositions":[],"lastnames":["Yotebieng"],"firstnames":["Marcel"],"suffixes":[]},{"propositions":[],"lastnames":["Carter"],"firstnames":["E","Jane"],"suffixes":[]},{"propositions":[],"lastnames":["Abimiku"],"firstnames":["Alash'le"],"suffixes":[]},{"propositions":[],"lastnames":["Marcy"],"firstnames":["Olivier"],"suffixes":[]},{"propositions":[],"lastnames":["Gotuzzo"],"firstnames":["Eduardo"],"suffixes":[]},{"propositions":[],"lastnames":["Avihingsanon"],"firstnames":["Anchalee"],"suffixes":[]},{"propositions":[],"lastnames":["Zetola"],"firstnames":["Nicola"],"suffixes":[]},{"propositions":[],"lastnames":["Doulla"],"firstnames":["Basra"],"suffixes":[]},{"propositions":[],"lastnames":["Böttger"],"firstnames":["Erik","C"],"suffixes":[]},{"propositions":[],"lastnames":["Egger"],"firstnames":["Matthias"],"suffixes":[]},{"propositions":[],"lastnames":["Gagneux"],"firstnames":["Sebastien"],"suffixes":[]}],"doi":"10.1128/AAC.00782-20","file":":C$\\$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Loiseau et al. - 2020 - HIV coinfection is associated with low fitness rpoB variants in rifampicin-resistant Mycobacterium tuberculosis.pdf:pdf","issn":"0066-4804","journal":"Antimicrobial Agents and Chemotherapy","keywords":"OA,fund_ack,original","mendeley-tags":"OA,fund_ack,original","month":"jul","number":"10","pages":"e00782","pmid":"32718966","publisher":"American Society for Microbiology Journals","title":"HIV coinfection is associated with low fitness rpoB variants in rifampicin-resistant Mycobacterium tuberculosis","url":"http://aac.asm.org/lookup/doi/10.1128/AAC.00782-20","volume":"64","year":"2020","bibtex":"@article{Loiseau2020,\r\nabstract = {We analysed 312 drug-resistant genomes of Mycobacterium tuberculosis (Mtb ) collected from HIV coinfected and HIV negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant Mtb strains isolated from HIV coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of the drug, suggesting these low fitness rpoB variants can thrive in the context of reduced host immunity.},\r\nauthor = {Loiseau, Chlo{\\'{e}} and Brites, Daniela and Reinhard, Miriam and Z{\\\"{u}}rcher, Kathrin and Borrell, Sonia and Ballif, Marie and Fenner, Lukas and Cox, Helen and Rutaihwa, Liliana K and Wilkinson, Robert J and Yotebieng, Marcel and Carter, E Jane and Abimiku, Alash'le and Marcy, Olivier and Gotuzzo, Eduardo and Avihingsanon, Anchalee and Zetola, Nicola and Doulla, Basra and B{\\\"{o}}ttger, Erik C and Egger, Matthias and Gagneux, Sebastien},\r\ndoi = {10.1128/AAC.00782-20},\r\nfile = {:C$\\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Loiseau et al. - 2020 - HIV coinfection is associated with low fitness rpoB variants in rifampicin-resistant Mycobacterium tuberculosis.pdf:pdf},\r\nissn = {0066-4804},\r\njournal = {Antimicrobial Agents and Chemotherapy},\r\nkeywords = {OA,fund{\\_}ack,original},\r\nmendeley-tags = {OA,fund{\\_}ack,original},\r\nmonth = {jul},\r\nnumber = {10},\r\npages = {e00782},\r\npmid = {32718966},\r\npublisher = {American Society for Microbiology Journals},\r\ntitle = {{HIV coinfection is associated with low fitness rpoB variants in rifampicin-resistant Mycobacterium tuberculosis}},\r\nurl = {http://aac.asm.org/lookup/doi/10.1128/AAC.00782-20},\r\nvolume = {64},\r\nyear = {2020}\r\n}\r\n","author_short":["Loiseau, C.","Brites, D.","Reinhard, M.","Zürcher, K.","Borrell, S.","Ballif, M.","Fenner, L.","Cox, H.","Rutaihwa, L. K","Wilkinson, R. J","Yotebieng, M.","Carter, E J.","Abimiku, A.","Marcy, O.","Gotuzzo, E.","Avihingsanon, A.","Zetola, N.","Doulla, B.","Böttger, E. C","Egger, M.","Gagneux, S."],"key":"Loiseau2020","id":"Loiseau2020","bibbaseid":"loiseau-brites-reinhard-zrcher-borrell-ballif-fenner-cox-etal-hivcoinfectionisassociatedwithlowfitnessrpobvariantsinrifampicinresistantmycobacteriumtuberculosis-2020","role":"author","urls":{"Paper":"http://aac.asm.org/lookup/doi/10.1128/AAC.00782-20"},"keyword":["OA","fund_ack","original"],"metadata":{"authorlinks":{}},"downloads":0},"bibtype":"article","biburl":"https://drive.google.com/uc?export=download&id=1-JLqZ7RwZ3VC2d6ErLGHAtOeMRS_7GCz","creationDate":"2020-10-16T07:32:25.045Z","downloads":0,"keywords":["oa","fund_ack","original"],"search_terms":["hiv","coinfection","associated","low","fitness","rpob","variants","rifampicin","resistant","mycobacterium","tuberculosis","loiseau","brites","reinhard","zürcher","borrell","ballif","fenner","cox","rutaihwa","wilkinson","yotebieng","carter","abimiku","marcy","gotuzzo","avihingsanon","zetola","doulla","böttger","egger","gagneux"],"title":"HIV coinfection is associated with low fitness rpoB variants in rifampicin-resistant Mycobacterium tuberculosis","year":2020,"dataSources":["Krmt6gt9ktB2s6ARh","FdCBAxFeyKEmJd8WK","9bX4N36CTXtCXNFMd","wrEvssexmuYudwQw9"]}