@article{RN174,
   author = {M., IJff D. and van Veenendaal, T. M. and Majoie, H. J. and de Louw, A. J. and Jansen, J. F. and Aldenkamp, A. P.},
   title = {Cognitive effects of lacosamide as adjunctive therapy in refractory epilepsy},
   journal = {Acta Neurol Scand},
   volume = {131},
   number = {6},
   pages = {347-54},
   note = {IJff, D M
van Veenendaal, T M
Majoie, H J M
de Louw, A J A
Jansen, J F A
Aldenkamp, A P
eng
Clinical Trial
Denmark
2015/01/30 06:00
Acta Neurol Scand. 2015 Jun;131(6):347-54. doi: 10.1111/ane.12372. Epub 2015 Jan 28.},
   abstract = {BACKGROUND: Lacosamide (LCM) is a novel antiepileptic drug (AED) with potential benefit as adjunctive treatment in patients with partial-onset seizures. As yet, limited information on cognitive effects of LCM is available, especially in real-life settings. AIMS: In this open clinical prospective study, the cognitive effects of LCM were evaluated when used as adjunctive antiepileptic therapy in patients with refractory epilepsy. METHODS: We included 33 patients aged between 16 and 74 years (mean: 37 years). All patients had a localization-related epilepsy. Patients were assessed at baseline before starting LCM treatment and during follow-up when the optimal clinical dose was achieved. MATERIALS: Subjective complaints were evaluated using the SIDAED; effects on cognition were evaluated using the computerized visual searching task (CVST). RESULTS: The CVST showed significant faster information processing reaction times at the second evaluation (P = 0.013), which was not correlated with seizure control, type of epilepsy, age, gender, drug load, number of concomitant drugs, dose or duration of LCM treatment. On the SIDAED, patients complained more about their cognitive function at the second evaluation (P = 0.005). For the SIDAED, a positive correlation at follow-up was found between the total severity score and higher age (r = 0.375, P = 0.031), but not with epilepsy factors or treatment characteristics. DISCUSSION/CONLUSION: Screening of the cognitive effects of LCM showed that LCM does not have negative effects on information processing speed. As this is the most sensitive function for cognitive side effects of AEDs, LCM does not seem to induce the common negative cognitive effects. Remarkably, patients complained more, especially about their cognitive function, which is possible the 'doing better, feeling worse phenomenon'.},
   keywords = {Acetamides/*adverse effects/therapeutic use
Adolescent
Adult
Aged
Anticonvulsants/*adverse effects/therapeutic use
Cognition/*drug effects
Epilepsy/*drug therapy
Female
Humans
Lacosamide
Male
Middle Aged
Prospective Studies
Treatment Outcome
adverse effects
anti-epileptic drug
cognition
epilepsy},
   ISSN = {1600-0404 (Electronic)
0001-6314 (Linking)},
   DOI = {10.1111/ane.12372},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/25630655
https://onlinelibrary.wiley.com/doi/abs/10.1111/ane.12372},
   year = {2015},
   type = {Journal Article}
}

{"_id":"yNSqg4QkXNh3MhWHC","bibbaseid":"m-vanveenendaal-majoie-delouw-jansen-aldenkamp-cognitiveeffectsoflacosamideasadjunctivetherapyinrefractoryepilepsy-2015","authorIDs":["9uYiZAT4SGYEdwuhG","CHX5tw5dNmS7tFMt9","DoNKbgB55xkR6SehT","FEbMpouv9cRyJBZv3","GtL5d4iFpEuoJacN7","Jeci2sNzJiMSDeJvc","QqoDaykDZWJd9YuAu","TEAWLnKpXtQE8hs6C","dR2ye6bifAsonnNMz","eJ9fizm2KNxBgiNfF","hGdeHv63Gb3m6CybW","hShritfXo7Lzr2RkJ","jDvmx9aE5aohaf7P7","rQrciQZhPyL9ovwM8","zTR82AHQxLXLWt4wi"],"author_short":["M., I. D.","van Veenendaal, T. M.","Majoie, H. J.","de Louw, A. J.","Jansen, J. F.","Aldenkamp, A. P."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["M."],"firstnames":["IJff","D."],"suffixes":[]},{"propositions":["van"],"lastnames":["Veenendaal"],"firstnames":["T.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Majoie"],"firstnames":["H.","J."],"suffixes":[]},{"propositions":["de"],"lastnames":["Louw"],"firstnames":["A.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F."],"suffixes":[]},{"propositions":[],"lastnames":["Aldenkamp"],"firstnames":["A.","P."],"suffixes":[]}],"title":"Cognitive effects of lacosamide as adjunctive therapy in refractory epilepsy","journal":"Acta Neurol Scand","volume":"131","number":"6","pages":"347-54","note":"IJff, D M van Veenendaal, T M Majoie, H J M de Louw, A J A Jansen, J F A Aldenkamp, A P eng Clinical Trial Denmark 2015/01/30 06:00 Acta Neurol Scand. 