@article{maher_divergent_2021,
	title = {Divergent leukaemia subclones as cellular models for testing vulnerabilities associated with gains in chromosomes 7, 8 or 18},
	volume = {11},
	copyright = {2021 The Author(s)},
	issn = {2045-2322},
	url = {https://www.nature.com/articles/s41598-021-00623-w},
	doi = {10.1038/s41598-021-00623-w},
	abstract = {Haematopoietic malignancies are frequently characterized by karyotypic abnormalities. The development of targeted drugs has been pioneered with compounds against gene products of fusion genes caused by chromosomal translocations. While polysomies are equally frequent as translocations, for many of them we are lacking therapeutic approaches aimed at synthetic lethality. Here, we report two new cell lines, named MBU-7 and MBU-8, that differ in complete trisomy of chromosome18, a partial trisomy of chromosome 7 and a tetrasomy of the p-arm of chromosome 8, but otherwise share the same mutational pattern and complex karyotype. Both cell lines are divergent clones of U-937 cells and have the morphology and immunoprofile of monocytic cells. The distinct karyotypic differences between MBU-7 and MBU-8 are associated with a difference in the specific response to nucleoside analogues. Taken together, we propose the MBU-7 and MBU-8 cell lines described here as suitable in vitro models for screening and testing vulnerabilities that are associated with the disease-relevant polysomies of chromosome 7, 8 and 18.},
	language = {en},
	number = {1},
	urldate = {2021-11-11},
	journal = {Scientific Reports},
	author = {Maher, Michael and Diesch, Jeannine and Le Pannérer, Marguerite-Marie and Cabezón, Marta and Mallo, Mar and Vergara, Sara and Méndez López, Aleix and Mesa Tudel, Alba and Solé, Francesc and Sorigue, Marc and Zamora, Lurdes and Granada, Isabel and Buschbeck, Marcus},
	month = oct,
	year = {2021},
	note = {Bandiera\_abtest: a
Cc\_license\_type: cc\_by
Cg\_type: Nature Research Journals
Number: 1
Primary\_atype: Research
Publisher: Nature Publishing Group
Subject\_term: Acute myeloid leukaemia;Biomarkers;Cancer genetics;Haematological cancer;Translational research
Subject\_term\_id: acute-myeloid-leukaemia;biomarkers;cancer-genetics;haematological-cancer;translational-research},
	keywords = {Acute myeloid leukaemia, Biomarkers, Cancer genetics, Haematological cancer, MYS, SOPHiA DDM, Translational research},
	pages = {21145},
}

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The development of targeted drugs has been pioneered with compounds against gene products of fusion genes caused by chromosomal translocations. While polysomies are equally frequent as translocations, for many of them we are lacking therapeutic approaches aimed at synthetic lethality. Here, we report two new cell lines, named MBU-7 and MBU-8, that differ in complete trisomy of chromosome18, a partial trisomy of chromosome 7 and a tetrasomy of the p-arm of chromosome 8, but otherwise share the same mutational pattern and complex karyotype. Both cell lines are divergent clones of U-937 cells and have the morphology and immunoprofile of monocytic cells. The distinct karyotypic differences between MBU-7 and MBU-8 are associated with a difference in the specific response to nucleoside analogues. Taken together, we propose the MBU-7 and MBU-8 cell lines described here as suitable in vitro models for screening and testing vulnerabilities that are associated with the disease-relevant polysomies of chromosome 7, 8 and 18.","language":"en","number":"1","urldate":"2021-11-11","journal":"Scientific Reports","author":[{"propositions":[],"lastnames":["Maher"],"firstnames":["Michael"],"suffixes":[]},{"propositions":[],"lastnames":["Diesch"],"firstnames":["Jeannine"],"suffixes":[]},{"propositions":[],"lastnames":["Le","Pannérer"],"firstnames":["Marguerite-Marie"],"suffixes":[]},{"propositions":[],"lastnames":["Cabezón"],"firstnames":["Marta"],"suffixes":[]},{"propositions":[],"lastnames":["Mallo"],"firstnames":["Mar"],"suffixes":[]},{"propositions":[],"lastnames":["Vergara"],"firstnames":["Sara"],"suffixes":[]},{"propositions":[],"lastnames":["Méndez","López"],"firstnames":["Aleix"],"suffixes":[]},{"propositions":[],"lastnames":["Mesa","Tudel"],"firstnames":["Alba"],"suffixes":[]},{"propositions":[],"lastnames":["Solé"],"firstnames":["Francesc"],"suffixes":[]},{"propositions":[],"lastnames":["Sorigue"],"firstnames":["Marc"],"suffixes":[]},{"propositions":[],"lastnames":["Zamora"],"firstnames":["Lurdes"],"suffixes":[]},{"propositions":[],"lastnames":["Granada"],"firstnames":["Isabel"],"suffixes":[]},{"propositions":[],"lastnames":["Buschbeck"],"firstnames":["Marcus"],"suffixes":[]}],"month":"October","year":"2021","note":"Bandiera_abtest: