@ARTICLE{LoTurco1995-qf,
  title    = "{GABA} and glutamate depolarize cortical progenitor cells and
              inhibit {DNA} synthesis",
  author   = "LoTurco, J J and Owens, D F and Heath, M J and Davis, M B and
              Kriegstein, A R",
  abstract = "We have found that, during the early stages of cortical
              neurogenesis, both GABA and glutamate depolarize cells in the
              ventricular zone of rat embryonic neocortex. In the ventricular
              zone, glutamate acts on AMPA/kainate receptors, while GABA acts
              on GABAA receptors. GABA induces an inward current at resting
              membrane potentials, presumably owing to a high intracellular Cl-
              concentration maintained by furosemide-sensitive Cl- transport.
              GABA and glutamate also produce increases in intracellular Ca2+
              in ventricular zone cells, in part through activation of
              voltage-gated Ca2+ channels. Furthermore, GABA and glutamate
              decrease the number of embryonic cortical cells synthesizing DNA.
              Depolarization with K+ similarly decreases DNA synthesis,
              suggesting that the neurotransmitters act via membrane
              depolarization. Applied alone, GABAA and AMPA/kainate receptor
              antagonists increase DNA synthesis, indicating that endogenously
              released amino acids influence neocortical progenitors in the
              cell cycle. These results demonstrate a novel role for amino acid
              neurotransmitters in regulating neocortical neurogenesis.",
  journal  = "Neuron",
  volume   =  15,
  number   =  6,
  pages    = "1287--1298",
  month    =  dec,
  year     =  1995,
  address  = "United States",
  language = "en"
}

{"_id":"hbJczeaP65CvpD3fk","bibbaseid":"loturco-owens-heath-davis-kriegstein-gabaandglutamatedepolarizecorticalprogenitorcellsandinhibitdnasynthesis-1995","author_short":["LoTurco, J J","Owens, D F","Heath, M J","Davis, M B","Kriegstein, A R"],"bibdata":{"bibtype":"article","type":"article","title":"GABA and glutamate depolarize cortical progenitor cells and inhibit DNA synthesis","author":[{"propositions":[],"lastnames":["LoTurco"],"firstnames":["J","J"],"suffixes":[]},{"propositions":[],"lastnames":["Owens"],"firstnames":["D","F"],"suffixes":[]},{"propositions":[],"lastnames":["Heath"],"firstnames":["M","J"],"suffixes":[]},{"propositions":[],"lastnames":["Davis"],"firstnames":["M","B"],"suffixes":[]},{"propositions":[],"lastnames":["Kriegstein"],"firstnames":["A","R"],"suffixes":[]}],"abstract":"We have found that, during the early stages of cortical neurogenesis, both GABA and glutamate depolarize cells in the ventricular zone of rat embryonic neocortex. In the ventricular zone, glutamate acts on AMPA/kainate receptors, while GABA acts on GABAA receptors. GABA induces an inward current at resting membrane potentials, presumably owing to a high intracellular Cl- concentration maintained by furosemide-sensitive Cl- transport. GABA and glutamate also produce increases in intracellular Ca2+ in ventricular zone cells, in part through activation of voltage-gated Ca2+ channels. Furthermore, GABA and glutamate decrease the number of embryonic cortical cells synthesizing DNA. Depolarization with K+ similarly decreases DNA synthesis, suggesting that the neurotransmitters act via membrane depolarization. Applied alone, GABAA and AMPA/kainate receptor antagonists increase DNA synthesis, indicating that endogenously released amino acids influence neocortical progenitors in the cell cycle. These results demonstrate a novel role for amino acid neurotransmitters in regulating neocortical neurogenesis.","journal":"Neuron","volume":"15","number":"6","pages":"1287–1298","month":"December","year":"1995","address":"United States","language":"en","bibtex":"@ARTICLE{LoTurco1995-qf,\n title = \"{GABA} and glutamate depolarize cortical progenitor cells and\n inhibit {DNA} synthesis\",\n author = \"LoTurco, J J and Owens, D F and Heath, M J and Davis, M B and\n Kriegstein, A R\",\n abstract = \"We have found that, during the early stages of cortical\n neurogenesis, both GABA and glutamate depolarize cells in the\n ventricular zone of rat embryonic neocortex. In the ventricular\n zone, glutamate acts on AMPA/kainate receptors, while GABA acts\n on GABAA receptors. GABA induces an inward current at resting\n membrane potentials, presumably owing to a high intracellular Cl-\n concentration maintained by furosemide-sensitive Cl- transport.\n GABA and glutamate also produce increases in intracellular Ca2+\n in ventricular zone cells, in part through activation of\n voltage-gated Ca2+ channels. Furthermore, GABA and glutamate\n decrease the number of embryonic cortical cells synthesizing DNA.\n Depolarization with K+ similarly decreases DNA synthesis,\n suggesting that the neurotransmitters act via membrane\n depolarization. Applied alone, GABAA and AMPA/kainate receptor\n antagonists increase DNA synthesis, indicating that endogenously\n released amino acids influence neocortical progenitors in the\n cell cycle. These results demonstrate a novel role for amino acid\n neurotransmitters in regulating neocortical neurogenesis.\",\n journal = \"Neuron\",\n volume = 15,\n number = 6,\n pages = \"1287--1298\",\n month = dec,\n year = 1995,\n address = \"United States\",\n language = \"en\"\n}\n\n","author_short":["LoTurco, J J","Owens, D F","Heath, M J","Davis, M B","Kriegstein, A R"],"key":"LoTurco1995-qf","id":"LoTurco1995-qf","bibbaseid":"loturco-owens-heath-davis-kriegstein-gabaandglutamatedepolarizecorticalprogenitorcellsandinhibitdnasynthesis-1995","role":"author","urls":{},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/f/EJMp3HRuxirjxpcXh/references.bib","dataSources":["sAFYeB74DpbdXM9NN","4zx9n2tbeLTix3Wxr","k3cdWrThyTh5o59Rm","hq9pebjzmsTuyxGGx","h8Atv2SAy4PmShg5j"],"keywords":[],"search_terms":["gaba","glutamate","depolarize","cortical","progenitor","cells","inhibit","dna","synthesis","loturco","owens","heath","davis","kriegstein"],"title":"GABA and glutamate depolarize cortical progenitor cells and inhibit DNA synthesis","year":1995}