Genetic factors contribute more to hip than knee surgery due to osteoarthritis - A population-based twin registry study of joint arthroplasty. Magnusson, K., Scurrah, K., Ystrom, E., Ørstavik, R. E., Nilsen, T., Steingrímsdóttir, Ó A., Ferreira, P., Fenstad, A. M., Furnes, O., & Hagen, K. B. Osteoarthritis and Cartilage, December, 2016. doi abstract bibtex OBJECTIVE: To explore and quantify the relative strengths of the genetic contribution vs the contribution of modifiable environmental factors to severe osteoarthritis (OA) having progressed to total joint arthroplasty. DESIGN: Incident data from the Norwegian Arthroplasty Registry were linked with the Norwegian Twin Registry on the National ID-number in 2014 in a population-based prospective cohort study of same-sex twins born 1915-60 (53.4% females). Education level and height/weight were self-reported and Body Mass Index (BMI) calculated. The total follow-up time was 27 years for hip arthroplasty (1987-2014, 424,914 person-years) and 20 years for knee arthroplasty (1994-2014, 306,207 person-years). We estimated concordances and the genetic contribution to arthroplasty due to OA in separate analyses for the hip and knee joint. RESULTS: The population comprised N = 9058 twin pairs (N = 3803 monozygotic (MZ), N = 5226 dizygotic (DZ)). In total, 73% (95% confidence intervals (CI) = 66-78%) and 45% (95% CI = 30-58%) of the respective variation in hip and knee arthroplasty could be explained by genetic factors. Zygosity (as a proxy for genetic factors) was associated with hip arthroplasty concordance over time when adjusted for sex, age, education and BMI (HR = 2.98, 95% CI = 1.90-4.67 for MZ compared to DZ twins). Knee arthroplasty was to a greater extent dependent on BMI when adjusted for zygosity and the other covariates (HR = 1.15, 95% CI = 1.02-1.29). CONCLUSION: Hip arthroplasty was strongly influenced by genetic factors whereas knee arthroplasty to a greater extent depended on a high BMI. The study may imply there is a greater potential for preventing progression of knee OA to arthroplasty in comparison with hip OA.
@article{magnusson_genetic_2016,
title = {Genetic factors contribute more to hip than knee surgery due to osteoarthritis - {A} population-based twin registry study of joint arthroplasty.},
issn = {1522-9653},
doi = {10.1016/j.joca.2016.12.015},
abstract = {OBJECTIVE: To explore and quantify the relative strengths of the genetic contribution vs the contribution of modifiable environmental factors to severe osteoarthritis (OA) having progressed to total joint arthroplasty.
DESIGN: Incident data from the Norwegian Arthroplasty Registry were linked with the Norwegian Twin Registry on the National ID-number in 2014 in a population-based prospective cohort study of same-sex twins born 1915-60 (53.4\% females). Education level and height/weight were self-reported and Body Mass Index (BMI) calculated. The total follow-up time was 27 years for hip arthroplasty (1987-2014, 424,914 person-years) and 20 years for knee arthroplasty (1994-2014, 306,207 person-years). We estimated concordances and the genetic contribution to arthroplasty due to OA in separate analyses for the hip and knee joint.
RESULTS: The population comprised N = 9058 twin pairs (N = 3803 monozygotic (MZ), N = 5226 dizygotic (DZ)). In total, 73\% (95\% confidence intervals (CI) = 66-78\%) and 45\% (95\% CI = 30-58\%) of the respective variation in hip and knee arthroplasty could be explained by genetic factors. Zygosity (as a proxy for genetic factors) was associated with hip arthroplasty concordance over time when adjusted for sex, age, education and BMI (HR = 2.98, 95\% CI = 1.90-4.67 for MZ compared to DZ twins). Knee arthroplasty was to a greater extent dependent on BMI when adjusted for zygosity and the other covariates (HR = 1.15, 95\% CI = 1.02-1.29).
