Development of oculomotor circuitry independent of hox3 genes. Ma, L., Grove, C. L, & Baker, R. Nature communications, 5:4221, January, 2014. Publisher: Nature Publishing Group![Development of oculomotor circuitry independent of hox3 genes. [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Hox genes have been shown to be essential in vertebrate neural circuit formation and their depletion has resulted in homeotic transformations with neuron loss and miswiring. Here we quantifiy four eye movements in the zebrafish mutant valentino and hox3 knockdowns, and find that contrary to the classical model, oculomotor circuits in hindbrain rhombomeres 5-6 develop and function independently of hox3 genes. All subgroups of oculomotor neurons are present, as well as their input and output connections. Ectopic connections are also established, targeting two specific subsets of horizontal neurons, and the resultant novel eye movements coexists with baseline behaviours. We conclude that the high expression of hox3 genes in rhombomeres 5-6 serves to prevent aberrant neuronal identity and behaviours, but does not appear to be necessary for a comprehensive assembly of functional oculomotor circuits.
@article{Ma2014,
title = {Development of oculomotor circuitry independent of hox3 genes.},
volume = {5},
issn = {2041-1723},
url = {http://www.nature.com.gate2.inist.fr/ncomms/2014/140625/ncomms5221/full/ncomms5221.html},
doi = {10.1038/ncomms5221},
abstract = {Hox genes have been shown to be essential in vertebrate neural circuit formation and their depletion has resulted in homeotic transformations with neuron loss and miswiring. Here we quantifiy four eye movements in the zebrafish mutant valentino and hox3 knockdowns, and find that contrary to the classical model, oculomotor circuits in hindbrain rhombomeres 5-6 develop and function independently of hox3 genes. All subgroups of oculomotor neurons are present, as well as their input and output connections. Ectopic connections are also established, targeting two specific subsets of horizontal neurons, and the resultant novel eye movements coexists with baseline behaviours. We conclude that the high expression of hox3 genes in rhombomeres 5-6 serves to prevent aberrant neuronal identity and behaviours, but does not appear to be necessary for a comprehensive assembly of functional oculomotor circuits.},
language = {en},
urldate = {2016-02-23},
journal = {Nature communications},
author = {Ma, Leung-Hang and Grove, Charlotte L and Baker, Robert},
month = jan,
year = {2014},
pmid = {24964400},
note = {Publisher: Nature Publishing Group},
keywords = {Animals, Eye Movements, Eye Movements: genetics, Gene Knockdown Techniques, Genes, Homeobox, Genes, Homeobox: genetics, Homeodomain Proteins, Homeodomain Proteins: genetics, Neural Pathways, Neural Pathways: growth \& development, Neural Pathways: metabolism, Rhombencephalon, Rhombencephalon: growth \& development, Rhombencephalon: metabolism, Zebrafish, Zebrafish Proteins, Zebrafish Proteins: genetics, neuroanatomy, zebrafish},
pages = {4221},
}
Downloads: 0
{"_id":"5zXjBtemTDmWAeLyg","bibbaseid":"ma-grove-baker-developmentofoculomotorcircuitryindependentofhox3genes-2014","author_short":["Ma, L.","Grove, C. L","Baker, R."],"bibdata":{"bibtype":"article","type":"article","title":"Development of oculomotor circuitry independent of hox3 genes.","volume":"5","issn":"2041-1723","url":"http://www.nature.com.gate2.inist.fr/ncomms/2014/140625/ncomms5221/full/ncomms5221.html","doi":"10.1038/ncomms5221","abstract":"Hox genes have been shown to be essential in vertebrate neural circuit formation and their depletion has resulted in homeotic transformations with neuron loss and miswiring. Here we quantifiy four eye movements in the zebrafish mutant valentino and hox3 knockdowns, and find that contrary to the classical model, oculomotor circuits in hindbrain rhombomeres 5-6 develop and function independently of hox3 genes. All subgroups of oculomotor neurons are present, as well as their input and output connections. Ectopic connections are also established, targeting two specific subsets of horizontal neurons, and the resultant novel eye movements coexists with baseline behaviours. We conclude that the high expression of hox3 genes in rhombomeres 5-6 serves to prevent aberrant neuronal identity and behaviours, but does not appear to be necessary for a comprehensive