Survival after reconstructive surgery for hypoplastic left heart syndrome: A 15-year experience from a single institution. Mahle, W., Spray, T., Wernovsky, G, Gaynor, J., & Clark, B. Circulation, 102(19 Suppl 3):III136–III141, November, 2000. ![Survival after reconstructive surgery for hypoplastic left heart syndrome: A 15-year experience from a single institution. [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper abstract bibtex BACKGROUND: There are limited data regarding the long-term survival of patients who have undergone reconstructive surgery for hypoplastic left heart syndrome (HLHS). We reviewed the 15-year experience at our institution to examine survival in the context of continued improvements in early operative results. METHODS AND RESULTS: Between 1984 and 1999, 840 patients underwent stage I surgery for HLHS. From review of medical records and direct patient contact, survival status was determined. The 1-, 2-, 5-, 10-, and 15-year survival for the entire cohort was 51%, 43%, 40%, 39%, and 39%, respectively. Late death occurred in 14 of the 291 patients discharged to home after the Fontan procedure, although only 1 patient has died beyond 5 years of age. Heart transplantation after stage I reconstruction was performed in 5 patients. Later era of stage I surgery was associated with significantly improved survival (P:\textless0.001). Three-year survival for patients undergoing stage I reconstruction from 1995 to 1998 was 66% versus 28% for those patients undergoing surgery from 1984 to 1988. Age \textgreater14 days at stage I and weight \textless2.5 kg at stage I were also associated with higher mortality (P:=0.004 and P:=0.01, respectively). Other variables, including anatomic subtype, heterotaxia, and age at subsequent staging procedures, were not associated with survival. CONCLUSIONS: Over the 15-year course of this study, early- and intermediate-term survival for patients with HLHS undergoing staged palliation increased significantly. Late death and the need for cardiac transplantation were uncommon.
@article{mahle_survival_2000,
title = {Survival after reconstructive surgery for hypoplastic left heart syndrome: {A} 15-year experience from a single institution.},
volume = {102},
url = {https://www.ncbi.nlm.nih.gov/pubmed/11082376},
abstract = {BACKGROUND: There are limited data regarding the long-term survival of patients who have undergone reconstructive surgery for hypoplastic left heart syndrome (HLHS). We reviewed the 15-year experience at our institution to examine survival in the context of continued improvements in early operative results. METHODS AND RESULTS: Between 1984 and 1999, 840 patients underwent stage I surgery for HLHS. From review of medical records and direct patient contact, survival status was determined. The 1-, 2-, 5-, 10-, and 15-year survival for the entire cohort was 51\%, 43\%, 40\%, 39\%, and 39\%, respectively. Late death occurred in 14 of the 291 patients discharged to home after the Fontan procedure, although only 1 patient has died beyond 5 years of age. Heart transplantation after stage I reconstruction was performed in 5 patients. Later era of stage I surgery was associated with significantly improved survival (P:{\textless}0.001). Three-year survival for patients undergoing stage I reconstruction from 1995 to 1998 was 66\% versus 28\% for those patients undergoing surgery from 1984 to 1988. Age {\textgreater}14 days at stage I and weight {\textless}2.5 kg at stage I were also associated with higher mortality (P:=0.004 and P:=0.01, respectively). Other variables, including anatomic subtype, heterotaxia, and age at subsequent staging procedures, were not associated with survival. CONCLUSIONS: Over the 15-year course of this study, early- and intermediate-term survival for patients with HLHS undergoing staged palliation increased significantly. Late death and the need for cardiac transplantation were uncommon.},
language = {eng},
number = {19 Suppl 3},
journal = {Circulation},
author = {Mahle, WT and Spray, TL and Wernovsky, G and Gaynor, JW and Clark, BJ},
month = nov,
year = {2000},
keywords = {Treatment Outcome},
pages = {III136--III141}
}
Downloads: 0
{"_id":"7wiC7q7dckYftwaev","bibbaseid":"mahle-spray-wernovsky-gaynor-clark-survivalafterreconstructivesurgeryforhypoplasticleftheartsyndromea15yearexperiencefromasingleinstitution-2000","downloads":0,"creationDate":"2019-02-06T19:35:20.751Z","title":"Survival after reconstructive surgery for hypoplastic left heart syndrome: A 15-year experience from a single institution.","author_short":["Mahle, W.","Spray, T.","Wernovsky, G","Gaynor, J.","Clark, B."],"year":2000,"bibtype":"article","biburl":"https://api.zotero.org/users/5494130/collections/TR8UM4WJ/items?key=DEUYuiNYuDld2Xdzn5K5sy3H&format=bibtex&limit=100","bibdata":{"bibtype":"article","type":"article","title":"Survival after reconstructive surgery for hypoplastic left heart syndrome: A 15-year experience from a single institution.","volume":"102","url":"https://www.ncbi.nlm.nih.gov/pubmed/11082376","abstract":"BACKGROUND: