@misc{madjid_a.s._thoracic_2008,
	title = {Thoracic epidural anesthesia attenuates hemorrhagic-induced splanchnic hypo-perfusion in post-resuscitation experimental hemorrhagic shock},
	url = {http://mji.ui.ac.id/journal/index.php/mji/article/download/304/299},
	abstract = {The purpose of present study was to assess the effects of thoracic epidural anesthesia on splanchnic perfusion, bacterial translocation and histopathologic changes in experimental hemorrhagic shock in short-tailed macaques (Macaca nemestrina). Sixteen Macaca nemestrinas were randomly assigned to one of two groups i.e. the lidocaine group (n = 8), receiving general anesthesia plus lidocaine thoracic epidural anesthesia; and the saline group (n = 8), receiving general anesthesia alone as control. Hemorrhagic shock was induced by withdrawing blood gradually to a mean arterial pressure (MAP) of 40 mm Hg, and maintained for 60 minutes. Animals were then resuscitated with their own blood and ringer lactate solution (RL). After resuscitation, epidural lidocaine 2\% was given in the lidocaine group and saline in the control group. Resuscitation that was performed after one hour hemorrhagic shock, with hemodynamic variables and urine output returned to normal, revealed there was no improvement of splanchnic perfusion. PgCO2, P(g-a)CO2, and pHi remained in critical value and tended to deteriorate in the saline group. Contrast to saline group, splanchnic perfusion in lidocaine group tended to improve. This condition was supported by the finding of less bacterial translocation and better histopathologic changes in lidocaine thoracic epidural anesthesia group than in saline group. This study concludes that lidocaine thoracic epidural anesthesia attenuates splachnic hypoperfusion in post-resuscitation hemorrhagic shock in Macaca nemestrina. Copyright © 2008, Faculty of Medicine, Universitas Indonesia. All rights reserved.},
	journal = {Medical Journal of Indonesia},
	author = {{Madjid A.S.}},
	year = {2008},
	keywords = {*bacterial translocation, *experimental hemorrhagic shock, *experimental hemorrhagic shock/dt [Drug Therapy], *lidocaine, *perfusion, *resuscitation, *splanchnic nerve, *thorax epidural anesthesia, Escherichia coli, Lactococcus garvieae, Macaca nemestrina, Pseudomonas aeruginosa, Ringer lactate solution, Serratia, acid base balance, adolescent, adult, alpha hemolytic Streptococcus, animal experiment, animal model, animal tissue, article, carbon dioxide, central venous pressure, control group, controlled study, critical value, diuresis, drug withdrawal, epidural anesthesia, experimental hemorrhagic shock/dt [Drug Therapy], fluoroscopy, gastric pH monitoring, general anesthesia, heart index, hemodynamics, histopathology, ketamine/cm [Drug Comparison], ketamine/dt [Drug Therapy], lactate blood level, lidocaine/cm [Drug Comparison], lidocaine/dt [Drug Therapy], mean arterial pressure, nonhuman, sodium chloride, sodium chloride/cm [Drug Comparison], sodium chloride/dt [Drug Therapy], urine volume}
}

{"_id":"qahB9jnhLfHPRbysr","bibbaseid":"madjidas-thoracicepiduralanesthesiaattenuateshemorrhagicinducedsplanchnichypoperfusioninpostresuscitationexperimentalhemorrhagicshock-2008","downloads":0,"creationDate":"2017-05-12T20:20:57.722Z","title":"Thoracic epidural anesthesia attenuates hemorrhagic-induced splanchnic hypo-perfusion in post-resuscitation experimental hemorrhagic shock","author_short":["Madjid A.S."],"year":2008,"bibtype":"misc","biburl":"http://bibbase.org/zotero/gxu917","bibdata":{"bibtype":"misc","type":"misc","title":"Thoracic epidural anesthesia attenuates hemorrhagic-induced splanchnic hypo-perfusion in post-resuscitation experimental hemorrhagic shock","url":"http://mji.ui.ac.id/journal/index.php/mji/article/download/304/299","abstract":"The purpose of present study was to assess the effects of thoracic epidural anesthesia on splanchnic perfusion, bacterial translocation and histopathologic changes in experimental hemorrhagic shock in short-tailed macaques (Macaca nemestrina). Sixteen Macaca nemestrinas were randomly assigned to one of two groups i.e. the lidocaine group (n = 