Induction of immunologic memory by conjugated vs plain meningococcal c polysaccharide vaccine in toddlers: A randomized controlled trial. MacDonald NE, Halperin SA, Law BJ, Forrest B, Danzig LE, & Granoff DM JAMA, 280(19):1685–1689, November, 1998. ![Induction of immunologic memory by conjugated vs plain meningococcal c polysaccharide vaccine in toddlers: A randomized controlled trial [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Context.— Meningococcal polysaccharide vaccines are not used routinely in infants and toddlers, the groups at highest risk of invasive disease, because of poor immunologic responses to the Neisseria meningitidis serogroup C polysaccharide in these age groups. Meningococcal C conjugate vaccines offer the prospect of circumventing this problem.Objective.— To assess the immunogenicity and the induction of immunologic memory in toddlers by meningococcal C conjugate vaccine.Design.— A multicenter, randomized, observer-blinded controlled trial.Setting.— Urban and suburban family medicine or pediatric practices.Participants.— Two hundred eleven healthy toddlers aged 15 to 23 months.Intervention.— Two injections at 2 months apart of meningococcal C conjugate (group 1, n=69), plain meningococcal polysaccharide (group 2, n=72), or hepatitis B virus vaccine (group 3, n=70). All toddlers received a follow-up dose of plain meningococcal polysaccharide vaccine 12 months later.Main Outcome Measures.— IgG meningococcal C anticapsular antibody concentrations determined by enzyme-linked immunosorbent assay and complement-mediated bactericidal antibody.Results.— In group 1, the magnitude of the IgG response to meningococcal C conjugate vaccine was more than 4-fold higher after dose 1 and more than 10-fold higher after dose 2 compared with meningococcal polysaccharide vaccine (group 2) (P\textless.001). Higher titers persisted in the meningococcal C conjugate group for at least 12 months (P\textless.001). Group 1, primed with meningococcal C conjugate, had 25-fold higher IgG responses to the meningococcal polysaccharide 1-year booster dose than the controls who had received hepatitis B virus vaccine initially and were given meningococcal polysaccharide vaccine 1 year later for the first time (P\textless.001). In contrast, group 2, primed with meningococcal polysaccharide, had a 2-fold lower response to the 1-year booster meningococcal polysaccharide dose than the hepatitis B virus control group (P=.006). Serum bactericidal responses paralleled the enzyme-linked immunosorbent assay responses.Conclusions.— Immunization of toddlers with meningococcal C conjugate vaccine induces high titers of anticapsular and bactericidal antibody. Furthermore, this vaccine induces immunologic memory to meningococcal C polysaccharide. In contrast, meningococcal polysaccharide vaccine is less immunogenic than the conjugate vaccine and also induces a hyporesponsive state that persists for at least 12 months.
@article{macdonald_ne_induction_1998,
title = {Induction of immunologic memory by conjugated vs plain meningococcal c polysaccharide vaccine in toddlers: {A} randomized controlled trial},
volume = {280},
issn = {0098-7484},
shorttitle = {Induction of immunologic memory by conjugated vs plain meningococcal c polysaccharide vaccine in toddlers},
url = {http://dx.doi.org/10.1001/jama.280.19.1685},
doi = {10.1001/jama.280.19.1685},
abstract = {Context.— Meningococcal polysaccharide vaccines are not used routinely in infants
and toddlers, the groups at highest risk of invasive disease, because of poor
immunologic responses to the Neisseria meningitidis
serogroup C polysaccharide in these age groups. Meningococcal C conjugate
vaccines offer the prospect of circumventing this problem.Objective.— To assess the immunogenicity and the induction of immunologic memory
in toddlers by meningococcal C conjugate vaccine.Design.— A multicenter, randomized, observer-blinded controlled trial.Setting.— Urban and suburban family medicine or pediatric practices.Participants.— Two hundred eleven healthy toddlers aged 15 to 23 months.Intervention.— Two injections at 2 months apart of meningococcal C conjugate (group
1, n=69), plain meningococcal polysaccharide (group 2, n=72), or hepatitis
B virus vaccine (group 3, n=70). All toddlers received a follow-up dose of
plain meningococcal polysaccharide vaccine 12 months later.Main Outcome Measures.— IgG meningococcal C anticapsular antibody concentrations determined
by enzyme-linked immunosorbent assay and complement-mediated bactericidal
antibody.Results.— In group 1, the magnitude of the IgG response to meningococcal C conjugate
vaccine was more than 4-fold higher after dose 1 and more than 10-fold higher
after dose 2 compared with meningococcal polysaccharide vaccine (group 2)
(P{\textless}.001). Higher titers persisted in the meningococcal
C conjugate group for at least 12 months (P{\textless}.001).
