HIV, the gut microbiome and clinical outcomes, a systematic review. Mac Cann, R., Newman, E., Devane, D., Sabin, C., Cotter, A. G., Landay, A., O’Toole, P. W., & Mallon, P. W. PLOS ONE, 19(12):e0308859, December, 2024. ![HIV, the gut microbiome and clinical outcomes, a systematic review [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Background Effective antiretroviral therapy (ART) has improved the life expectancy of people with HIV (PWH). However, this population is now experiencing accelerated age‐related comorbidities, contributed to by chronic immune activation and inflammation, with dysbiosis of the gut microbiome also implicated. Method We conducted a systematic literature search of PubMed, Embase, Scopus, Cochrane reviews and international conference abstracts for articles that examined for the following non-communicable diseases (NCDs); cardiovascular disease, cancer, frailty, metabolic, bone, renal and neurocognitive disease, in PWH aged \textgreater18 years. Studies were included that measured gut microbiome diversity and composition, microbial translocation markers or microbial metabolite markers. Results In all, 567 articles were identified and screened of which 87 full‐text articles were assessed for eligibility and 56 were included in the final review. The data suggest a high burden NCD, in particular cardiovascular and metabolic disease in PWH. Alterations in bacterial diversity and structure varied by NCD type, but a general trend in reduced diversity was seen together with alterations in bacterial abundances between different NCD. Lipopolysaccharide was the most commonly investigated marker of microbial translocation across NCD followed by soluble CD14. Short-chain fatty acids, tryptophan and choline metabolites were associated with cardiovascular outcomes and also associated with chronic liver disease (CLD). Conclusions This systematic review is the first to summarise the evidence for the association between gut microbiome dysbiosis and NCDs in PWH. Understanding this interaction will provide insights into the pathogenesis of many NCD and help develop novel diagnostic and therapeutic strategies for PWH.
@article{mac_cann_hiv_2024,
title = {{HIV}, the gut microbiome and clinical outcomes, a systematic review},
volume = {19},
issn = {1932-6203},
url = {https://dx.plos.org/10.1371/journal.pone.0308859},
doi = {10.1371/journal.pone.0308859},
abstract = {Background
Effective antiretroviral therapy (ART) has improved the life expectancy of people with HIV (PWH). However, this population is now experiencing accelerated age‐related comorbidities, contributed to by chronic immune activation and inflammation, with dysbiosis of the gut microbiome also implicated.
Method
We conducted a systematic literature search of PubMed, Embase, Scopus, Cochrane reviews and international conference abstracts for articles that examined for the following non-communicable diseases (NCDs); cardiovascular disease, cancer, frailty, metabolic, bone, renal and neurocognitive disease, in PWH aged {\textgreater}18 years. Studies were included that measured gut microbiome diversity and composition, microbial translocation markers or microbial metabolite markers.
Results
In all, 567 articles were identified and screened of which 87 full‐text articles were assessed for eligibility and 56 were included in the final review. The data suggest a high burden NCD, in particular cardiovascular and metabolic disease in PWH. Alterations in bacterial diversity and structure varied by NCD type, but a general trend in reduced diversity was seen together with alterations in bacterial abundances between different NCD. Lipopolysaccharide was the most commonly investigated marker of microbial translocation across NCD followed by soluble CD14. Short-chain fatty acids, tryptophan and choline metabolites were associated with cardiovascular outcomes and also associated with chronic liver disease (CLD).
Conclusions
This systematic review is the first to summarise the evidence for the association between gut microbiome dysbiosis and NCDs in PWH. Understanding this interaction will provide insights into the pathogenesis of many NCD and help develop novel diagnostic and therapeutic strategies for PWH.},
language = {en},
number = {12},
urldate = {2025-10-04},
journal = {PLOS ONE},
author = {Mac Cann, Rachel and Newman, Ellen and Devane, Declan and Sabin, Caroline and Cotter, Aoife G. and Landay, Alan and O’Toole, Paul W. and Mallon, Patrick W.},
editor = {Chuang, Wan-Long},
month = dec,
year = {2024},
pages = {e0308859},
}
