The FA2 gene of Chlamydomonas encodes a NIMA family kinase with roles in cell cycle progression and microtubule severing during deflagellation. Mahjoub, M. R., Montpetit, B., Zhao, L., Finst, R. J., Goh, B., Kim, A. C., & Quarmby, L. M. J Cell Sci, 115(Pt 8):1759–1768, 4, 2002. [DOI:\hrefhttps://dx.doi.org/10.1242/jcs.115.8.175910.1242/jcs.115.8.1759] [PubMed:\hrefhttps://www.ncbi.nlm.nih.gov/pubmed/1195089211950892] abstract bibtex The NIMA kinases are one of several families of kinases that participate in driving the eukaryotic cell cycle. NIMA-related kinases have been implicated in G2/M progression, chromatin condensation and regulation of the centrosome cycle. Here we report the identification of a new member of this family, FA2, from Chlamydomonas reinhardtii. FA2 was originally discovered in a genetic screen for deflagellation-defective mutants. We have previously shown that FA2 is essential for basal-body/centriole-associated microtubule severing. We now report that the FA2 NIMA-related kinase also plays a role in cell cycle progression in Chlamydomonas. This is the first indication that members of the NIMA family might exert their effects through the regulation of microtubule severing.
@Article{mahjoub2002,
Author="Mahjoub, M. R. and Montpetit, B. and Zhao, L. and Finst, R. J. and Goh, B. and Kim, A. C. and Quarmby, L. M. ",
Title="{{T}he {F}{A}2 gene of {C}hlamydomonas encodes a {N}{I}{M}{A} family kinase with roles in cell cycle progression and microtubule severing during deflagellation}",
Journal="J Cell Sci",
Year="2002",
Volume="115",
Number="Pt 8",
Pages="1759--1768",
Month="4",
Abstract={The NIMA kinases are one of several families of kinases that participate in driving the eukaryotic cell cycle. NIMA-related kinases have been implicated in G2/M progression, chromatin condensation and regulation of the centrosome cycle. Here we report the identification of a new member of this family, FA2, from Chlamydomonas reinhardtii. FA2 was originally discovered in a genetic screen for deflagellation-defective mutants. We have previously shown that FA2 is essential for basal-body/centriole-associated microtubule severing. We now report that the FA2 NIMA-related kinase also plays a role in cell cycle progression in Chlamydomonas. This is the first indication that members of the NIMA family might exert their effects through the regulation of microtubule severing.},
Note={[DOI:\href{https://dx.doi.org/10.1242/jcs.115.8.1759}{10.1242/jcs.115.8.1759}] [PubMed:\href{https://www.ncbi.nlm.nih.gov/pubmed/11950892}{11950892}] }
}
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