a Cc_license_type: cc_by Cg_type: Nature Research Journals Number: 1 Primary_atype: Research Publisher: Nature Publishing Group Subject_term: Acute myeloid leukaemia;Biomarkers;Cancer genetics;Haematological cancer;Translational research Subject_term_id: acute-myeloid-leukaemia;biomarkers;cancer-genetics;haematological-cancer;translational-research","keywords":"Acute myeloid leukaemia, Biomarkers, Cancer genetics, Haematological cancer, MYS, SOPHiA DDM, Translational research","pages":"21145","bibtex":"@article{maher_divergent_2021,\n\ttitle = {Divergent leukaemia subclones as cellular models for testing vulnerabilities associated with gains in chromosomes 7, 8 or 18},\n\tvolume = {11},\n\tcopyright = {2021 The Author(s)},\n\tissn = {2045-2322},\n\turl = {https://www.nature.com/articles/s41598-021-00623-w},\n\tdoi = {10.1038/s41598-021-00623-w},\n\tabstract = {Haematopoietic malignancies are frequently characterized by karyotypic abnormalities. The development of targeted drugs has been pioneered with compounds against gene products of fusion genes caused by chromosomal translocations. While polysomies are equally frequent as translocations, for many of them we are lacking therapeutic approaches aimed at synthetic lethality. Here, we report two new cell lines, named MBU-7 and MBU-8, that differ in complete trisomy of chromosome18, a partial trisomy of chromosome 7 and a tetrasomy of the p-arm of chromosome 8, but otherwise share the same mutational pattern and complex karyotype. Both cell lines are divergent clones of U-937 cells and have the morphology and immunoprofile of monocytic cells. The distinct karyotypic differences between MBU-7 and MBU-8 are associated with a difference in the specific response to nucleoside analogues. Taken together, we propose the MBU-7 and MBU-8 cell lines described here as suitable in vitro models for screening and testing vulnerabilities that are associated with the disease-relevant polysomies of chromosome 7, 8 and 18.},\n\tlanguage = {en},\n\tnumber = {1},\n\turldate = {2021-11-11},\n\tjournal = {Scientific Reports},\n\tauthor = {Maher, Michael and Diesch, Jeannine and Le Pannérer, Marguerite-Marie and Cabezón, Marta and Mallo, Mar and Vergara, Sara and Méndez López, Aleix and Mesa Tudel, Alba and Solé, Francesc and Sorigue, Marc and Zamora, Lurdes and Granada, Isabel and Buschbeck, Marcus},\n\tmonth = oct,\n\tyear = {2021},\n\tnote = {Bandiera\\_abtest: a\nCc\\_license\\_type: cc\\_by\nCg\\_type: Nature Research Journals\nNumber: 1\nPrimary\\_atype: Research\nPublisher: Nature Publishing Group\nSubject\\_term: Acute myeloid leukaemia;Biomarkers;Cancer genetics;Haematological cancer;Translational research\nSubject\\_term\\_id: acute-myeloid-leukaemia;biomarkers;cancer-genetics;haematological-cancer;translational-research},\n\tkeywords = {Acute myeloid leukaemia, Biomarkers, Cancer genetics, Haematological cancer, MYS, SOPHiA DDM, Translational research},\n\tpages = {21145},\n}\n\n\n\n\n\n\n\n\n\n\n\n","author_short":["Maher, M.","Diesch, J.","Le Pannérer, M.","Cabezón, M.","Mallo, M.","Vergara, S.","Méndez López, A.","Mesa Tudel, A.","Solé, F.","Sorigue, M.","Zamora, L.","Granada, I.","Buschbeck, M."],"key":"maher_divergent_2021","id":"maher_divergent_2021","bibbaseid":"maher-diesch-lepannrer-cabezn-mallo-vergara-mndezlpez-mesatudel-etal-divergentleukaemiasubclonesascellularmodelsfortestingvulnerabilitiesassociatedwithgainsinchromosomes78or18-2021","role":"author","urls":{"Paper":"https://www.nature.com/articles/s41598-021-00623-w"},"keyword":["Acute myeloid leukaemia","Biomarkers","Cancer genetics","Haematological cancer","MYS","SOPHiA DDM","Translational research"],"metadata":{"authorlinks":{}},"downloads":6},"bibtype":"article","biburl":"https://bibbase.org/zotero/SOPHiAGENETICS","dataSources":["Pcpsxmwz8uxXtL843","vPYMrJTaJTbhFPPb4"],"keywords":["acute myeloid leukaemia","biomarkers","cancer genetics","haematological cancer","mys","sophia ddm","translational research"],"search_terms":["divergent","leukaemia","subclones","cellular","models","testing","vulnerabilities","associated","gains","chromosomes","maher","diesch","le pannérer","cabezón","mallo","vergara","méndez lópez","mesa tudel","solé","sorigue","zamora","granada","buschbeck"],"title":"Divergent leukaemia subclones as cellular models for testing vulnerabilities associated with gains in chromosomes 7, 8 or 18","year":2021,"downloads":6}