8), receiving general anesthesia plus lidocaine thoracic epidural anesthesia; and the saline group (n = 8), receiving general anesthesia alone as control. Hemorrhagic shock was induced by withdrawing blood gradually to a mean arterial pressure (MAP) of 40 mm Hg, and maintained for 60 minutes. Animals were then resuscitated with their own blood and ringer lactate solution (RL). After resuscitation, epidural lidocaine 2% was given in the lidocaine group and saline in the control group. Resuscitation that was performed after one hour hemorrhagic shock, with hemodynamic variables and urine output returned to normal, revealed there was no improvement of splanchnic perfusion. PgCO2, P(g-a)CO2, and pHi remained in critical value and tended to deteriorate in the saline group. Contrast to saline group, splanchnic perfusion in lidocaine group tended to improve. This condition was supported by the finding of less bacterial translocation and better histopathologic changes in lidocaine thoracic epidural anesthesia group than in saline group. This study concludes that lidocaine thoracic epidural anesthesia attenuates splachnic hypoperfusion in post-resuscitation hemorrhagic shock in Macaca nemestrina. Copyright © 2008, Faculty of Medicine, Universitas Indonesia. All rights reserved.","journal":"Medical Journal of Indonesia","author":[{"firstnames":[],"propositions":[],"lastnames":["Madjid A.S."],"suffixes":[]}],"year":"2008","keywords":"*bacterial translocation, *experimental hemorrhagic shock, *experimental hemorrhagic shock/dt [Drug Therapy], *lidocaine, *perfusion, *resuscitation, *splanchnic nerve, *thorax epidural anesthesia, Escherichia coli, Lactococcus garvieae, Macaca nemestrina, Pseudomonas aeruginosa, Ringer lactate solution, Serratia, acid base balance, adolescent, adult, alpha hemolytic Streptococcus, animal experiment, animal model, animal tissue, article, carbon dioxide, central venous pressure, control group, controlled study, critical value, diuresis, drug withdrawal, epidural anesthesia, experimental hemorrhagic shock/dt [Drug Therapy], fluoroscopy, gastric pH monitoring, general anesthesia, heart index, hemodynamics, histopathology, ketamine/cm [Drug Comparison], ketamine/dt [Drug Therapy], lactate blood level, lidocaine/cm [Drug Comparison], lidocaine/dt [Drug Therapy], mean arterial pressure, nonhuman, sodium chloride, sodium chloride/cm [Drug Comparison], sodium chloride/dt [Drug Therapy], urine volume","bibtex":"@misc{madjid_a.s._thoracic_2008,\n\ttitle = {Thoracic epidural anesthesia attenuates hemorrhagic-induced splanchnic hypo-perfusion in post-resuscitation experimental hemorrhagic shock},\n\turl = {http://mji.ui.ac.id/journal/index.php/mji/article/download/304/299},\n\tabstract = {The purpose of present study was to assess the effects of thoracic epidural anesthesia on splanchnic perfusion, bacterial translocation and histopathologic changes in experimental hemorrhagic shock in short-tailed macaques (Macaca nemestrina). Sixteen Macaca nemestrinas were randomly assigned to one of two groups i.e. the lidocaine group (n = 8), receiving general anesthesia plus lidocaine thoracic epidural anesthesia; and the saline group (n = 8), receiving general anesthesia alone as control. Hemorrhagic shock was induced by withdrawing blood gradually to a mean arterial pressure (MAP) of 40 mm Hg, and maintained for 60 minutes. Animals were then resuscitated with their own blood and ringer lactate solution (RL). After resuscitation, epidural lidocaine 2\\% was given in the lidocaine group and saline in the control group. Resuscitation that was performed after one hour hemorrhagic shock, with hemodynamic variables and urine output returned to normal, revealed there was no improvement of splanchnic perfusion. PgCO2, P(g-a)CO2, and pHi remained in critical value and tended to deteriorate in the saline group. Contrast to saline group, splanchnic perfusion in lidocaine group tended to improve. This condition was supported by the finding of less bacterial translocation and better histopathologic changes in lidocaine thoracic epidural anesthesia group than in saline group. This study concludes that lidocaine thoracic epidural anesthesia attenuates splachnic hypoperfusion in post-resuscitation hemorrhagic shock in Macaca nemestrina. Copyright © 2008, Faculty of Medicine, Universitas Indonesia. All rights reserved.