@article{lorenzi_anti-srage_2014,
	title = {Anti-{sRAGE} autoimmunity in obesity: {Downturn} after bariatric surgery is independent of previous diabetic status},
	issn = {1878-1780},
	shorttitle = {Anti-{sRAGE} autoimmunity in obesity},
	doi = {10.1016/j.diabet.2014.04.008},
	abstract = {AIM: Morbid obesity increases the risk of cardiovascular disease (CVD). The receptor for advanced glycation end-products (RAGE) is implicated in proinflammatory processes that underlie CVD. Its soluble form (sRAGE) has been proposed as a vascular biomarker. Recently, anti-sRAGE autoantibodies were described and found to be increased in diseases where RAGE is overexpressed. This study aimed to investigate serum levels of anti-sRAGE autoantibodies in morbidly obese patients.
METHODS: After exclusion based on specific criteria, 150 subjects (50 normoglycemics, 50 glucose-intolerants and 50 diabetics) were randomly recruited from a cohort of 750 obese patients (ABOS). Serum sRAGE and anti-sRAGE autoantibodies were measured before bariatric surgery. Sixty-nine patients were followed for up to 1year after gastric bypass, and their levels of sRAGE and anti-sRAGE autoantibodies measured. The control group consisted of healthy blood donors.
RESULTS: Compared with controls, baseline levels of sRAGE and anti-sRAGE autoantibodies were significantly higher in all obese patients independently of glucose regulation (P{\textless}0.001). At 1year after gastric bypass, sRAGE and anti-sRAGE were decreased (P{\textless}0.001). The decrease in anti-sRAGE autoantibodies was correlated with an increase in high-density lipoprotein (HDL; P=0.02).
CONCLUSION: Independently of previous diabetic status, morbid obesity increases sRAGE and anti-sRAGE levels. Weight loss after gastric bypass is followed by a decrease in both titres. The decrease in anti-sRAGE correlates with an increase in HDL.},
	language = {ENG},
	journal = {Diabetes \& Metabolism},
	author = {Lorenzi, R. and Pattou, F. and Beuscart, J.-B. and Grossin, N. and Lambert, M. and Fontaine, P. and Caiazzo, R. and Pigeyre, M. and Patrice, A. and Daroux, M. and Boulanger, E. and Dubucquoi, S.},
	month = jun,
	year = {2014},
	pmid = {24933232},
}

{"_id":"drT5YdzFotnvGJfuB","bibbaseid":"lorenzi-pattou-beuscart-grossin-lambert-fontaine-caiazzo-pigeyre-etal-antisrageautoimmunityinobesitydownturnafterbariatricsurgeryisindependentofpreviousdiabeticstatus-2014","author_short":["Lorenzi, R.","Pattou, F.","Beuscart, J.","Grossin, N.","Lambert, M.","Fontaine, P.","Caiazzo, R.","Pigeyre, M.","Patrice, A.","Daroux, M.","Boulanger, E.","Dubucquoi, S."],"bibdata":{"bibtype":"article","type":"article","title":"Anti-sRAGE autoimmunity in obesity: Downturn after bariatric surgery is independent of previous diabetic status","issn":"1878-1780","shorttitle":"Anti-sRAGE autoimmunity in obesity","doi":"10.1016/j.diabet.2014.04.008","abstract":"AIM: Morbid obesity increases the risk of cardiovascular disease (CVD). The receptor for advanced glycation end-products (RAGE) is implicated in proinflammatory processes that underlie CVD. Its soluble form (sRAGE) has been proposed as a vascular biomarker. Recently, anti-sRAGE autoantibodies were described and found to be increased in diseases where RAGE is overexpressed. This study aimed to investigate serum levels of anti-sRAGE autoantibodies in morbidly obese patients. METHODS: After exclusion based on specific criteria, 150 subjects (50 normoglycemics, 50 glucose-intolerants and 50 diabetics) were randomly recruited from a cohort of 750 obese patients (ABOS). Serum sRAGE and anti-sRAGE autoantibodies were measured before bariatric surgery. Sixty-nine patients were followed for up to 1year after gastric bypass, and their levels of sRAGE and anti-sRAGE autoantibodies measured. The control group consisted of healthy blood donors. RESULTS: Compared with controls, baseline levels of sRAGE and anti-sRAGE autoantibodies were significantly higher in all obese patients independently of glucose regulation (P\\textless0.001). At 1year after gastric bypass, sRAGE and anti-sRAGE were decreased (P\\textless0.001). The decrease in anti-sRAGE autoantibodies was correlated with an increase in high-density lipoprotein (HDL; P=0.02). CONCLUSION: Independently of previous diabetic status, morbid obesity increases sRAGE and anti-sRAGE levels. Weight loss after gastric bypass is followed by a decrease in both titres. The decrease in anti-sRAGE correlates with an increase in HDL.","language":"ENG","journal":"Diabetes & Metabolism","author":[{"propositions":[],"lastnames":["Lorenzi"],"firstnames":["R."],"suffixes":[]},{"propositions":[],"lastnames":["Pattou"],"firstnames":["F."],"suffixes":[]},{"propositions":[],"lastnames":["Beuscart"],"firstnames":["J.