There are limited data regarding the long-term survival of patients who have undergone reconstructive surgery for hypoplastic left heart syndrome (HLHS). We reviewed the 15-year experience at our institution to examine survival in the context of continued improvements in early operative results. METHODS AND RESULTS: Between 1984 and 1999, 840 patients underwent stage I surgery for HLHS. From review of medical records and direct patient contact, survival status was determined. The 1-, 2-, 5-, 10-, and 15-year survival for the entire cohort was 51%, 43%, 40%, 39%, and 39%, respectively. Late death occurred in 14 of the 291 patients discharged to home after the Fontan procedure, although only 1 patient has died beyond 5 years of age. Heart transplantation after stage I reconstruction was performed in 5 patients. Later era of stage I surgery was associated with significantly improved survival (P:\\textless0.001). Three-year survival for patients undergoing stage I reconstruction from 1995 to 1998 was 66% versus 28% for those patients undergoing surgery from 1984 to 1988. Age \\textgreater14 days at stage I and weight \\textless2.5 kg at stage I were also associated with higher mortality (P:=0.004 and P:=0.01, respectively). Other variables, including anatomic subtype, heterotaxia, and age at subsequent staging procedures, were not associated with survival. CONCLUSIONS: Over the 15-year course of this study, early- and intermediate-term survival for patients with HLHS undergoing staged palliation increased significantly. Late death and the need for cardiac transplantation were uncommon.","language":"eng","number":"19 Suppl 3","journal":"Circulation","author":[{"propositions":[],"lastnames":["Mahle"],"firstnames":["WT"],"suffixes":[]},{"propositions":[],"lastnames":["Spray"],"firstnames":["TL"],"suffixes":[]},{"propositions":[],"lastnames":["Wernovsky"],"firstnames":["G"],"suffixes":[]},{"propositions":[],"lastnames":["Gaynor"],"firstnames":["JW"],"suffixes":[]},{"propositions":[],"lastnames":["Clark"],"firstnames":["BJ"],"suffixes":[]}],"month":"November","year":"2000","keywords":"Treatment Outcome","pages":"III136–III141","bibtex":"@article{mahle_survival_2000,\n\ttitle = {Survival after reconstructive surgery for hypoplastic left heart syndrome: {A} 15-year experience from a single institution.},\n\tvolume = {102},\n\turl = {https://www.ncbi.nlm.nih.gov/pubmed/11082376},\n\tabstract = {BACKGROUND: There are limited data regarding the long-term survival of patients who have undergone reconstructive surgery for hypoplastic left heart syndrome (HLHS). We reviewed the 15-year experience at our institution to examine survival in the context of continued improvements in early operative results. METHODS AND RESULTS: Between 1984 and 1999, 840 patients underwent stage I surgery for HLHS. From review of medical records and direct patient contact, survival status was determined. The 1-, 2-, 5-, 10-, and 15-year survival for the entire cohort was 51\\%, 43\\%, 40\\%, 39\\%, and 39\\%, respectively. Late death occurred in 14 of the 291 patients discharged to home after the Fontan procedure, although only 1 patient has died beyond 5 years of age. Heart transplantation after stage I reconstruction was performed in 5 patients. Later era of stage I surgery was associated with significantly improved survival (P:{\\textless}0.001). Three-year survival for patients undergoing stage I reconstruction from 1995 to 1998 was 66\\% versus 28\\% for those patients undergoing surgery from 1984 to 1988. Age {\\textgreater}14 days at stage I and weight {\\textless}2.5 kg at stage I were also associated with higher mortality (P:=0.004 and P:=0.01, respectively). Other variables, including anatomic subtype, heterotaxia, and age at subsequent staging procedures, were not associated with survival. CONCLUSIONS: Over the 15-year course of this study, early- and intermediate-term survival for patients with HLHS undergoing staged palliation increased significantly. Late death and the need for cardiac transplantation were uncommon.},\n\tlanguage = {eng},\n\tnumber = {19 Suppl 3},\n\tjournal = {Circulation},\n\tauthor = {Mahle, WT and Spray, TL and Wernovsky, G and Gaynor, JW and Clark, BJ},\n\tmonth = nov,\n\tyear = {2000},\n\tkeywords = {Treatment Outcome},\n\tpages = {III136--III141}\n}\n\n","author_short":["Mahle, W.","Spray, T.","Wernovsky, G","Gaynor, J.","Clark, B."],"key":"mahle_survival_2000","id":"mahle_survival_2000","bibbaseid":"mahle-spray-wernovsky-gaynor-clark-survivalafterreconstructivesurgeryforhypoplasticleftheartsyndromea15yearexperiencefromasingleinstitution-2000","role":"author","urls":{"Paper":"https://www.ncbi.nlm.nih.gov/pubmed/11082376"},"keyword":["Treatment Outcome"],"downloads":0,"html":""},"search_terms":["survival","reconstructive","surgery","hypoplastic","left","heart","syndrome","year","experience","single","institution","mahle","spray","wernovsky","gaynor","clark"],"keywords":["treatment outcome"],"authorIDs":[],"dataSources":["hCDpMxm2W25GkFxwp"]}