The heritability of doctor-diagnosed traumatic and degenerative meniscus tears. Magnusson, K., Turkiewicz, A., Snoeker, B., Hughes, V., & Englund, M. Osteoarthritis and Cartilage, March, 2021. Publisher: Elsevier![The heritability of doctor-diagnosed traumatic and degenerative meniscus tears [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex \textlessh2\textgreaterSummary\textless/h2\textgreater\textlessh3\textgreaterObjective\textless/h3\textgreater\textlessp\textgreaterTo estimate the genetic contribution to traumatic and degenerative meniscus tears for men and women across the lifespan.\textless/p\textgreater\textlessh3\textgreaterMethods\textless/h3\textgreater\textlessp\textgreaterWe linked the Swedish Twin Register with individual-level national healthcare data to form a 30-year, population-wide, longitudinal twin cohort. To study genetic contribution to meniscus tears, we estimated the heritability and familial risk using incident traumatic and degenerative tear diagnostic codes in a cohort of 88,414 monozygotic and dizygotic twin-pairs, aged ≥17 years.\textless/p\textgreater\textlessh3\textgreaterResults\textless/h3\textgreater\textlessp\textgreaterDuring follow-up, 3,372 (3.8%) of 88,414 twins were diagnosed with a traumatic or degenerative meniscus tear\textbf. The heritability was 0.39 (95% CI = 0.32–0.47) for men and 0.43 (95% CI = 0.36–0.50) for women, and did not vary by age. Environmental factors that were unique to each twin in a pair explained a greater proportion of the variance than genetic factors, both for men (0.61, 95% CI = 0.53–0.68) and women (0.57, 95% CI = 0.50–0.64). Separate analyses of traumatic vs degenerative meniscus tears yielded similar results.\textless/p\textgreater\textlessh3\textgreaterConclusion\textless/h3\textgreater\textlessp\textgreaterFor the first time, we have estimated the genetic contribution to doctor-diagnosed meniscus tears using a twin study design. We found a relatively low to modest heritability for meniscus tears (∼40%). The heritability was also fairly stable over the lifespan, and equal in both men and women. Our findings suggest that environmental risk factors are a more important contributor to both traumatic and degenerative doctor-diagnosed meniscus tears than genetic factors.\textless/p\textgreater
@article{magnusson_heritability_2021,
title = {The heritability of doctor-diagnosed traumatic and degenerative meniscus tears},
volume = {In Press},
issn = {1063-4584, 1522-9653},
url = {https://www.oarsijournal.com/article/S1063-4584(21)00635-X/abstract},
doi = {10.1016/j.joca.2021.03.005},
abstract = {{\textless}h2{\textgreater}Summary{\textless}/h2{\textgreater}{\textless}h3{\textgreater}Objective{\textless}/h3{\textgreater}{\textless}p{\textgreater}To estimate the genetic contribution to traumatic and degenerative meniscus tears for men and women across the lifespan.{\textless}/p{\textgreater}{\textless}h3{\textgreater}Methods{\textless}/h3{\textgreater}{\textless}p{\textgreater}We linked the Swedish Twin Register with individual-level national healthcare data to form a 30-year, population-wide, longitudinal twin cohort. To study genetic contribution to meniscus tears, we estimated the heritability and familial risk using incident traumatic and degenerative tear diagnostic codes in a cohort of 88,414 monozygotic and dizygotic twin-pairs, aged ≥17 years.{\textless}/p{\textgreater}{\textless}h3{\textgreater}Results{\textless}/h3{\textgreater}{\textless}p{\textgreater}During follow-up, 3,372 (3.8\%) of 88,414 twins were diagnosed with a traumatic or degenerative meniscus tear\textbf{.} The heritability was 0.39 (95\% CI = 0.32–0.47) for men and 0.43 (95\% CI = 0.36–0.50) for women, and did not vary by age. Environmental factors that were unique to each twin in a pair explained a greater proportion of the variance than genetic factors, both for men (0.61, 95\% CI = 0.53–0.68) and women (0.57, 95\% CI = 0.50–0.64). Separate analyses of traumatic vs degenerative meniscus tears yielded similar results.