Group 1, primed with meningococcal C conjugate, had 25-fold higher IgG responses
to the meningococcal polysaccharide 1-year booster dose than the controls
who had received hepatitis B virus vaccine initially and were given meningococcal
polysaccharide vaccine 1 year later for the first time (P{\textless}.001). In contrast, group 2, primed with meningococcal polysaccharide,
had a 2-fold lower response to the 1-year booster meningococcal polysaccharide
dose than the hepatitis B virus control group (P=.006).
Serum bactericidal responses paralleled the enzyme-linked immunosorbent assay
responses.Conclusions.— Immunization of toddlers with meningococcal C conjugate vaccine induces
high titers of anticapsular and bactericidal antibody. Furthermore, this vaccine
induces immunologic memory to meningococcal C polysaccharide. In contrast,
meningococcal polysaccharide vaccine is less immunogenic than the conjugate
vaccine and also induces a hyporesponsive state that persists for at least
12 months.},
number = {19},
urldate = {2014-08-24},
journal = {JAMA},
author = {{MacDonald NE} and {Halperin SA} and {Law BJ} and {Forrest B} and {Danzig LE} and {Granoff DM}},
month = nov,
year = {1998},
pages = {1685--1689},
}
Downloads: 0
{"_id":"oDTpQsCrtgnaF6RoD","bibbaseid":"macdonaldne-halperinsa-lawbj-forrestb-danzigle-granoffdm-inductionofimmunologicmemorybyconjugatedvsplainmeningococcalcpolysaccharidevaccineintoddlersarandomizedcontrolledtrial-1998","author_short":["MacDonald NE","Halperin SA","Law BJ","Forrest B","Danzig LE","Granoff DM"],"bibdata":{"bibtype":"article","type":"article","title":"Induction of immunologic memory by conjugated vs plain meningococcal c polysaccharide vaccine in toddlers: A randomized controlled trial","volume":"280","issn":"0098-7484","shorttitle":"Induction of immunologic memory by conjugated vs plain meningococcal c polysaccharide vaccine in toddlers","url":"http://dx.doi.org/10.1001/jama.280.19.1685","doi":"10.1001/jama.280.19.1685","abstract":"Context.— Meningococcal polysaccharide vaccines are not used routinely in infants and toddlers, the groups at highest risk of invasive disease, because of poor immunologic responses to the Neisseria meningitidis serogroup C polysaccharide in these age groups. Meningococcal C conjugate vaccines offer the prospect of circumventing this problem.Objective.— To assess the immunogenicity and the induction of immunologic memory in toddlers by meningococcal C conjugate vaccine.Design.— A multicenter, randomized, observer-blinded controlled trial.Setting.— Urban and suburban family medicine or pediatric practices.Participants.— Two hundred eleven healthy toddlers aged 15 to 23 months.Intervention.— Two injections at 2 months apart of meningococcal C conjugate (group 1, n=69), plain meningococcal polysaccharide (group 2, n=72), or hepatitis B virus vaccine (group 3, n=70). All toddlers received a follow-up dose of plain meningococcal polysaccharide vaccine 12 months later.Main Outcome Measures.— IgG meningococcal C anticapsular antibody concentrations determined by enzyme-linked immunosorbent assay and complement-mediated bactericidal antibody.Results.— In group 1, the magnitude of the IgG response to meningococcal C conjugate vaccine was more than 4-fold higher after dose 1 and more than 10-fold higher after dose 2 compared with meningococcal polysaccharide vaccine (group 2) (P\\textless.001). Higher titers persisted in the meningococcal C conjugate group for at least 12 months (P\\textless.001). Group 1, primed with meningococcal C conjugate, had 25-fold higher IgG responses to the meningococcal polysaccharide 1-year booster dose than the controls who had received hepatitis B virus vaccine initially and were given meningococcal polysaccharide vaccine 1 year later for the first time (P\\textless.001). In contrast, group 2, primed with meningococcal polysaccharide, had a 2-fold lower response to the 1-year booster meningococcal polysaccharide dose than the hepatitis B virus control group (P=.006). Serum bactericidal responses paralleled the enzyme-linked immunosorbent assay responses.Conclusions.