@article{Madhietal2021,
abstract = {A double-blind randomized trial in South Africa documented poor efficacy of two doses of the ChAdOx1 nCoV-19 vaccine against the B.1.351 variant of SARS-CoV-2 that emerged in South Africa. Infections occurred in 3.2\% of placebo recipients and in 2.5\% of vaccine recipients. Thirty-nine of the 42 virus isolates were the B.1.351 variant. None of the cases led to hospitalization or death.},
author = {Madhi, Shabir A and Baillie, Vicky and Cutland, Clare L and Voysey, Merryn and Koen, Anthonet L and Fairlie, Lee and Padayachee, Sherman D and Dheda, Keertan and Barnabas, Shaun L and Bhorat, Qasim E and Briner, Carmen and Kwatra, Gaurav and Ahmed, Khatija and Aley, Parvinder and Bhikha, Sutika and Bhiman, Jinal N and Bhorat, As’ad E and du Plessis, Jeanine and Esmail, Aliasgar and Groenewald, Marisa and Horne, Elizea and Hwa, Shi-Hsia and Jose, Aylin and Lambe, Teresa and Laubscher, Matt and Malahleha, Mookho and Masenya, Masebole and Masilela, Mduduzi and McKenzie, Shakeel and Molapo, Kgaogelo and Moultrie, Andrew and Oelofse, Suzette and Patel, Faeezah and Pillay, Sureshnee and Rhead, Sarah and Rodel, Hylton and Rossouw, Lindie and Taoushanis, Carol and Tegally, Houriiyah and Thombrayil, Asha and van Eck, Samuel and Wibmer, Constantinos K and Durham, Nicholas M and Kelly, Elizabeth J and Villafana, Tonya L and Gilbert, Sarah and Pollard, Andrew J and de Oliveira, Tulio and Moore, Penny L and Sigal, Alex and Izu, Alane},
address = {United States},
copyright = {Copyright © 2021 Massachusetts Medical Society. All rights reserved.},
issn = {0028-4793},
journal = {The New England journal of medicine},
keywords = {Adenoviridae ; Adolescent ; Adult ; Adverse events ; Antibodies ; Antibodies, Neutralizing - blood ; Antibodies, Neutralizing - physiology ; ChAdOx1 nCoV-19 ; Clinical trials ; Coronaviruses ; COVID-19 ; COVID-19 - epidemiology ; COVID-19 - immunology ; COVID-19 - prevention & control ; COVID-19 Serological Testing ; COVID-19 vaccines ; COVID-19 Vaccines - administration & dosage ; COVID-19 Vaccines - adverse effects ; COVID-19 Vaccines - immunology ; Disease resistance ; Double-Blind Method ; Genomes ; HIV ; Human immunodeficiency virus ; Humans ; Immunogenicity, Vaccine ; Infections ; Laboratories ; Medical research ; Medicine, Experimental ; Middle Aged ; Mutation ; Original ; Placebos ; Safety ; SARS-CoV-2 ; Severe acute respiratory syndrome coronavirus 2 ; Sodium chloride ; South Africa ; T-Lymphocytes - physiology ; Treatment Failure ; Vaccine efficacy ; Vaccine Potency ; Vaccines ; Viruses ; Young Adult},
language = {eng},
number = {20},
organization = {Wits-VIDA COVID Group},
pages = {1885-1898},
publisher = {Massachusetts Medical Society},
title = {Efficacy of the {ChAdOx1 nCoV-19 Covid-19} Vaccine against the {B.1.351} Variant},
volume = {384},
year = {2021},
}

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None of the cases led to hospitalization or death.","author":[{"propositions":[],"lastnames":["Madhi"],"firstnames":["Shabir","A"],"suffixes":[]},{"propositions":[],"lastnames":["Baillie"],"firstnames":["Vicky"],"suffixes":[]},{"propositions":[],"lastnames":["Cutland"],"firstnames":["Clare","L"],"suffixes":[]},{"propositions":[],"lastnames":["Voysey"],"firstnames":["Merryn"],"suffixes":[]},{"propositions":[],"lastnames":["Koen"],"firstnames":["Anthonet","L"],"suffixes":[]},{"propositions":[],"lastnames":["Fairlie"],"firstnames":["Lee"],"suffixes":[]},{"propositions":[],"lastnames":["Padayachee"],"firstnames":["Sherman","D"],"suffixes":[]},{"propositions":[],"lastnames":["Dheda"],"firstnames":["Keertan"],"suffixes":[]},{"propositions":[],"lastnames":["Barnabas"],"firstnames":["Shaun","L"],"suffixes":[]},{"propositions":[],"lastnames":["Bhorat"],"firstnames":["Qasim","E"],"suffixes":[]},{"propositions":[],"lastnames":["Briner