assembly of functional oculomotor circuits.","language":"en","urldate":"2016-02-23","journal":"Nature communications","author":[{"propositions":[],"lastnames":["Ma"],"firstnames":["Leung-Hang"],"suffixes":[]},{"propositions":[],"lastnames":["Grove"],"firstnames":["Charlotte","L"],"suffixes":[]},{"propositions":[],"lastnames":["Baker"],"firstnames":["Robert"],"suffixes":[]}],"month":"January","year":"2014","pmid":"24964400","note":"Publisher: Nature Publishing Group","keywords":"Animals, Eye Movements, Eye Movements: genetics, Gene Knockdown Techniques, Genes, Homeobox, Genes, Homeobox: genetics, Homeodomain Proteins, Homeodomain Proteins: genetics, Neural Pathways, Neural Pathways: growth & development, Neural Pathways: metabolism, Rhombencephalon, Rhombencephalon: growth & development, Rhombencephalon: metabolism, Zebrafish, Zebrafish Proteins, Zebrafish Proteins: genetics, neuroanatomy, zebrafish","pages":"4221","bibtex":"@article{Ma2014,\n\ttitle = {Development of oculomotor circuitry independent of hox3 genes.},\n\tvolume = {5},\n\tissn = {2041-1723},\n\turl = {http://www.nature.com.gate2.inist.fr/ncomms/2014/140625/ncomms5221/full/ncomms5221.html},\n\tdoi = {10.1038/ncomms5221},\n\tabstract = {Hox genes have been shown to be essential in vertebrate neural circuit formation and their depletion has resulted in homeotic transformations with neuron loss and miswiring. Here we quantifiy four eye movements in the zebrafish mutant valentino and hox3 knockdowns, and find that contrary to the classical model, oculomotor circuits in hindbrain rhombomeres 5-6 develop and function independently of hox3 genes. All subgroups of oculomotor neurons are present, as well as their input and output connections. Ectopic connections are also established, targeting two specific subsets of horizontal neurons, and the resultant novel eye movements coexists with baseline behaviours. We conclude that the high expression of hox3 genes in rhombomeres 5-6 serves to prevent aberrant neuronal identity and behaviours, but does not appear to be necessary for a comprehensive assembly of functional oculomotor circuits.},\n\tlanguage = {en},\n\turldate = {2016-02-23},\n\tjournal = {Nature communications},\n\tauthor = {Ma, Leung-Hang and Grove, Charlotte L and Baker, Robert},\n\tmonth = jan,\n\tyear = {2014},\n\tpmid = {24964400},\n\tnote = {Publisher: Nature Publishing Group},\n\tkeywords = {Animals, Eye Movements, Eye Movements: genetics, Gene Knockdown Techniques, Genes, Homeobox, Genes, Homeobox: genetics, Homeodomain Proteins, Homeodomain Proteins: genetics, Neural Pathways, Neural Pathways: growth \\& development, Neural Pathways: metabolism, Rhombencephalon, Rhombencephalon: growth \\& development, Rhombencephalon: metabolism, Zebrafish, Zebrafish Proteins, Zebrafish Proteins: genetics, neuroanatomy, zebrafish},\n\tpages = {4221},\n}\n\n\n\n","author_short":["Ma, L.","Grove, C. L","Baker, R."],"key":"Ma2014","id":"Ma2014","bibbaseid":"ma-grove-baker-developmentofoculomotorcircuitryindependentofhox3genes-2014","role":"author","urls":{"Paper":"http://www.nature.com.gate2.inist.fr/ncomms/2014/140625/ncomms5221/full/ncomms5221.html"},"keyword":["Animals","Eye Movements","Eye Movements: genetics","Gene Knockdown Techniques","Genes","Homeobox","Genes","Homeobox: genetics","Homeodomain Proteins","Homeodomain Proteins: genetics","Neural Pathways","Neural Pathways: growth & development","Neural Pathways: metabolism","Rhombencephalon","Rhombencephalon: growth & development","Rhombencephalon: metabolism","Zebrafish","Zebrafish Proteins","Zebrafish Proteins: genetics","neuroanatomy","zebrafish"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://bibbase.org/zotero/sumbre","dataSources":["FTTT6MtwhkNF2aJCF"],"keywords":["animals","eye movements","eye movements: genetics","gene knockdown techniques","genes","homeobox","genes","homeobox: genetics","homeodomain proteins","homeodomain proteins: genetics","neural pathways","neural pathways: growth & development","neural pathways: metabolism","rhombencephalon","rhombencephalon: growth & development","rhombencephalon: metabolism","zebrafish","zebrafish proteins","zebrafish proteins: genetics","neuroanatomy","zebrafish"],"search_terms":["development","oculomotor","circuitry","independent","hox3","genes","ma","grove","baker"],"title":"Development of oculomotor circuitry independent of hox3 genes.","year":2014}