Aggregation-Induced Emission Active Polyacrylates via Cu-Mediated Reversible Deactivation Radical Polymerization with Bioimaging Applications. Ma, C., Han, T., Kang, M., Liarou, E., Wemyss, A., Efstathiou, S., Tang, B. Z., & Haddleton, D. M. ACS MACRO LETTERS, 9(5):769–775, May, 2020. doi abstract bibtex The introduction of aggregation-induced emission (AIE) moieties into polymers results in smart materials with AIE characteristics, expanding their scope of applications. Herein, well-defined polymers with controlled molecular weight, low dispersity, and high end-group fidelity are produced via copper(0)-mediated reversible-deactivation radical polymerizations (Cu(0)-RDRPs). An AIE-containing initiator tetraphenylethene bromoisobutyrate (TPEBIB) has been synthesized, fully characterized, and utilized for the construction of different polyacrylate homopolymers and block copolymers bearing the TPE group with a range of molecular weights and architectures. All of the polymers exhibited AIE behavior. Notably, the hydrophobic TPE-poly(tert-butyl acrylate) (TPE-PtBA)containing block copolymers are transformed to TPE-poly(acrylic acid) (TPEPAA)-based amphiphilic copolymers by facile deprotection, enabling pH-tunable self-assembly in aqueous media to give fluorescent nanoparticles with various sizes. The low cytotoxicity, high specificity, and excellent photostability render them promising candidates as lysosome-specific probes in biological imaging applications.
@article{ma_aggregation-induced_2020,
title = {Aggregation-{Induced} {Emission} {Active} {Polyacrylates} via {Cu}-{Mediated} {Reversible} {Deactivation} {Radical} {Polymerization} with {Bioimaging} {Applications}},
volume = {9},
issn = {2161-1653},
doi = {10.1021/acsmacrolett.0c00281},
abstract = {The introduction of aggregation-induced emission (AIE) moieties into polymers results in smart materials with AIE characteristics, expanding their scope of applications. Herein, well-defined polymers with controlled molecular weight, low dispersity, and high end-group fidelity are produced via copper(0)-mediated reversible-deactivation radical polymerizations (Cu(0)-RDRPs). An AIE-containing initiator tetraphenylethene bromoisobutyrate (TPEBIB) has been synthesized, fully characterized, and utilized for the construction of different polyacrylate homopolymers and block copolymers bearing the TPE group with a range of molecular weights and architectures. All of the polymers exhibited AIE behavior. Notably, the hydrophobic TPE-poly(tert-butyl acrylate) (TPE-PtBA)containing block copolymers are transformed to TPE-poly(acrylic acid) (TPEPAA)-based amphiphilic copolymers by facile deprotection, enabling pH-tunable self-assembly in aqueous media to give fluorescent nanoparticles with various sizes. The low cytotoxicity, high specificity, and excellent photostability render them promising candidates as lysosome-specific probes in biological imaging applications.},
number = {5},
urldate = {2020-06-15},
journal = {ACS MACRO LETTERS},
author = {Ma, Congkai and Han, Ting and Kang, Miaomiao and Liarou, Evelina and Wemyss, Alan and Efstathiou, Spyridon and Tang, Ben Zhong and Haddleton, David M.},
month = may,
year = {2020},
pages = {769--775},
}
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Herein, well-defined polymers with controlled molecular weight, low dispersity, and high end-group fidelity are produced via copper(0)-mediated reversible-deactivation radical polymerizations (Cu(0)-RDRPs). An AIE-containing initiator tetraphenylethene bromoisobutyrate (TPEBIB) has been synthesized, fully characterized, and utilized for the construction of different polyacrylate homopolymers and block copolymers bearing the TPE group with a range of molecular weights and architectures. All of the polymers exhibited AIE behavior. Notably, the hydrophobic TPE-poly(tert-butyl acrylate) (TPE-PtBA)containing block copolymers are transformed to TPE-poly(acrylic acid) (TPEPAA)-based amphiphilic copolymers by facile deprotection, enabling pH-tunable self-assembly in aqueous media to give fluorescent nanoparticles with various sizes. 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