{\textless}/p{\textgreater}{\textless}h3{\textgreater}Conclusion{\textless}/h3{\textgreater}{\textless}p{\textgreater}For the first time, we have estimated the genetic contribution to doctor-diagnosed meniscus tears using a twin study design. We found a relatively low to modest heritability for meniscus tears (∼40\%). The heritability was also fairly stable over the lifespan, and equal in both men and women. Our findings suggest that environmental risk factors are a more important contributor to both traumatic and degenerative doctor-diagnosed meniscus tears than genetic factors.{\textless}/p{\textgreater}},
language = {English},
urldate = {2021-04-01},
journal = {Osteoarthritis and Cartilage},
author = {Magnusson, K. and Turkiewicz, A. and Snoeker, B. and Hughes, V. and Englund, M.},
month = mar,
year = {2021},
note = {Publisher: Elsevier},
}
Downloads: 0
{"_id":"h5xDHcebNwcuSrxY8","bibbaseid":"magnusson-turkiewicz-snoeker-hughes-englund-theheritabilityofdoctordiagnosedtraumaticanddegenerativemeniscustears-2021","author_short":["Magnusson, K.","Turkiewicz, A.","Snoeker, B.","Hughes, V.","Englund, M."],"bibdata":{"bibtype":"article","type":"article","title":"The heritability of doctor-diagnosed traumatic and degenerative meniscus tears","volume":"In Press","issn":"1063-4584, 1522-9653","url":"https://www.oarsijournal.com/article/S1063-4584(21)00635-X/abstract","doi":"10.1016/j.joca.2021.03.005","abstract":"\\textlessh2\\textgreaterSummary\\textless/h2\\textgreater\\textlessh3\\textgreaterObjective\\textless/h3\\textgreater\\textlessp\\textgreaterTo estimate the genetic contribution to traumatic and degenerative meniscus tears for men and women across the lifespan.\\textless/p\\textgreater\\textlessh3\\textgreaterMethods\\textless/h3\\textgreater\\textlessp\\textgreaterWe linked the Swedish Twin Register with individual-level national healthcare data to form a 30-year, population-wide, longitudinal twin cohort. To study genetic contribution to meniscus tears, we estimated the heritability and familial risk using incident traumatic and degenerative tear diagnostic codes in a cohort of 88,414 monozygotic and dizygotic twin-pairs, aged ≥17 years.\\textless/p\\textgreater\\textlessh3\\textgreaterResults\\textless/h3\\textgreater\\textlessp\\textgreaterDuring follow-up, 3,372 (3.8%) of 88,414 twins were diagnosed with a traumatic or degenerative meniscus tear\\textbf. The heritability was 0.39 (95% CI = 0.32–0.47) for men and 0.43 (95% CI = 0.36–0.50) for women, and did not vary by age. Environmental factors that were unique to each twin in a pair explained a greater proportion of the variance than genetic factors, both for men (0.61, 95% CI = 0.53–0.68) and women (0.57, 95% CI = 0.50–0.64). Separate analyses of traumatic vs degenerative meniscus tears yielded similar results.\\textless/p\\textgreater\\textlessh3\\textgreaterConclusion\\textless/h3\\textgreater\\textlessp\\textgreaterFor the first time, we have estimated the genetic contribution to doctor-diagnosed meniscus tears using a twin study design. We found a relatively low to modest heritability for meniscus tears (∼40%). The heritability was also fairly stable over the lifespan, and equal in both men and women. Our findings suggest that environmental risk factors are a more important contributor to both traumatic and degenerative doctor-diagnosed meniscus tears than genetic factors.