CONCLUSION: Hip arthroplasty was strongly influenced by genetic factors whereas knee arthroplasty to a greater extent depended on a high BMI. The study may imply there is a greater potential for preventing progression of knee OA to arthroplasty in comparison with hip OA.},
language = {eng},
journal = {Osteoarthritis and Cartilage},
author = {Magnusson, K. and Scurrah, K. and Ystrom, E. and Ørstavik, R. E. and Nilsen, T. and Steingrímsdóttir, Ó A. and Ferreira, P. and Fenstad, A. M. and Furnes, O. and Hagen, K. B.},
month = dec,
year = {2016},
pmid = {27986619},
keywords = {Arthroplasty, Heritability, Osteoarthritis, Twins},
}
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{"_id":"NqDikfKmv4mXHRhSa","bibbaseid":"magnusson-scurrah-ystrom-rstavik-nilsen-steingrmsdttir-ferreira-fenstad-etal-geneticfactorscontributemoretohipthankneesurgeryduetoosteoarthritisapopulationbasedtwinregistrystudyofjointarthroplasty-2016","downloads":0,"creationDate":"2017-03-31T08:53:45.310Z","title":"Genetic factors contribute more to hip than knee surgery due to osteoarthritis - A population-based twin registry study of joint arthroplasty.","author_short":["Magnusson, K.","Scurrah, K.","Ystrom, E.","Ørstavik, R. E.","Nilsen, T.","Steingrímsdóttir, Ó A.","Ferreira, P.","Fenstad, A. M.","Furnes, O.","Hagen, K. B."],"year":2016,"bibtype":"article","biburl":"https://bibbase.org/zotero/ClinEpiLU","bibdata":{"bibtype":"article","type":"article","title":"Genetic factors contribute more to hip than knee surgery due to osteoarthritis - A population-based twin registry study of joint arthroplasty.","issn":"1522-9653","doi":"10.1016/j.joca.2016.12.015","abstract":"OBJECTIVE: To explore and quantify the relative strengths of the genetic contribution vs the contribution of modifiable environmental factors to severe osteoarthritis (OA) having progressed to total joint arthroplasty. DESIGN: Incident data from the Norwegian Arthroplasty Registry were linked with the Norwegian Twin Registry on the National ID-number in 2014 in a population-based prospective cohort study of same-sex twins born 1915-60 (53.4% females). Education level and height/weight were self-reported and Body Mass Index (BMI) calculated. The total follow-up time was 27 years for hip arthroplasty (1987-2014, 424,914 person-years) and 20 years for knee arthroplasty (1994-2014, 306,207 person-years). We estimated concordances and the genetic contribution to arthroplasty due to OA in separate analyses for the hip and knee joint. RESULTS: The population comprised N = 9058 twin pairs (N = 3803 monozygotic (MZ), N = 5226 dizygotic (DZ)). In total, 73% (95% confidence intervals (CI) = 66-78%) and 45% (95% CI = 30-58%) of the respective variation in hip and knee arthroplasty could be explained by genetic factors. Zygosity (as a proxy for genetic factors) was associated with hip arthroplasty concordance over time when adjusted for sex, age, education and BMI (HR = 2.98, 95% CI = 1.90-4.67 for MZ compared to DZ twins). Knee arthroplasty was to a greater extent dependent on BMI when adjusted for zygosity and the other covariates (HR = 1.15, 95% CI = 1.02-1.29). CONCLUSION: Hip arthroplasty was strongly influenced by genetic factors whereas knee arthroplasty to a greater extent depended on a high BMI. The study may imply there is a greater potential for preventing progression of knee OA to arthroplasty in comparison with hip OA.","language":"eng","journal":"Osteoarthritis and