-B."],"suffixes":[]},{"propositions":[],"lastnames":["Grossin"],"firstnames":["N."],"suffixes":[]},{"propositions":[],"lastnames":["Lambert"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Fontaine"],"firstnames":["P."],"suffixes":[]},{"propositions":[],"lastnames":["Caiazzo"],"firstnames":["R."],"suffixes":[]},{"propositions":[],"lastnames":["Pigeyre"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Patrice"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Daroux"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Boulanger"],"firstnames":["E."],"suffixes":[]},{"propositions":[],"lastnames":["Dubucquoi"],"firstnames":["S."],"suffixes":[]}],"month":"June","year":"2014","pmid":"24933232","bibtex":"@article{lorenzi_anti-srage_2014,\n\ttitle = {Anti-{sRAGE} autoimmunity in obesity: {Downturn} after bariatric surgery is independent of previous diabetic status},\n\tissn = {1878-1780},\n\tshorttitle = {Anti-{sRAGE} autoimmunity in obesity},\n\tdoi = {10.1016/j.diabet.2014.04.008},\n\tabstract = {AIM: Morbid obesity increases the risk of cardiovascular disease (CVD). The receptor for advanced glycation end-products (RAGE) is implicated in proinflammatory processes that underlie CVD. Its soluble form (sRAGE) has been proposed as a vascular biomarker. Recently, anti-sRAGE autoantibodies were described and found to be increased in diseases where RAGE is overexpressed. This study aimed to investigate serum levels of anti-sRAGE autoantibodies in morbidly obese patients.\nMETHODS: After exclusion based on specific criteria, 150 subjects (50 normoglycemics, 50 glucose-intolerants and 50 diabetics) were randomly recruited from a cohort of 750 obese patients (ABOS). Serum sRAGE and anti-sRAGE autoantibodies were measured before bariatric surgery. Sixty-nine patients were followed for up to 1year after gastric bypass, and their levels of sRAGE and anti-sRAGE autoantibodies measured. The control group consisted of healthy blood donors.\nRESULTS: Compared with controls, baseline levels of sRAGE and anti-sRAGE autoantibodies were significantly higher in all obese patients independently of glucose regulation (P{\\textless}0.001). At 1year after gastric bypass, sRAGE and anti-sRAGE were decreased (P{\\textless}0.001). The decrease in anti-sRAGE autoantibodies was correlated with an increase in high-density lipoprotein (HDL; P=0.02).\nCONCLUSION: Independently of previous diabetic status, morbid obesity increases sRAGE and anti-sRAGE levels. Weight loss after gastric bypass is followed by a decrease in both titres. The decrease in anti-sRAGE correlates with an increase in HDL.},\n\tlanguage = {ENG},\n\tjournal = {Diabetes \\& Metabolism},\n\tauthor = {Lorenzi, R. and Pattou, F. and Beuscart, J.-B. and Grossin, N. and Lambert, M. and Fontaine, P. and Caiazzo, R. and Pigeyre, M. and Patrice, A. and Daroux, M. and Boulanger, E. and Dubucquoi, S.},\n\tmonth = jun,\n\tyear = {2014},\n\tpmid = {24933232},\n}\n\n","author_short":["Lorenzi, R.","Pattou, F.","Beuscart, J.","Grossin, N.","Lambert, M.","Fontaine, P.","Caiazzo, R.","Pigeyre, M.","Patrice, A.","Daroux, M.","Boulanger, E.","Dubucquoi, S."],"key":"lorenzi_anti-srage_2014","id":"lorenzi_anti-srage_2014","bibbaseid":"lorenzi-pattou-beuscart-grossin-lambert-fontaine-caiazzo-pigeyre-etal-antisrageautoimmunityinobesitydownturnafterbariatricsurgeryisindependentofpreviousdiabeticstatus-2014","role":"author","urls":{},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://api.zotero.org/users/576834/collections/NYCBQQBB/items?key=MJNBdUsYThALl7viNVVbkecN&format=bibtex&limit=100","dataSources":["KcAAuaxski6XBszw2"],"keywords":[],"search_terms":["anti","srage","autoimmunity","obesity","downturn","bariatric","surgery","independent","previous","diabetic","status","lorenzi","pattou","beuscart","grossin","lambert","fontaine","caiazzo","pigeyre","patrice","daroux","boulanger","dubucquoi"],"title":"Anti-sRAGE autoimmunity in obesity: Downturn after bariatric surgery is independent of previous diabetic status","year":2014}