@article{
 title = {Total synthesis of rapamycin},
 type = {article},
 year = {2007},
 keywords = {Antitumor agents,Immunosuppressants,Macrocyclization,Natural products,Total synthesis},
 pages = {591-597},
 volume = {46},
 websites = {http://onlinelibrary.wiley.com/store/10.1002/anie.200604053/asset/591_ftp.pdf?v=1&t=h66fyv71&s=5d3b06cd57d32b388476999713af947cac841de8},
 publisher = {Wiley-VCH Verlag GmbH & Co. KGaA},
 id = {4a37ee91-9505-3c0e-af07-402761fdbda4},
 created = {2015-10-07T14:20:51.000Z},
 file_attached = {true},
 profile_id = {64f7fb50-d000-335d-a02d-06c5f340a97a},
 last_modified = {2018-09-03T10:20:45.843Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 citation_key = {Maddess2007},
 source_type = {Journal Article},
 notes = {<b>From Duplicate 2 (<i>Total synthesis of rapamycin</i> - Maddess, Matthew L; Tackett, Miles N; Watanabe, Hidenori; Brennan, Paul E; Spilling, Christopher D; Scott, James S; Osborn, David P; Ley, Steven V)<br/></b><br/>CAPLUS AN 2007:103751(Journal)},
 private_publication = {false},
 abstract = {For over 30 years, rapamycin has generated a sustained and intense interest from the scientific community as a result of its exceptional pharmacological properties and challenging structural features. In addition to its well known therapeutic value as a potent immunosuppressive agent, rapamycin and its derivatives have recently gained prominence for the treatment of a wide variety of other human malignancies. Herein we disclose full details of our extensive investigation into the synthesis of rapamycin that culminated in a new and convergent preparation featuring a macro-etherification/catechol-templating strategy for construction of the macrocyclic core of this natural product.},
 bibtype = {article},
 author = {Maddess, Matthew L. and Tackett, Miles N. and Watanabe, Hidenori and Brennan, Paul E. and Spilling, Christopher D. and Scott, James S. and Osborn, David P. and Ley, Steven V.},
 doi = {10.1002/anie.200604053},
 journal = {Angewandte Chemie - International Edition},
 number = {4}
}

{"_id":"o3wJoHxLettYQjFCk","bibbaseid":"maddess-tackett-watanabe-brennan-spilling-scott-osborn-ley-totalsynthesisofrapamycin-2007","downloads":1,"creationDate":"2018-08-31T13:28:42.343Z","title":"Total synthesis of rapamycin","author_short":["Maddess, M., L.","Tackett, M., N.","Watanabe, H.","Brennan, P., E.","Spilling, C., D.","Scott, J., S.","Osborn, D., P.","Ley, S., V."],"year":2007,"bibtype":"article","biburl":"https://bibbase.org/service/mendeley/64f7fb50-d000-335d-a02d-06c5f340a97a","bibdata":{"title":"Total synthesis of rapamycin","type":"article","year":"2007","keywords":"Antitumor agents,Immunosuppressants,Macrocyclization,Natural products,Total synthesis","pages":"591-597","volume":"46","websites":"http://onlinelibrary.wiley.com/store/10.1002/anie.200604053/asset/591_ftp.pdf?v=1&t=h66fyv71&s=5d3b06cd57d32b388476999713af947cac841de8","publisher":"Wiley-VCH Verlag GmbH & Co. KGaA","id":"4a37ee91-9505-3c0e-af07-402761fdbda4","created":"2015-10-07T14:20:51.000Z","file_attached":"true","profile_id":"64f7fb50-d000-335d-a02d-06c5f340a97a","last_modified":"2018-09-03T10:20:45.843Z","read":false,"starred":false,"authored":"true","confirmed":"true","hidden":false,"citation_key":"Maddess2007","source_type":"Journal