Cancer Cell Lysate Entrapment in CaCO3 Engineered with Polymeric TLR-Agonists: Immune-Modulating Microparticles in View of Personalized Antitumor Vaccination. Lybaert, L., Ryu, K. A., Nuhn, L., De Rycke, R., De Wever, O., Chon, A. C., Esser-Kahn, A. P., & De Geest, B. G. Chemistry of Materials, 29(10):4209--4217, May, 2017. ![Cancer Cell Lysate Entrapment in CaCO3 Engineered with Polymeric TLR-Agonists: Immune-Modulating Microparticles in View of Personalized Antitumor Vaccination [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Here, we report on a strategy to encapsulate cancer cell lysate in immunomodulating microparticles in view of their potential use in personalized anticancer vaccination. In a first step, cancer cell lysate is entrapped into porous calcium carbonate (CaCO3) microparticles by a coprecipitation reaction. Second, a polymer substituted with a small molecule TLR7/8-agonist is adorbed onto the surface of the microparticles. Relative to soluble cell lysate, microparticle encapsulation yielded higher uptake of cell lysate by dendritic cells in vitro. Also, microparticle-adsorbed polymeric TLR7/8-agonists retained their TLR-triggering capacity resulting in immunogenic vaccine particles. We anticipate this strategy might hold potential to turn patient-derived tumor tissue, comprising the patient’s own mutanome, into potent personalized anticancer vaccines.
@article{lybaert_cancer_2017,
title = {Cancer {Cell} {Lysate} {Entrapment} in {CaCO}3 {Engineered} with {Polymeric} {TLR}-{Agonists}: {Immune}-{Modulating} {Microparticles} in {View} of {Personalized} {Antitumor} {Vaccination}},
volume = {29},
issn = {0897-4756},
shorttitle = {Cancer {Cell} {Lysate} {Entrapment} in {CaCO}3 {Engineered} with {Polymeric} {TLR}-{Agonists}},
url = {http://dx.doi.org/10.1021/acs.chemmater.6b05062},
doi = {10.1021/acs.chemmater.6b05062},
abstract = {Here, we report on a strategy to encapsulate cancer cell lysate in immunomodulating microparticles in view of their potential use in personalized anticancer vaccination. In a first step, cancer cell lysate is entrapped into porous calcium carbonate (CaCO3) microparticles by a coprecipitation reaction. Second, a polymer substituted with a small molecule TLR7/8-agonist is adorbed onto the surface of the microparticles. Relative to soluble cell lysate, microparticle encapsulation yielded higher uptake of cell lysate by dendritic cells in vitro. Also, microparticle-adsorbed polymeric TLR7/8-agonists retained their TLR-triggering capacity resulting in immunogenic vaccine particles. We anticipate this strategy might hold potential to turn patient-derived tumor tissue, comprising the patient’s own mutanome, into potent personalized anticancer vaccines.},
number = {10},
urldate = {2017-10-23TZ},
journal = {Chemistry of Materials},
author = {Lybaert, Lien and Ryu, Keun Ah and Nuhn, Lutz and De Rycke, Riet and De Wever, Olivier and Chon, Alfred C. and Esser-Kahn, Aaron P. and De Geest, Bruno G.},
month = may,
year = {2017},
pages = {4209--4217}
}
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