Cartilage","author":[{"propositions":[],"lastnames":["Magnusson"],"firstnames":["K."],"suffixes":[]},{"propositions":[],"lastnames":["Scurrah"],"firstnames":["K."],"suffixes":[]},{"propositions":[],"lastnames":["Ystrom"],"firstnames":["E."],"suffixes":[]},{"propositions":[],"lastnames":["Ørstavik"],"firstnames":["R.","E."],"suffixes":[]},{"propositions":[],"lastnames":["Nilsen"],"firstnames":["T."],"suffixes":[]},{"propositions":[],"lastnames":["Steingrímsdóttir"],"firstnames":["Ó","A."],"suffixes":[]},{"propositions":[],"lastnames":["Ferreira"],"firstnames":["P."],"suffixes":[]},{"propositions":[],"lastnames":["Fenstad"],"firstnames":["A.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Furnes"],"firstnames":["O."],"suffixes":[]},{"propositions":[],"lastnames":["Hagen"],"firstnames":["K.","B."],"suffixes":[]}],"month":"December","year":"2016","pmid":"27986619","keywords":"Arthroplasty, Heritability, Osteoarthritis, Twins","bibtex":"@article{magnusson_genetic_2016,\n\ttitle = {Genetic factors contribute more to hip than knee surgery due to osteoarthritis - {A} population-based twin registry study of joint arthroplasty.},\n\tissn = {1522-9653},\n\tdoi = {10.1016/j.joca.2016.12.015},\n\tabstract = {OBJECTIVE: To explore and quantify the relative strengths of the genetic contribution vs the contribution of modifiable environmental factors to severe osteoarthritis (OA) having progressed to total joint arthroplasty.\nDESIGN: Incident data from the Norwegian Arthroplasty Registry were linked with the Norwegian Twin Registry on the National ID-number in 2014 in a population-based prospective cohort study of same-sex twins born 1915-60 (53.4\\% females). Education level and height/weight were self-reported and Body Mass Index (BMI) calculated. The total follow-up time was 27 years for hip arthroplasty (1987-2014, 424,914 person-years) and 20 years for knee arthroplasty (1994-2014, 306,207 person-years). We estimated concordances and the genetic contribution to arthroplasty due to OA in separate analyses for the hip and knee joint.\nRESULTS: The population comprised N = 9058 twin pairs (N = 3803 monozygotic (MZ), N = 5226 dizygotic (DZ)). In total, 73\\% (95\\% confidence intervals (CI) = 66-78\\%) and 45\\% (95\\% CI = 30-58\\%) of the respective variation in hip and knee arthroplasty could be explained by genetic factors. Zygosity (as a proxy for genetic factors) was associated with hip arthroplasty concordance over time when adjusted for sex, age, education and BMI (HR = 2.98, 95\\% CI = 1.90-4.67 for MZ compared to DZ twins). Knee arthroplasty was to a greater extent dependent on BMI when adjusted for zygosity and the other covariates (HR = 1.15, 95\\% CI = 1.02-1.29).\nCONCLUSION: Hip arthroplasty was strongly influenced by genetic factors whereas knee arthroplasty to a greater extent depended on a high BMI. The study may imply there is a greater potential for preventing progression of knee OA to arthroplasty in comparison with hip OA.},\n\tlanguage = {eng},\n\tjournal = {Osteoarthritis and Cartilage},\n\tauthor = {Magnusson, K. and Scurrah, K. and Ystrom, E. and Ørstavik, R. E. and Nilsen, T. and Steingrímsdóttir, Ó A. and Ferreira, P. and Fenstad, A. M. and Furnes, O. and Hagen, K. B.},\n\tmonth = dec,\n\tyear = {2016},\n\tpmid = {27986619},\n\tkeywords = {Arthroplasty, Heritability, Osteoarthritis, Twins},\n}\n\n","author_short":["Magnusson, K.","Scurrah, K.","Ystrom, E.","Ørstavik, R. E.","Nilsen, T.","Steingrímsdóttir, Ó A.","Ferreira, P.","Fenstad, A. M.","Furnes, O.","Hagen, K. 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