@ARTICLE{Lo_Turco1991-bz,
  title    = "Clusters of coupled neuroblasts in embryonic neocortex",
  author   = "Lo Turco, J J and Kriegstein, A R",
  abstract = "The neocortex of the brain develops from a simple germinal layer
              into a complex multilayer structure. To investigate cellular
              interactions during early neocortical development, whole-cell
              patch clamp recordings were made from neuroblasts in the
              ventricular zone of fetal rats. During early corticogenesis,
              neuroblasts are physiologically coupled by gap junctions into
              clusters of 15 to 90 cells. The coupled cells form columns within
              the ventricular zone and, by virtue of their membership in
              clusters, have low apparent membrane resistances and generate
              large responses to the inhibitory neurotransmitter
              gamma-aminobutyric acid. As neuronal migration out of the
              ventricular zone progresses, the number of cells within the
              clusters decreases. These clusters allow direct cell to cell
              interaction at the earliest stages of corticogenesis.",
  journal  = "Science",
  volume   =  252,
  number   =  5005,
  pages    = "563--566",
  month    =  apr,
  year     =  1991,
  address  = "United States",
  language = "en"
}

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