Porphysome nanovesicles generated by porphyrin bilayers for use as multimodal biophotonic contrast agents. Lovell, J. F., Jin, C. S., Huynh, E., Jin, H., Kim, C., Rubinstein, J. L., Chan, W. C. W., Cao, W., Wang, L. V., & Zheng, G. Nature Mater, 10(4):324–332, April, 2011. Bandiera_abtest: a Cg_type: Nature Research Journals Number: 4 Primary_atype: Research Publisher: Nature Publishing Group Subject_term: Biomedical materials;Imaging techniques;Nanoscale materials Subject_term_id: biomedical-materials;imaging-techniques;nanoscale-materials![Porphysome nanovesicles generated by porphyrin bilayers for use as multimodal biophotonic contrast agents [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Optically active nanomaterials promise to advance a range of biophotonic techniques through nanoscale optical effects and integration of multiple imaging and therapeutic modalities. Here, we report the development of porphysomes; nanovesicles formed from self-assembled porphyrin bilayers that generated large, tunable extinction coefficients, structure-dependent fluorescence self-quenching and unique photothermal and photoacoustic properties. Porphysomes enabled the sensitive visualization of lymphatic systems using photoacoustic tomography. Near-infrared fluorescence generation could be restored on dissociation, creating opportunities for low-background fluorescence imaging. As a result of their organic nature, porphysomes were enzymatically biodegradable and induced minimal acute toxicity in mice with intravenous doses of 1,000 mg kg−1. In a similar manner to liposomes, the large aqueous core of porphysomes could be passively or actively loaded. Following systemic administration, porphysomes accumulated in tumours of xenograft-bearing mice and laser irradiation induced photothermal tumour ablation. The optical properties and biocompatibility of porphysomes demonstrate the multimodal potential of organic nanoparticles for biophotonic imaging and therapy.
@article{lovell_porphysome_2011-1,
title = {Porphysome nanovesicles generated by porphyrin bilayers for use as multimodal biophotonic contrast agents},
volume = {10},
copyright = {2011 Nature Publishing Group},
issn = {1476-4660},
url = {https://www.nature.com/articles/nmat2986},
doi = {10.1038/nmat2986},
abstract = {Optically active nanomaterials promise to advance a range of biophotonic techniques through nanoscale optical effects and integration of multiple imaging and therapeutic modalities. Here, we report the development of porphysomes; nanovesicles formed from self-assembled porphyrin bilayers that generated large, tunable extinction coefficients, structure-dependent fluorescence self-quenching and unique photothermal and photoacoustic properties. Porphysomes enabled the sensitive visualization of lymphatic systems using photoacoustic tomography. Near-infrared fluorescence generation could be restored on dissociation, creating opportunities for low-background fluorescence imaging. As a result of their organic nature, porphysomes were enzymatically biodegradable and induced minimal acute toxicity in mice with intravenous doses of 1,000 mg kg−1. In a similar manner to liposomes, the large aqueous core of porphysomes could be passively or actively loaded. Following systemic administration, porphysomes accumulated in tumours of xenograft-bearing mice and laser irradiation induced photothermal tumour ablation. The optical properties and biocompatibility of porphysomes demonstrate the multimodal potential of organic nanoparticles for biophotonic imaging and therapy.},
language = {en},
number = {4},
urldate = {2021-11-06},
journal = {Nature Mater},
author = {Lovell, Jonathan F. and Jin, Cheng S. and Huynh, Elizabeth and Jin, Honglin and Kim, Chulhong and Rubinstein, John L. and Chan, Warren C. W. and Cao, Weiguo and Wang, Lihong V. and Zheng, Gang},
month = apr,
year = {2011},
note = {Bandiera\_abtest: a
Cg\_type: Nature Research Journals
Number: 4
Primary\_atype: Research
Publisher: Nature Publishing Group
Subject\_term: Biomedical materials;Imaging techniques;Nanoscale materials
Subject\_term\_id: biomedical-materials;imaging-techniques;nanoscale-materials},
keywords = {Biomedical materials, Imaging techniques, Nanoscale materials},
pages = {324--332},
file = {Full Text PDF:files/2148/Lovell et al. - 2011 - Porphysome nanovesicles generated by porphyrin bil.pdf:application/pdf;Snapshot:files/2149/nmat2986.html:text/html},
}
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