{"_id":"Acb3LhWrxHWCt8Poj","bibbaseid":"ma-jonsson-aryal-deveylder-hamant-bhalerao-endoreplicationmediatescellsizecontrolviamechanochemicalsignalingfromcellwall-2022","author_short":["Ma, Y.","Jonsson, K.","Aryal, B.","De Veylder, L.","Hamant, O.","Bhalerao, R. P."],"bibdata":{"bibtype":"article","type":"article","title":"Endoreplication mediates cell size control via mechanochemical signaling from cell wall","volume":"8","url":"https://www.science.org/doi/10.1126/sciadv.abq2047","doi":"10.1126/sciadv.abq2047","abstract":"Endoreplication is an evolutionarily conserved mechanism for increasing nuclear DNA content (ploidy). Ploidy frequently scales with final cell and organ size, suggesting a key role for endoreplication in these processes. However, exceptions exist, and, consequently, the endoreplication-size nexus remains enigmatic. Here, we show that prolonged tissue folding at the apical hook in Arabidopsis requires endoreplication asymmetry under the control of an auxin gradient. We identify a molecular pathway linking endoreplication levels to cell size through cell wall remodeling and stiffness modulation. We find that endoreplication is not only permissive for growth: Endoreplication reduction enhances wall stiffening, actively reducing cell size. The cell wall integrity kinase THESEUS plays a key role in this feedback loop. Our data thus explain the nonlinearity between ploidy levels and size while also providing a molecular mechanism linking mechanochemical signaling with endoreplication-mediated dynamic control of cell growth.","number":"49","urldate":"2022-12-16","journal":"Science Advances","author":[{"propositions":[],"lastnames":["Ma"],"firstnames":["Yuan"],"suffixes":[]},{"propositions":[],"lastnames":["Jonsson"],"firstnames":["Kristoffer"],"suffixes":[]},{"propositions":[],"lastnames":["Aryal"],"firstnames":["Bibek"],"suffixes":[]},{"propositions":[],"lastnames":["De","Veylder"],"firstnames":["Lieven"],"suffixes":[]},{"propositions":[],"lastnames":["Hamant"],"firstnames":["Olivier"],"suffixes":[]},{"propositions":[],"lastnames":["Bhalerao"],"firstnames":["Rishikesh","P."],"suffixes":[]}],"month":"December","year":"2022","pages":"eabq2047","bibtex":"@article{ma_endoreplication_2022,\n\ttitle = {Endoreplication mediates cell size control via mechanochemical signaling from cell wall},\n\tvolume = {8},\n\turl = {https://www.science.org/doi/10.1126/sciadv.abq2047},\n\tdoi = {10.1126/sciadv.abq2047},\n\tabstract = {Endoreplication is an evolutionarily conserved mechanism for increasing nuclear DNA content (ploidy). Ploidy frequently scales with final cell and organ size, suggesting a key role for endoreplication in these processes. However, exceptions exist, and, consequently, the endoreplication-size nexus remains enigmatic. Here, we show that prolonged tissue folding at the apical hook in Arabidopsis requires endoreplication asymmetry under the control of an auxin gradient. We identify a molecular pathway linking endoreplication levels to cell size through cell wall remodeling and stiffness modulation. We find that endoreplication is not only permissive for growth: Endoreplication reduction enhances wall stiffening, actively reducing cell size. The cell wall integrity kinase THESEUS plays a key role in this feedback loop. Our data thus explain the nonlinearity between ploidy levels and size while also providing a molecular mechanism linking mechanochemical signaling with endoreplication-mediated dynamic control of cell growth.},\n\tnumber = {49},\n\turldate = {2022-12-16},\n\tjournal = {Science Advances},\n\tauthor = {Ma, Yuan and Jonsson, Kristoffer and Aryal, Bibek and De Veylder, Lieven and Hamant, Olivier and Bhalerao, Rishikesh P.},\n\tmonth = dec,\n\tyear = {2022},\n\tpages = {eabq2047},\n}\n\n\n\n","author_short":["Ma, Y.","Jonsson, K.","Aryal, B.","De Veylder, L.","Hamant, O.","Bhalerao, R. P."],"key":"ma_endoreplication_2022","id":"ma_endoreplication_2022","bibbaseid":"ma-jonsson-aryal-deveylder-hamant-bhalerao-endoreplicationmediatescellsizecontrolviamechanochemicalsignalingfromcellwall-2022","role":"author","urls":{"Paper":"https://www.science.org/doi/10.1126/sciadv.abq2047"},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/zotero/upscpub","dataSources":["9cGcv2t8pRzC92kzs"],"keywords":[],"search_terms":["endoreplication","mediates","cell","size","control","via","mechanochemical","signaling","cell","wall","ma","jonsson","aryal","de veylder","hamant","bhalerao"],"title":"Endoreplication mediates cell size control via mechanochemical signaling from cell wall","year":2022}