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Method We conducted a systematic literature search of PubMed, Embase, Scopus, Cochrane reviews and international conference abstracts for articles that examined for the following non-communicable diseases (NCDs); cardiovascular disease, cancer, frailty, metabolic, bone, renal and neurocognitive disease, in PWH aged \\textgreater18 years. Studies were included that measured gut microbiome diversity and composition, microbial translocation markers or microbial metabolite markers. Results In all, 567 articles were identified and screened of which 87 full‐text articles were assessed for eligibility and 56 were included in the final review. The data suggest a high burden NCD, in particular cardiovascular and metabolic disease in PWH. Alterations in bacterial diversity and structure varied by NCD type, but a general trend in reduced diversity was seen together with alterations in bacterial abundances between different NCD. Lipopolysaccharide was the most commonly investigated marker of microbial translocation across NCD followed by soluble CD14. Short-chain fatty acids, tryptophan and choline metabolites were associated with cardiovascular outcomes and also associated with chronic liver disease (CLD). Conclusions This systematic review is the first to summarise the evidence for the association between gut microbiome dysbiosis and NCDs in PWH. Understanding this interaction will provide insights into the pathogenesis of many NCD and help develop novel diagnostic and therapeutic strategies for PWH.","language":"en","number":"12","urldate":"2025-10-04","journal":"PLOS ONE","author":[{"propositions":[],"lastnames":["Mac","Cann"],"firstnames":["Rachel"],"suffixes":[]},{"propositions":[],"lastnames":["Newman"],"firstnames":["Ellen"],"suffixes":[]},{"propositions":[],"lastnames":["Devane"],"firstnames":["Declan"],"suffixes":[]},{"propositions":[],"lastnames":["Sabin"],"firstnames":["Caroline"],"suffixes":[]},{"propositions":[],"lastnames":["Cotter"],"firstnames":["Aoife","G."],"suffixes":[]},{"propositions":[],"lastnames":["Landay"],"firstnames":["Alan"],"suffixes":[]},{"propositions":[],"lastnames":["O’Toole"],"firstnames":["Paul","W."],"suffixes":[]},{"propositions":[],"lastnames":["Mallon"],"firstnames":["Patrick","W."],"suffixes":[]}],"editor":[{"propositions":[],"lastnames":["Chuang"],"firstnames":["Wan-Long"],"suffixes":[]}],"month":"December","year":"2024","pages":"e0308859","bibtex":"@article{mac_cann_hiv_2024,\n\ttitle = {{HIV}, the gut microbiome and clinical outcomes, a systematic review},\n\tvolume = {19},\n\tissn = {1932-6203},\n\turl = {https://dx.plos.org/10.1371/journal.pone.0308859},\n\tdoi = {10.1371/journal.pone.0308859},\n\tabstract = {Background \n Effective antiretroviral therapy (ART) has improved the life expectancy of people with HIV (PWH). However, this population is now experiencing accelerated age‐related comorbidities, contributed to by chronic immune activation and inflammation, with dysbiosis of the gut microbiome also implicated. \n \n \n Method \n We conducted a systematic literature search of PubMed, Embase, Scopus, Cochrane reviews and international conference abstracts for articles that examined for the following non-communicable diseases (NCDs); cardiovascular disease, cancer, frailty, metabolic, bone, renal and neurocognitive disease, in PWH aged {\\textgreater}18 years. Studies were included that measured gut microbiome diversity and composition, microbial translocation markers or microbial metabolite markers. \n \n \n Results \n In all, 567 articles were identified and screened of which 87 full‐text articles were assessed for eligibility and 56 were included in the final review. The data suggest a high burden NCD, in particular cardiovascular and metabolic disease in PWH. Alterations in bacterial diversity and structure varied by NCD type, but a general trend in reduced diversity was seen together with alterations in bacterial abundances between different NCD. Lipopolysaccharide was the most commonly investigated marker of microbial translocation across NCD followed by soluble CD14. Short-chain fatty acids, tryptophan and choline metabolites were associated with cardiovascular outcomes and also associated with chronic liver disease (CLD). \n \n \n Conclusions \n This systematic review is the first to summarise the evidence for the association between gut microbiome dysbiosis and NCDs in PWH. Understanding this interaction will provide insights into the pathogenesis of many NCD and help develop novel diagnostic and therapeutic strategies for PWH.},\n\tlanguage = {en},\n\tnumber = {12},\n\turldate = {2025-10-04},\n\tjournal = {PLOS ONE},\n\tauthor = {Mac Cann, Rachel and Newman, Ellen and Devane, Declan and Sabin, Caroline and Cotter, Aoife G. and Landay, Alan and O’Toole, Paul W. and Mallon, Patrick W.},\n\teditor = {Chuang, Wan-Long},\n\tmonth = dec,\n\tyear = {2024},\n\tpages = {e0308859},\n}\n\n","author_short":["Mac Cann, R.","Newman, E.","Devane, D.","Sabin, C.","Cotter, A. G.","Landay, A.","O’Toole, P. W.","Mallon, P. W."],"editor_short":["Chuang, W."],"key":"mac_cann_hiv_2024","id":"mac_cann_hiv_2024","bibbaseid":"maccann-newman-devane-sabin-cotter-landay-otoole-mallon-hivthegutmicrobiomeandclinicaloutcomesasystematicreview-2024","role":"author","urls":{"Paper":"https://dx.plos.org/10.1371/journal.pone.0308859"},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://api.zotero.org/groups/2612609/items?key=q7jcbB1mWWw3v8QF5sWsA8qX&format=bibtex&limit=100","dataSources":["mGrzSHoSZhFtkoor2"],"keywords":[],"search_terms":["hiv","gut","microbiome","clinical","outcomes","systematic","review","mac cann","newman","devane","sabin","cotter","landay","o’toole","mallon"],"title":"HIV, the gut microbiome and clinical outcomes, a systematic review","year":2024}