— Immunization of toddlers with meningococcal C conjugate vaccine induces high titers of anticapsular and bactericidal antibody. Furthermore, this vaccine induces immunologic memory to meningococcal C polysaccharide. In contrast, meningococcal polysaccharide vaccine is less immunogenic than the conjugate vaccine and also induces a hyporesponsive state that persists for at least 12 months.","number":"19","urldate":"2014-08-24","journal":"JAMA","author":[{"firstnames":[],"propositions":[],"lastnames":["MacDonald NE"],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Halperin SA"],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Law BJ"],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Forrest B"],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Danzig LE"],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Granoff DM"],"suffixes":[]}],"month":"November","year":"1998","pages":"1685–1689","bibtex":"@article{macdonald_ne_induction_1998,\n\ttitle = {Induction of immunologic memory by conjugated vs plain meningococcal c polysaccharide vaccine in toddlers: {A} randomized controlled trial},\n\tvolume = {280},\n\tissn = {0098-7484},\n\tshorttitle = {Induction of immunologic memory by conjugated vs plain meningococcal c polysaccharide vaccine in toddlers},\n\turl = {http://dx.doi.org/10.1001/jama.280.19.1685},\n\tdoi = {10.1001/jama.280.19.1685},\n\tabstract = {Context.— Meningococcal polysaccharide vaccines are not used routinely in infants\nand toddlers, the groups at highest risk of invasive disease, because of poor\nimmunologic responses to the Neisseria meningitidis\nserogroup C polysaccharide in these age groups. Meningococcal C conjugate\nvaccines offer the prospect of circumventing this problem.Objective.— To assess the immunogenicity and the induction of immunologic memory\nin toddlers by meningococcal C conjugate vaccine.Design.— A multicenter, randomized, observer-blinded controlled trial.Setting.— Urban and suburban family medicine or pediatric practices.Participants.— Two hundred eleven healthy toddlers aged 15 to 23 months.Intervention.— Two injections at 2 months apart of meningococcal C conjugate (group\n1, n=69), plain meningococcal polysaccharide (group 2, n=72), or hepatitis\nB virus vaccine (group 3, n=70). All toddlers received a follow-up dose of\nplain meningococcal polysaccharide vaccine 12 months later.Main Outcome Measures.— IgG meningococcal C anticapsular antibody concentrations determined\nby enzyme-linked immunosorbent assay and complement-mediated bactericidal\nantibody.Results.— In group 1, the magnitude of the IgG response to meningococcal C conjugate\nvaccine was more than 4-fold higher after dose 1 and more than 10-fold higher\nafter dose 2 compared with meningococcal polysaccharide vaccine (group 2)\n(P{\\textless}.001). Higher titers persisted in the meningococcal\nC conjugate group for at least 12 months (P{\\textless}.001).\nGroup 1, primed with meningococcal C conjugate, had 25-fold higher IgG responses\nto the meningococcal polysaccharide 1-year booster dose than the controls\nwho had received hepatitis B virus vaccine initially and were given meningococcal\npolysaccharide vaccine 1 year later for the first time (P{\\textless}.001). In contrast, group 2, primed with meningococcal polysaccharide,\nhad a 2-fold lower response to the 1-year booster meningococcal polysaccharide\ndose than the hepatitis B virus control group (P=.006).\nSerum bactericidal responses paralleled the enzyme-linked immunosorbent assay\nresponses.Conclusions.— Immunization of toddlers with meningococcal C conjugate vaccine induces\nhigh titers of anticapsular and bactericidal antibody. Furthermore, this vaccine\ninduces immunologic memory to meningococcal C polysaccharide. In contrast,\nmeningococcal polysaccharide vaccine is less immunogenic than the conjugate\nvaccine and also induces a hyporesponsive state that persists for at least\n12 months.},\n\tnumber = {19},\n\turldate = {2014-08-24},\n\tjournal = {JAMA},\n\tauthor = {{MacDonald NE} and {Halperin SA} and {Law BJ} and {Forrest B} and {Danzig LE} and {Granoff DM}},\n\tmonth = nov,\n\tyear = {1998},\n\tpages = {1685--1689},\n}\n\n","author_short":["MacDonald NE","Halperin SA","Law BJ","Forrest B","Danzig LE","Granoff DM"],"key":"macdonald_ne_induction_1998","id":"macdonald_ne_induction_1998","bibbaseid":"macdonaldne-halperinsa-lawbj-forrestb-danzigle-granoffdm-inductionofimmunologicmemorybyconjugatedvsplainmeningococcalcpolysaccharidevaccineintoddlersarandomizedcontrolledtrial-1998","role":"author","urls":{"Paper":"http://dx.doi.org/10.1001/jama.280.19.1685"},"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://bibbase.org/zotero/robin.marlow","dataSources":["ix72eqAAMGCuupBaz"],"keywords":[],"search_terms":["induction","immunologic","memory","conjugated","plain","meningococcal","polysaccharide","vaccine","toddlers","randomized","controlled","trial","macdonald ne","halperin sa","law bj","forrest b","danzig le","granoff dm"],"title":"Induction of immunologic memory by conjugated vs plain meningococcal c polysaccharide vaccine in toddlers: A randomized controlled trial","year":1998}