Gastrinoma of the common bile duct: immunohistochemical and ultrastructural study of a case. Mandujano-Vera, G., Angeles-Angeles, A., de la Cruz-Hernández, J., Sansores-Pérez, M., & Larriva-Sahd, J. Journal of Clinical Gastroenterology, 20(4):321–324, June, 1995. doi abstract bibtex Primary endocrine neoplasms of intra- and extrahepatic biliary ducts are very rare. We describe the first case of a primary endocrine tumor of the common bile duct producing gastrin. A 53-year-old woman had a 3-year history of recurrent duodenal and gastric ulcers as well as obstructive jaundice. A small neoplasm was found in the lower third of the common bile duct, which showed diffuse gastrin production and focal synthesis of serotonin and pancreatic polypeptide by immunohistochemistry and electron microscopy. Although serum gastrin was within normal levels (90 ng/ml), symptoms of peptic acid disease could have been related to hypergastrinemia, since gastric and duodenal ulcers healed after surgical removal of the tumor. She has remained asymptomatic for 8 months.
@article{mandujano-vera_gastrinoma_1995,
title = {Gastrinoma of the common bile duct: immunohistochemical and ultrastructural study of a case},
volume = {20},
issn = {0192-0790},
shorttitle = {Gastrinoma of the common bile duct},
doi = {10.1097/00004836-199506000-00014},
abstract = {Primary endocrine neoplasms of intra- and extrahepatic biliary ducts are very rare. We describe the first case of a primary endocrine tumor of the common bile duct producing gastrin. A 53-year-old woman had a 3-year history of recurrent duodenal and gastric ulcers as well as obstructive jaundice. A small neoplasm was found in the lower third of the common bile duct, which showed diffuse gastrin production and focal synthesis of serotonin and pancreatic polypeptide by immunohistochemistry and electron microscopy. Although serum gastrin was within normal levels (90 ng/ml), symptoms of peptic acid disease could have been related to hypergastrinemia, since gastric and duodenal ulcers healed after surgical removal of the tumor. She has remained asymptomatic for 8 months.},
language = {eng},
number = {4},
journal = {Journal of Clinical Gastroenterology},
author = {Mandujano-Vera, G. and Angeles-Angeles, A. and de la Cruz-Hernández, J. and Sansores-Pérez, M. and Larriva-Sahd, J.},
month = jun,
year = {1995},
pmid = {7665823},
keywords = {Cholestasis, Common Bile Duct Neoplasms, Duodenal Ulcer, Female, Gastrinoma, Gastrins, Humans, Immunohistochemistry, Middle Aged, Stomach Ulcer},
pages = {321--324},
}
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