A saltationist theory of cancer evolution

A saltationist theory of cancer evolution. Markowetz, F. Nat. Genet., 48(10):1102--1103, Nature Research, 28~September, 2016.
doi abstract bibtex

A new study based on single-nucleus sequencing reports that triple-negative breast cancers acquire copy number aberrations in short punctuated bursts in the earliest stages of tumor evolution, rather than continuously and gradually, challenging prevailing models of tumor evolution.

@ARTICLE{Markowetz2016-vp,
  title     = "A saltationist theory of cancer evolution",
  author    = "Markowetz, Florian",
  abstract  = "A new study based on single-nucleus sequencing reports that
               triple-negative breast cancers acquire copy number aberrations
               in short punctuated bursts in the earliest stages of tumor
               evolution, rather than continuously and gradually, challenging
               prevailing models of tumor evolution.",
  journal   = "Nat. Genet.",
  publisher = "Nature Research",
  volume    =  48,
  number    =  10,
  pages     = "1102--1103",
  month     =  "28~" # sep,
  year      =  2016,
  keywords  = "chromothripsis;evolution;perspectives;preface;darwinian;brca;pcne;Classics",
  language  = "en",
  issn      = "1061-4036, 1546-1718",
  doi       = "10.1038/ng.3687"
}

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