Article","notes":"<b>From Duplicate 2 (<i>Total synthesis of rapamycin</i> - Maddess, Matthew L; Tackett, Miles N; Watanabe, Hidenori; Brennan, Paul E; Spilling, Christopher D; Scott, James S; Osborn, David P; Ley, Steven V)<br/></b><br/>CAPLUS AN 2007:103751(Journal)","private_publication":false,"abstract":"For over 30 years, rapamycin has generated a sustained and intense interest from the scientific community as a result of its exceptional pharmacological properties and challenging structural features. In addition to its well known therapeutic value as a potent immunosuppressive agent, rapamycin and its derivatives have recently gained prominence for the treatment of a wide variety of other human malignancies. Herein we disclose full details of our extensive investigation into the synthesis of rapamycin that culminated in a new and convergent preparation featuring a macro-etherification/catechol-templating strategy for construction of the macrocyclic core of this natural product.","bibtype":"article","author":"Maddess, Matthew L. and Tackett, Miles N. and Watanabe, Hidenori and Brennan, Paul E. and Spilling, Christopher D. and Scott, James S. and Osborn, David P. and Ley, Steven V.","doi":"10.1002/anie.200604053","journal":"Angewandte Chemie - International Edition","number":"4","bibtex":"@article{\n title = {Total synthesis of rapamycin},\n type = {article},\n year = {2007},\n keywords = {Antitumor agents,Immunosuppressants,Macrocyclization,Natural products,Total synthesis},\n pages = {591-597},\n volume = {46},\n websites = {http://onlinelibrary.wiley.com/store/10.1002/anie.200604053/asset/591_ftp.pdf?v=1&t=h66fyv71&s=5d3b06cd57d32b388476999713af947cac841de8},\n publisher = {Wiley-VCH Verlag GmbH & Co. KGaA},\n id = {4a37ee91-9505-3c0e-af07-402761fdbda4},\n created = {2015-10-07T14:20:51.000Z},\n file_attached = {true},\n profile_id = {64f7fb50-d000-335d-a02d-06c5f340a97a},\n last_modified = {2018-09-03T10:20:45.843Z},\n read = {false},\n starred = {false},\n authored = {true},\n confirmed = {true},\n hidden = {false},\n citation_key = {Maddess2007},\n source_type = {Journal Article},\n notes = {<b>From Duplicate 2 (<i>Total synthesis of rapamycin</i> - Maddess, Matthew L; Tackett, Miles N; Watanabe, Hidenori; Brennan, Paul E; Spilling, Christopher D; Scott, James S; Osborn, David P; Ley, Steven V)<br/></b><br/>CAPLUS AN 2007:103751(Journal)},\n private_publication = {false},\n abstract = {For over 30 years, rapamycin has generated a sustained and intense interest from the scientific community as a result of its exceptional pharmacological properties and challenging structural features. In addition to its well known therapeutic value as a potent immunosuppressive agent, rapamycin and its derivatives have recently gained prominence for the treatment of a wide variety of other human malignancies. Herein we disclose full details of our extensive investigation into the synthesis of rapamycin that culminated in a new and convergent preparation featuring a macro-etherification/catechol-templating strategy for construction of the macrocyclic core of this natural product.