13. Manor, U. Organelle–Organelle Contacts, pages 151-159. John Wiley & Sons, Ltd, 2020. ![Organelle–Organelle Contacts [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Summary This chapter explores the implications of the evolutionary history and provides the mechanisms for organelle-organelle interactions in physiology and pathophysiology. The well-characterized organelle-organelle contact in cell biology is the endoplasmic reticulum (ER)-mitochondria junction. The vast majority of lipid synthesis enzymes are localized to the ER membrane, but several key enzymes reside within the mitochondrial outer membrane. Some phospholipid synthesis requires several key enzymes, some of which are on the ER, and others on mitochondria. Calcium influx from the ER to mitochondria appears to occur in subdomains, highlighting the existence of a highly conserved, highly organized molecular interaction that facilitates the process. Mitochondrial fission is mediated by calcium. VAPs, one of the key protein families mediating ER-autophagosome contacts and autophagosome biogenesis, mediate contacts with multiple other organelles, including the plasma membrane, mitochondria, lysosomes, and Golgi. Lipid droplets (LDs) were thought to be passive lipid-storage facilities until the discovery of multiple proteins and active functions for LDs.
@inbook{doi:https://doi.org/10.1002/9781119436812.ch13,
author = {Manor, Uri},
publisher = {John Wiley & Sons, Ltd},
isbn = {9781119436812},
title = {Organelle–Organelle Contacts},
booktitle = {The Liver},
chapter = {13},
pages = {151-159},
doi = {https://doi.org/10.1002/9781119436812.ch13},
url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/9781119436812.ch13},
eprint = {https://onlinelibrary.wiley.com/doi/pdf/10.1002/9781119436812.ch13},
year = {2020},
keywords = {calcium influx, cell biology, endoplasmic reticulum, ER-autophagosome contact, lipid droplet, lipid synthesis, mitochondrial fission, organelle-organelle contact, phospholipid synthesis},
abstract = {Summary This chapter explores the implications of the evolutionary history and provides the mechanisms for organelle-organelle interactions in physiology and pathophysiology. The well-characterized organelle-organelle contact in cell biology is the endoplasmic reticulum (ER)-mitochondria junction. The vast majority of lipid synthesis enzymes are localized to the ER membrane, but several key enzymes reside within the mitochondrial outer membrane. Some phospholipid synthesis requires several key enzymes, some of which are on the ER, and others on mitochondria. Calcium influx from the ER to mitochondria appears to occur in subdomains, highlighting the existence of a highly conserved, highly organized molecular interaction that facilitates the process. Mitochondrial fission is mediated by calcium. VAPs, one of the key protein families mediating ER-autophagosome contacts and autophagosome biogenesis, mediate contacts with multiple other organelles, including the plasma membrane, mitochondria, lysosomes, and Golgi. Lipid droplets (LDs) were thought to be passive lipid-storage facilities until the discovery of multiple proteins and active functions for LDs.}
}
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