2015 Jun;131(6):347-54. doi: 10.1111/ane.12372. Epub 2015 Jan 28.","abstract":"BACKGROUND: Lacosamide (LCM) is a novel antiepileptic drug (AED) with potential benefit as adjunctive treatment in patients with partial-onset seizures. As yet, limited information on cognitive effects of LCM is available, especially in real-life settings. AIMS: In this open clinical prospective study, the cognitive effects of LCM were evaluated when used as adjunctive antiepileptic therapy in patients with refractory epilepsy. METHODS: We included 33 patients aged between 16 and 74 years (mean: 37 years). All patients had a localization-related epilepsy. Patients were assessed at baseline before starting LCM treatment and during follow-up when the optimal clinical dose was achieved. MATERIALS: Subjective complaints were evaluated using the SIDAED; effects on cognition were evaluated using the computerized visual searching task (CVST). RESULTS: The CVST showed significant faster information processing reaction times at the second evaluation (P = 0.013), which was not correlated with seizure control, type of epilepsy, age, gender, drug load, number of concomitant drugs, dose or duration of LCM treatment. On the SIDAED, patients complained more about their cognitive function at the second evaluation (P = 0.005). For the SIDAED, a positive correlation at follow-up was found between the total severity score and higher age (r = 0.375, P = 0.031), but not with epilepsy factors or treatment characteristics. DISCUSSION/CONLUSION: Screening of the cognitive effects of LCM showed that LCM does not have negative effects on information processing speed. As this is the most sensitive function for cognitive side effects of AEDs, LCM does not seem to induce the common negative cognitive effects. Remarkably, patients complained more, especially about their cognitive function, which is possible the 'doing better, feeling worse phenomenon'.","keywords":"Acetamides/*adverse effects/therapeutic use Adolescent Adult Aged Anticonvulsants/*adverse effects/therapeutic use Cognition/*drug effects Epilepsy/*drug therapy Female Humans Lacosamide Male Middle Aged Prospective Studies Treatment Outcome adverse effects anti-epileptic drug cognition epilepsy","issn":"1600-0404 (Electronic) 0001-6314 (Linking)","doi":"10.1111/ane.12372","url":"http://www.ncbi.nlm.nih.gov/pubmed/25630655 https://onlinelibrary.wiley.com/doi/abs/10.1111/ane.12372","year":"2015","bibtex":"@article{RN174,\n author = {M., IJff D. and van Veenendaal, T. M. and Majoie, H. J. and de Louw, A. J. and Jansen, J. F. and Aldenkamp, A. P.},\n title = {Cognitive effects of lacosamide as adjunctive therapy in refractory epilepsy},\n journal = {Acta Neurol Scand},\n volume = {131},\n number = {6},\n pages = {347-54},\n note = {IJff, D M\nvan Veenendaal, T M\nMajoie, H J M\nde Louw, A J A\nJansen, J F A\nAldenkamp, A P\neng\nClinical Trial\nDenmark\n2015/01/30 06:00\nActa Neurol Scand. 2015 Jun;131(6):347-54. doi: 10.1111/ane.12372. Epub 2015 Jan 28.},\n abstract = {BACKGROUND: Lacosamide (LCM) is a novel antiepileptic drug (AED) with potential benefit as adjunctive treatment in patients with partial-onset seizures. As yet, limited information on cognitive effects of LCM is available, especially in real-life settings. AIMS: In this open clinical prospective study, the cognitive effects of LCM were evaluated when used as adjunctive antiepileptic therapy in patients with refractory epilepsy. METHODS: We included 33 patients aged between 16 and 74 years (mean: 37 years). All patients had a localization-related epilepsy. Patients were assessed at baseline before starting LCM treatment and during follow-up when the optimal clinical dose was achieved. MATERIALS: Subjective complaints were evaluated using the SIDAED; effects on cognition were evaluated using the computerized visual searching task (CVST). RESULTS: The CVST showed significant faster information processing reaction times at the second evaluation (P = 0.013), which was not correlated with seizure control, type of epilepsy, age, gender, drug load, number of concomitant drugs, dose or duration of LCM treatment. On the SIDAED, patients complained more about their cognitive function at the second evaluation (P = 0.005). For the SIDAED, a positive correlation at follow-up was found between the total severity score and higher age (r = 0.375, P = 0.031), but not with epilepsy factors or treatment characteristics. DISCUSSION/CONLUSION: Screening of the cognitive effects of LCM showed that LCM does not have negative effects on information processing speed. As this is the most sensitive function for cognitive side effects of AEDs, LCM does not seem to induce the common negative cognitive effects. 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