},\n bibtype = {article},\n author = {Maddess, Matthew L. and Tackett, Miles N. and Watanabe, Hidenori and Brennan, Paul E. and Spilling, Christopher D. and Scott, James S. and Osborn, David P. and Ley, Steven V.},\n doi = {10.1002/anie.200604053},\n journal = {Angewandte Chemie - International Edition},\n number = {4}\n}","author_short":["Maddess, M., L.","Tackett, M., N.","Watanabe, H.","Brennan, P., E.","Spilling, C., D.","Scott, J., S.","Osborn, D., P.","Ley, S., V."],"urls":{"Paper":"https://bibbase.org/service/mendeley/64f7fb50-d000-335d-a02d-06c5f340a97a/file/5a61fdc9-416f-f0d7-5161-35631aef890b/2007-Total_synthesis_of_rapamycin.pdf.pdf","Website":"http://onlinelibrary.wiley.com/store/10.1002/anie.200604053/asset/591_ftp.pdf?v=1&t=h66fyv71&s=5d3b06cd57d32b388476999713af947cac841de8"},"biburl":"https://bibbase.org/service/mendeley/64f7fb50-d000-335d-a02d-06c5f340a97a","bibbaseid":"maddess-tackett-watanabe-brennan-spilling-scott-osborn-ley-totalsynthesisofrapamycin-2007","role":"author","keyword":["Antitumor agents","Immunosuppressants","Macrocyclization","Natural products","Total synthesis"],"metadata":{"authorlinks":{"brennan, p":"https://www.brennanresearchgroup.com/publications"}},"downloads":1},"search_terms":["total","synthesis","rapamycin","maddess","tackett","watanabe","brennan","spilling","scott","osborn","ley"],"keywords":["antitumor agents","immunosuppressants","macrocyclization","natural products","total synthesis"],"authorIDs":["2PcjuiF3R7eQubzsS","3Wg6Evy8g6dGhA6RP","5b8cf59e29c69a10000000dd","5b8d0d2b29c69a1000000190","5df615c32b34d0de01000067","5e04257fc51eb3de0100004e","5e074383513c7fdf010000b2","5e0d5e8c24d7cbdf0100005a","5e0fad9cf350a2de01000048","5e14621a0467fede01000037","5e161098f67f7dde01000315","5e1c57dee556c6de01000117","5e1e05302cced5de010001fe","5e1edaa3875c69df01000096","5e286db66ae365de0100012e","5e29b862edf563df010000d2","5e30592357a222df01000189","5e31a6726be690de01000130","5e35c99476dd53de0100003e","5e367c8ef0f9c4de01000058","5e37e643e8908edf010000a5","5e3bd1e704fc23e401000022","5e3c19530c5519de010000eb","5e3e45f7018e1dde01000045","5e452d19605639de0100005a","5e45df30ad0603df01000105","5e46b09f8573d1de01000014","5e4c15c92dc400de01000056","5e4c21a52dc400de0100018a","5e4c2a582dc400de01000297","5e4c4ea8271596df01000048","5e4c706ef2c6ddde010000dd","5e4eb86dd9cddadf0100003c","5e4f7b5a42a908de0100000c","5e540863e81566de010000ef","5e55ee11c2c8a2df010000bb","5e5bf6d1d49321e0010000b2","5e5d6754ad47bcde01000154","5e5f76a55766d9df010000b8","5e5fae7919c3fade0100013b","5e6606d7fa8a45de01000074","5vpfcTcw8zWCJD2nF","6FKA7EN4QuMHpmwi6","An3w7fKehnECWntHD","Bu2c3DHDtJvHTYMHq","BznF7qjM756E4jqnf","DfC2nWXrsDiWAGdeK","EuWxtQZ8J6tPrKcHJ","F99s5PmgDMnmZMCrf","GWEtQQ7DK3eqH6BKs","KoTB5Qe3rxh4268Ks","LTPygeEwWdFJYM3ex","MqNwdFkRBormaL3gc","PhPZA8Ev3s7adKhQp","Sx9chhPN3Rv7ceC2x","TEr37QWFQEKfekGBX","b8tt4q6azbrxnRfyb","cjsLZWYTgsqhBfmh8","cttrvqjxXS3rH8Dse","dkaRruzTHGciJqey5","ewh6B4GHpYJvXWBFu","g4JkphGbeNea298iY","iSo57iyxSkCmqqcdD","n9wv3r7bpGdLhh2Gf","tDAsqmS4FrzLst3z7","x3SHcLfxXH8uRbJbK"],"dataSources":["Pa586au6MYhHM9r97","ya2CyA73rpZseyrZ8","2252seNhipfTmjEBQ"]}