},\n\tjournal = {Medical Journal of Indonesia},\n\tauthor = {{Madjid A.S.}},\n\tyear = {2008},\n\tkeywords = {*bacterial translocation, *experimental hemorrhagic shock, *experimental hemorrhagic shock/dt [Drug Therapy], *lidocaine, *perfusion, *resuscitation, *splanchnic nerve, *thorax epidural anesthesia, Escherichia coli, Lactococcus garvieae, Macaca nemestrina, Pseudomonas aeruginosa, Ringer lactate solution, Serratia, acid base balance, adolescent, adult, alpha hemolytic Streptococcus, animal experiment, animal model, animal tissue, article, carbon dioxide, central venous pressure, control group, controlled study, critical value, diuresis, drug withdrawal, epidural anesthesia, experimental hemorrhagic shock/dt [Drug Therapy], fluoroscopy, gastric pH monitoring, general anesthesia, heart index, hemodynamics, histopathology, ketamine/cm [Drug Comparison], ketamine/dt [Drug Therapy], lactate blood level, lidocaine/cm [Drug Comparison], lidocaine/dt [Drug Therapy], mean arterial pressure, nonhuman, sodium chloride, sodium chloride/cm [Drug Comparison], sodium chloride/dt [Drug Therapy], urine volume}\n}\n\n","author_short":["Madjid A.S."],"key":"madjid_a.s._thoracic_2008","id":"madjid_a.s._thoracic_2008","bibbaseid":"madjidas-thoracicepiduralanesthesiaattenuateshemorrhagicinducedsplanchnichypoperfusioninpostresuscitationexperimentalhemorrhagicshock-2008","role":"author","urls":{"Paper":"http://mji.ui.ac.id/journal/index.php/mji/article/download/304/299"},"keyword":["*bacterial translocation","*experimental hemorrhagic shock","*experimental hemorrhagic shock/dt [Drug Therapy]","*lidocaine","*perfusion","*resuscitation","*splanchnic nerve","*thorax epidural anesthesia","Escherichia coli","Lactococcus garvieae","Macaca nemestrina","Pseudomonas aeruginosa","Ringer lactate solution","Serratia","acid base balance","adolescent","adult","alpha hemolytic Streptococcus","animal experiment","animal model","animal tissue","article","carbon dioxide","central venous pressure","control group","controlled study","critical value","diuresis","drug withdrawal","epidural anesthesia","experimental hemorrhagic shock/dt [Drug Therapy]","fluoroscopy","gastric pH monitoring","general anesthesia","heart index","hemodynamics","histopathology","ketamine/cm [Drug Comparison]","ketamine/dt [Drug Therapy]","lactate blood level","lidocaine/cm [Drug Comparison]","lidocaine/dt [Drug Therapy]","mean arterial pressure","nonhuman","sodium chloride","sodium chloride/cm [Drug Comparison]","sodium chloride/dt [Drug Therapy]","urine volume"],"downloads":0,"html":""},"search_terms":["thoracic","epidural","anesthesia","attenuates","hemorrhagic","induced","splanchnic","hypo","perfusion","post","resuscitation","experimental","hemorrhagic","shock","madjid a.s."],"keywords":["*bacterial translocation","*experimental hemorrhagic shock","*experimental hemorrhagic shock/dt [drug therapy]","*lidocaine","*perfusion","*resuscitation","*splanchnic nerve","*thorax epidural anesthesia","escherichia coli","lactococcus garvieae","macaca nemestrina","pseudomonas aeruginosa","ringer lactate solution","serratia","acid base balance","adolescent","adult","alpha hemolytic streptococcus","animal experiment","animal model","animal tissue","article","carbon dioxide","central venous pressure","control group","controlled study","critical value","diuresis","drug withdrawal","epidural anesthesia","experimental hemorrhagic shock/dt [drug therapy]","fluoroscopy","gastric ph monitoring","general anesthesia","heart index","hemodynamics","histopathology","ketamine/cm [drug comparison]","ketamine/dt [drug therapy]","lactate blood level","lidocaine/cm [drug comparison]","lidocaine/dt [drug therapy]","mean arterial pressure","nonhuman","sodium chloride","sodium chloride/cm [drug comparison]","sodium chloride/dt [drug therapy]","urine volume"],"authorIDs":[],"dataSources":["9LqPNaySNpNxYBFzj"]}