"],"firstnames":["Carmen"],"suffixes":[]},{"propositions":[],"lastnames":["Kwatra"],"firstnames":["Gaurav"],"suffixes":[]},{"propositions":[],"lastnames":["Ahmed"],"firstnames":["Khatija"],"suffixes":[]},{"propositions":[],"lastnames":["Aley"],"firstnames":["Parvinder"],"suffixes":[]},{"propositions":[],"lastnames":["Bhikha"],"firstnames":["Sutika"],"suffixes":[]},{"propositions":[],"lastnames":["Bhiman"],"firstnames":["Jinal","N"],"suffixes":[]},{"propositions":[],"lastnames":["Bhorat"],"firstnames":["As’ad","E"],"suffixes":[]},{"propositions":["du"],"lastnames":["Plessis"],"firstnames":["Jeanine"],"suffixes":[]},{"propositions":[],"lastnames":["Esmail"],"firstnames":["Aliasgar"],"suffixes":[]},{"propositions":[],"lastnames":["Groenewald"],"firstnames":["Marisa"],"suffixes":[]},{"propositions":[],"lastnames":["Horne"],"firstnames":["Elizea"],"suffixes":[]},{"propositions":[],"lastnames":["Hwa"],"firstnames":["Shi-Hsia"],"suffixes":[]},{"propositions":[],"lastnames":["Jose"],"firstnames":["Aylin"],"suffixes":[]},{"propositions":[],"lastnames":["Lambe"],"firstnames":["Teresa"],"suffixes":[]},{"propositions":[],"lastnames":["Laubscher"],"firstnames":["Matt"],"suffixes":[]},{"propositions":[],"lastnames":["Malahleha"],"firstnames":["Mookho"],"suffixes":[]},{"propositions":[],"lastnames":["Masenya"],"firstnames":["Masebole"],"suffixes":[]},{"propositions":[],"lastnames":["Masilela"],"firstnames":["Mduduzi"],"suffixes":[]},{"propositions":[],"lastnames":["McKenzie"],"firstnames":["Shakeel"],"suffixes":[]},{"propositions":[],"lastnames":["Molapo"],"firstnames":["Kgaogelo"],"suffixes":[]},{"propositions":[],"lastnames":["Moultrie"],"firstnames":["Andrew"],"suffixes":[]},{"propositions":[],"lastnames":["Oelofse"],"firstnames":["Suzette"],"suffixes":[]},{"propositions":[],"lastnames":["Patel"],"firstnames":["Faeezah"],"suffixes":[]},{"propositions":[],"lastnames":["Pillay"],"firstnames":["Sureshnee"],"suffixes":[]},{"propositions":[],"lastnames":["Rhead"],"firstnames":["Sarah"],"suffixes":[]},{"propositions":[],"lastnames":["Rodel"],"firstnames":["Hylton"],"suffixes":[]},{"propositions":[],"lastnames":["Rossouw"],"firstnames":["Lindie"],"suffixes":[]},{"propositions":[],"lastnames":["Taoushanis"],"firstnames":["Carol"],"suffixes":[]},{"propositions":[],"lastnames":["Tegally"],"firstnames":["Houriiyah"],"suffixes":[]},{"propositions":[],"lastnames":["Thombrayil"],"firstnames":["Asha"],"suffixes":[]},{"propositions":["van"],"lastnames":["Eck"],"firstnames":["Samuel"],"suffixes":[]},{"propositions":[],"lastnames":["Wibmer"],"firstnames":["Constantinos","K"],"suffixes":[]},{"propositions":[],"lastnames":["Durham"],"firstnames":["Nicholas","M"],"suffixes":[]},{"propositions":[],"lastnames":["Kelly"],"firstnames":["Elizabeth","J"],"suffixes":[]},{"propositions":[],"lastnames":["Villafana"],"firstnames":["Tonya","L"],"suffixes":[]},{"propositions":[],"lastnames":["Gilbert"],"firstnames":["Sarah"],"suffixes":[]},{"propositions":[],"lastnames":["Pollard"],"firstnames":["Andrew","J"],"suffixes":[]},{"propositions":["de"],"lastnames":["Oliveira"],"firstnames":["Tulio"],"suffixes":[]},{"propositions":[],"lastnames":["Moore"],"firstnames":["Penny","L"],"suffixes":[]},{"propositions":[],"lastnames":["Sigal"],"firstnames":["Alex"],"suffixes":[]},{"propositions":[],"lastnames":["Izu"],"firstnames":["Alane"],"suffixes":[]}],"address":"United States","copyright":"Copyright © 2021 Massachusetts Medical Society. All rights reserved.","issn":"0028-4793","journal":"The New England journal of medicine","keywords":"Adenoviridae ; Adolescent ; Adult ; Adverse events ; Antibodies ; Antibodies, Neutralizing - blood ; Antibodies, Neutralizing - physiology ; ChAdOx1 nCoV-19 ; Clinical trials ; Coronaviruses ; COVID-19 ; COVID-19 - epidemiology ; COVID-19 - immunology ; COVID-19 - prevention & control ; COVID-19 