Synthesis of carbohydrate derivatives using solid-phase work-up and scavenging techniques. MacCoss, R., N., Brennan, P., E., & Ley, S., V. Organic and Biomolecular Chemistry, 1(12):2029-2031, Royal Society of Chemistry, 2003.
Paper
Website doi abstract bibtex Methods to allow the clean prepn. of oligosaccharides were investigated using techniques that do not require conventional column chromatog. or an aq. work-up. The route was designed to provide rapid access to oligosaccharides and is suitable for automation and parallel library formation. The research has focused on the glycosidations of a range of glycosyl acceptors with various selenophenyl glycosyl donors using iodine as an activator in the presence of DTBMP, a hindered org. base. Hydroxyl-contg. contaminants were removed by scavenging with polymer-supported tosyl chloride. [on SciFinder(R)]
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abstract = {Methods to allow the clean prepn. of oligosaccharides were investigated using techniques that do not require conventional column chromatog. or an aq. work-up. The route was designed to provide rapid access to oligosaccharides and is suitable for automation and parallel library formation. The research has focused on the glycosidations of a range of glycosyl acceptors with various selenophenyl glycosyl donors using iodine as an activator in the presence of DTBMP, a hindered org. base. Hydroxyl-contg. contaminants were removed by scavenging with polymer-supported tosyl chloride. [on SciFinder(R)]},
bibtype = {article},
author = {MacCoss, Rachel N. and Brennan, Paul E. and Ley, Steven V.},
doi = {10.1039/b303951j},
journal = {Organic and Biomolecular Chemistry},
number = {12}
}
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