Fasting alters the gut microbiome reducing blood pressure and body weight in metabolic syndrome patients. Maifeld, A., Bartolomaeus, H., Löber, U., Avery, E. G., Steckhan, N., Markó, L., Wilck, N., Hamad, I., Šušnjar, U., Mähler, A., Hohmann, C., Chen, C., Cramer, H., Dobos, G., Lesker, T. R., Strowig, T., Dechend, R., Bzdok, D., Kleinewietfeld, M., Michalsen, A., Müller, D. N., & Forslund, S. K. Nature Communications, 12(1):1970, March, 2021. Number: 1 Publisher: Nature Publishing Group![Fasting alters the gut microbiome reducing blood pressure and body weight in metabolic syndrome patients [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Periods of fasting and refeeding may reduce cardiometabolic risk elevated by Western diet. Here we show in the substudy of NCT02099968, investigating the clinical parameters, the immunome and gut microbiome exploratory endpoints, that in hypertensive metabolic syndrome patients, a 5-day fast followed by a modified Dietary Approach to Stop Hypertension diet reduces systolic blood pressure, need for antihypertensive medications, body-mass index at three months post intervention compared to a modified Dietary Approach to Stop Hypertension diet alone. Fasting alters the gut microbiome, impacting bacterial taxa and gene modules associated with short-chain fatty acid production. Cross-system analyses reveal a positive correlation of circulating mucosa-associated invariant T cells, non-classical monocytes and CD4+ effector T cells with systolic blood pressure. Furthermore, regulatory T cells positively correlate with body-mass index and weight. Machine learning analysis of baseline immunome or microbiome data predicts sustained systolic blood pressure response within the fasting group, identifying CD8+ effector T cells, Th17 cells and regulatory T cells or Desulfovibrionaceae, Hydrogenoanaerobacterium, Akkermansia, and Ruminococcaceae as important contributors to the model. Here we report that the high-resolution multi-omics data highlight fasting as a promising non-pharmacological intervention for the treatment of high blood pressure in metabolic syndrome patients.
@article{maifeld_fasting_2021,
title = {Fasting alters the gut microbiome reducing blood pressure and body weight in metabolic syndrome patients},
volume = {12},
copyright = {2021 The Author(s)},
issn = {2041-1723},
url = {https://www.nature.com/articles/s41467-021-22097-0},
doi = {10.1038/s41467-021-22097-0},
abstract = {Periods of fasting and refeeding may reduce cardiometabolic risk elevated by Western diet. Here we show in the substudy of NCT02099968, investigating the clinical parameters, the immunome and gut microbiome exploratory endpoints, that in hypertensive metabolic syndrome patients, a 5-day fast followed by a modified Dietary Approach to Stop Hypertension diet reduces systolic blood pressure, need for antihypertensive medications, body-mass index at three months post intervention compared to a modified Dietary Approach to Stop Hypertension diet alone. Fasting alters the gut microbiome, impacting bacterial taxa and gene modules associated with short-chain fatty acid production. Cross-system analyses reveal a positive correlation of circulating mucosa-associated invariant T cells, non-classical monocytes and CD4+ effector T cells with systolic blood pressure. Furthermore, regulatory T cells positively correlate with body-mass index and weight. Machine learning analysis of baseline immunome or microbiome data predicts sustained systolic blood pressure response within the fasting group, identifying CD8+ effector T cells, Th17 cells and regulatory T cells or Desulfovibrionaceae, Hydrogenoanaerobacterium, Akkermansia, and Ruminococcaceae as important contributors to the model. Here we report that the high-resolution multi-omics data highlight fasting as a promising non-pharmacological intervention for the treatment of high blood pressure in metabolic syndrome patients.},
language = {en},
number = {1},
urldate = {2021-03-31},
journal = {Nature Communications},
author = {Maifeld, András and Bartolomaeus, Hendrik and Löber, Ulrike and Avery, Ellen G. and Steckhan, Nico and Markó, Lajos and Wilck, Nicola and Hamad, Ibrahim and Šušnjar, Urša and Mähler, Anja and Hohmann, Christoph and Chen, Chia-Yu and Cramer, Holger and Dobos, Gustav and Lesker, Till Robin and Strowig, Till and Dechend, Ralf and Bzdok, Danilo and Kleinewietfeld, Markus and Michalsen, Andreas and Müller, Dominik N. and Forslund, Sofia K.},
month = mar,
year = {2021},
note = {Number: 1
Publisher: Nature Publishing Group},
pages = {1970},
}
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Here we show in the substudy of NCT02099968, investigating the clinical parameters, the immunome and gut microbiome exploratory endpoints, that in hypertensive metabolic syndrome patients, a 5-day fast followed by a modified Dietary Approach to Stop Hypertension diet reduces systolic blood pressure, need for antihypertensive medications, body-mass index at three months post intervention compared to a modified Dietary Approach to Stop Hypertension diet alone. Fasting alters the gut microbiome, impacting bacterial taxa and gene modules associated with short-chain fatty acid production. Cross-system analyses reveal a positive correlation of circulating mucosa-associated invariant T cells, non-classical monocytes and CD4+ effector T cells with systolic blood pressure. Furthermore, regulatory T cells positively correlate with body-mass index and weight. 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