Schizophrenic subjects show aberrant fMRI activation of dorsolateral prefrontal cortex and basal ganglia during working memory performance. Manoach, D., Gollub, R., Benson, E., Searl, M., Goff, D., Halpern, E., Saper, C., & Rauch, S. Biol Psychiatry, 48(2):99–109, 2000.
Schizophrenic subjects show aberrant fMRI activation of dorsolateral prefrontal cortex and basal ganglia during working memory performance [link]Paper  doi  abstract   bibtex   
Aberrant WM performance and brain activation in schizophrenia may reflect dysfunction of frontostriatal circuitry that subserves WM. Future studies will elucidate the contribution of the anatomical components of this circuitry to WM deficits.
@article{manoach_schizophrenic_2000,
	title = {Schizophrenic subjects show aberrant {fMRI} activation of dorsolateral prefrontal cortex and basal ganglia during working memory performance},
	volume = {48},
	url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=10903406},
	doi = {10/bw66mp},
	abstract = {Aberrant WM performance and brain activation in schizophrenia may reflect dysfunction of frontostriatal circuitry that subserves WM. Future studies will elucidate the contribution of the anatomical components of this circuitry to WM deficits.},
	number = {2},
	journal = {Biol Psychiatry},
	author = {Manoach, D.S. and Gollub, R.L. and Benson, E.S. and Searl, M.M. and Goff, D.C. and Halpern, E. and Saper, C.B. and Rauch, S.L.},
	year = {2000},
	keywords = {Adult, Basal Ganglia, Brief Psychiatric Rating Scale, Female, Humans, Magnetic Resonance Imaging, Male, Memory Disorders, Prefrontal Cortex, Reaction Time, Schizophrenia, Thalamus},
	pages = {99--109},
}

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