\\textless/p\\textgreater","language":"English","urldate":"2021-04-01","journal":"Osteoarthritis and Cartilage","author":[{"propositions":[],"lastnames":["Magnusson"],"firstnames":["K."],"suffixes":[]},{"propositions":[],"lastnames":["Turkiewicz"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Snoeker"],"firstnames":["B."],"suffixes":[]},{"propositions":[],"lastnames":["Hughes"],"firstnames":["V."],"suffixes":[]},{"propositions":[],"lastnames":["Englund"],"firstnames":["M."],"suffixes":[]}],"month":"March","year":"2021","note":"Publisher: Elsevier","bibtex":"@article{magnusson_heritability_2021,\n\ttitle = {The heritability of doctor-diagnosed traumatic and degenerative meniscus tears},\n\tvolume = {In Press},\n\tissn = {1063-4584, 1522-9653},\n\turl = {https://www.oarsijournal.com/article/S1063-4584(21)00635-X/abstract},\n\tdoi = {10.1016/j.joca.2021.03.005},\n\tabstract = {{\\textless}h2{\\textgreater}Summary{\\textless}/h2{\\textgreater}{\\textless}h3{\\textgreater}Objective{\\textless}/h3{\\textgreater}{\\textless}p{\\textgreater}To estimate the genetic contribution to traumatic and degenerative meniscus tears for men and women across the lifespan.{\\textless}/p{\\textgreater}{\\textless}h3{\\textgreater}Methods{\\textless}/h3{\\textgreater}{\\textless}p{\\textgreater}We linked the Swedish Twin Register with individual-level national healthcare data to form a 30-year, population-wide, longitudinal twin cohort. To study genetic contribution to meniscus tears, we estimated the heritability and familial risk using incident traumatic and degenerative tear diagnostic codes in a cohort of 88,414 monozygotic and dizygotic twin-pairs, aged ≥17 years.{\\textless}/p{\\textgreater}{\\textless}h3{\\textgreater}Results{\\textless}/h3{\\textgreater}{\\textless}p{\\textgreater}During follow-up, 3,372 (3.8\\%) of 88,414 twins were diagnosed with a traumatic or degenerative meniscus tear\\textbf{.} The heritability was 0.39 (95\\% CI = 0.32–0.47) for men and 0.43 (95\\% CI = 0.36–0.50) for women, and did not vary by age. Environmental factors that were unique to each twin in a pair explained a greater proportion of the variance than genetic factors, both for men (0.61, 95\\% CI = 0.53–0.68) and women (0.57, 95\\% CI = 0.50–0.64). Separate analyses of traumatic vs degenerative meniscus tears yielded similar results.{\\textless}/p{\\textgreater}{\\textless}h3{\\textgreater}Conclusion{\\textless}/h3{\\textgreater}{\\textless}p{\\textgreater}For the first time, we have estimated the genetic contribution to doctor-diagnosed meniscus tears using a twin study design. We found a relatively low to modest heritability for meniscus tears (∼40\\%). The heritability was also fairly stable over the lifespan, and equal in both men and women. Our findings suggest that environmental risk factors are a more important contributor to both traumatic and degenerative doctor-diagnosed meniscus tears than genetic factors.{\\textless}/p{\\textgreater}},\n\tlanguage = {English},\n\turldate = {2021-04-01},\n\tjournal = {Osteoarthritis and Cartilage},\n\tauthor = {Magnusson, K. and Turkiewicz, A. and Snoeker, B. and Hughes, V. and Englund, M.},\n\tmonth = mar,\n\tyear = {2021},\n\tnote = {Publisher: Elsevier},\n}\n\n","author_short":["Magnusson, K.","Turkiewicz, A.","Snoeker, B.","Hughes, V.","Englund, M."],"key":"magnusson_heritability_2021","id":"magnusson_heritability_2021","bibbaseid":"magnusson-turkiewicz-snoeker-hughes-englund-theheritabilityofdoctordiagnosedtraumaticanddegenerativemeniscustears-2021","role":"author","urls":{"Paper":"https://www.oarsijournal.com/article/S1063-4584(21)00635-X/abstract"},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://api.zotero.org/groups/5155143/items?key=IVTAjWy1U5EkGJqE2Z2qQCfh&format=bibtex&limit=100","dataSources":["7PYyrRz6AvkoBBchz","NGDbv8dMYDaDn8kqm","5jEuhQhgRx3py8LmG","LPTeGao77ndnG4Tks"],"keywords":[],"search_terms":["heritability","doctor","diagnosed","traumatic","degenerative","meniscus","tears","magnusson","turkiewicz","snoeker","hughes","englund"],"title":"The heritability of doctor-diagnosed traumatic and degenerative meniscus tears","year":2021}