Serological Testing ; COVID-19 vaccines ; COVID-19 Vaccines - administration & dosage ; COVID-19 Vaccines - adverse effects ; COVID-19 Vaccines - immunology ; Disease resistance ; Double-Blind Method ; Genomes ; HIV ; Human immunodeficiency virus ; Humans ; Immunogenicity, Vaccine ; Infections ; Laboratories ; Medical research ; Medicine, Experimental ; Middle Aged ; Mutation ; Original ; Placebos ; Safety ; SARS-CoV-2 ; Severe acute respiratory syndrome coronavirus 2 ; Sodium chloride ; South Africa ; T-Lymphocytes - physiology ; Treatment Failure ; Vaccine efficacy ; Vaccine Potency ; Vaccines ; Viruses ; Young Adult","language":"eng","number":"20","organization":"Wits-VIDA COVID Group","pages":"1885-1898","publisher":"Massachusetts Medical Society","title":"Efficacy of the ChAdOx1 nCoV-19 Covid-19 Vaccine against the B.1.351 Variant","volume":"384","year":"2021","bibtex":"@article{Madhietal2021,\nabstract = {A double-blind randomized trial in South Africa documented poor efficacy of two doses of the ChAdOx1 nCoV-19 vaccine against the B.1.351 variant of SARS-CoV-2 that emerged in South Africa. Infections occurred in 3.2\\% of placebo recipients and in 2.5\\% of vaccine recipients. Thirty-nine of the 42 virus isolates were the B.1.351 variant. None of the cases led to hospitalization or death.},\nauthor = {Madhi, Shabir A and Baillie, Vicky and Cutland, Clare L and Voysey, Merryn and Koen, Anthonet L and Fairlie, Lee and Padayachee, Sherman D and Dheda, Keertan and Barnabas, Shaun L and Bhorat, Qasim E and Briner, Carmen and Kwatra, Gaurav and Ahmed, Khatija and Aley, Parvinder and Bhikha, Sutika and Bhiman, Jinal N and Bhorat, As’ad E and du Plessis, Jeanine and Esmail, Aliasgar and Groenewald, Marisa and Horne, Elizea and Hwa, Shi-Hsia and Jose, Aylin and Lambe, Teresa and Laubscher, Matt and Malahleha, Mookho and Masenya, Masebole and Masilela, Mduduzi and McKenzie, Shakeel and Molapo, Kgaogelo and Moultrie, Andrew and Oelofse, Suzette and Patel, Faeezah and Pillay, Sureshnee and Rhead, Sarah and Rodel, Hylton and Rossouw, Lindie and Taoushanis, Carol and Tegally, Houriiyah and Thombrayil, Asha and van Eck, Samuel and Wibmer, Constantinos K and Durham, Nicholas M and Kelly, Elizabeth J and Villafana, Tonya L and Gilbert, Sarah and Pollard, Andrew J and de Oliveira, Tulio and Moore, Penny L and Sigal, Alex and Izu, Alane},\naddress = {United States},\ncopyright = {Copyright © 2021 Massachusetts Medical Society. All rights reserved.},\nissn = {0028-4793},\njournal = {The New England journal of medicine},\nkeywords = {Adenoviridae ; Adolescent ; Adult ; Adverse events ; Antibodies ; Antibodies, Neutralizing - blood ; Antibodies, Neutralizing - physiology ; ChAdOx1 nCoV-19 ; Clinical trials ; Coronaviruses ; COVID-19 ; COVID-19 - epidemiology ; COVID-19 - immunology ; COVID-19 - prevention & control ; COVID-19 Serological Testing ; COVID-19 vaccines ; COVID-19 Vaccines - administration & dosage ; COVID-19 Vaccines - adverse effects ; COVID-19 Vaccines - immunology ; Disease resistance ; Double-Blind Method ; Genomes ; HIV ; Human immunodeficiency virus ; Humans ; Immunogenicity, Vaccine ; Infections ; Laboratories ; Medical research ; Medicine, Experimental ; Middle Aged ; Mutation ; Original ; Placebos ; Safety ; SARS-CoV-2 ; Severe acute respiratory syndrome coronavirus 2 ; Sodium chloride ; South Africa ; T-Lymphocytes - physiology ; Treatment Failure ; Vaccine efficacy ; Vaccine Potency ; Vaccines ; Viruses ; Young Adult},\nlanguage = {eng},\nnumber = {20},\norganization = {Wits-VIDA COVID Group},\npages = {1885-1898},\npublisher = {Massachusetts Medical Society},\ntitle = {Efficacy of the {ChAdOx1 nCoV-19 Covid-19} Vaccine against the {B.1.351} Variant},\nvolume = {384},\nyear = {2021},\n}\n\n","author_short":["Madhi, S. 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