Localising scalp-invisible interictal epileptic spikes using simultaneous scalp and stereo-EEG. Marquis, R., Spinelli, L., Baud, M., Carboni, M., Mégevand, P., Michel, C., Momjian, S., Schaller, K., Van Mierlo, P., Seeck, M., & Vulliémoz, S. In Schweizerische Gesellschaft für Klinische Neurophysiologie Congress, Aarau, Switzerland, May, 2018. abstract bibtex Background: Cortical generators of interictal epileptic spikes can be accurately localised using high-density scalp electroencephalography (EEG) and electrical source imaging (ESI), as validated by intracranial EEG (icEEG) or epilepsy surgery outcome. The detection of purely medial temporal spikes on scalp EEG remains controversial as well as their localisation using ESI. Methods: We acquired simultaneous icEEG (stereo-EEG) and 256-channels scalp EEG in one patient. We analysed the scalp voltage topography of 97 manually marked icEEG spikes presenting no relevant lateral temporal component and no visible spike on scalp. We selected the 25% scalp segments showing highest correlation between the average and single spike topography (average correlation=0.7±0.1). We applied ESI to these segments with solution points in grey matter (ca. 5 mm spacing). Results: A typical temporal spike was visible on scalp EEG only after averaging. ESI maximum was 15-16 mm from the icEEG contacts with largest responses in the right posterior hippocampus, while contacts closest to ESI maximum (6-7mm) were in the right anterior hippocampus. Discussion: The localization accuracy was comparable to that previously reported in studies in which spikes are visible on the scalp. Future studies, including additional patients, will investigate performance of ESI methods.
@inproceedings{marquis_localising_2018,
address = {Aarau, Switzerland},
title = {Localising scalp-invisible interictal epileptic spikes using simultaneous scalp and stereo-{EEG}},
abstract = {Background: Cortical generators of interictal epileptic spikes can be accurately localised using high-density scalp electroencephalography (EEG) and electrical source imaging (ESI), as validated by intracranial EEG (icEEG) or epilepsy surgery outcome. The detection of purely medial temporal spikes on scalp EEG remains controversial as well as their localisation using ESI. Methods: We acquired simultaneous icEEG (stereo-EEG) and 256-channels scalp EEG in one patient. We analysed the scalp voltage topography of 97 manually marked icEEG spikes presenting no relevant lateral temporal component and no visible spike on scalp. We selected the 25\% scalp segments showing highest correlation between the average and single spike topography (average correlation=0.7±0.1). We applied ESI to these segments with solution points in grey matter (ca. 5 mm spacing). Results: A typical temporal spike was visible on scalp EEG only after averaging. ESI maximum was 15-16 mm from the icEEG contacts with largest responses in the right posterior hippocampus, while contacts closest to ESI maximum (6-7mm) were in the right anterior hippocampus. Discussion: The localization accuracy was comparable to that previously reported in studies in which spikes are visible on the scalp. Future studies, including additional patients, will investigate performance of ESI methods.},
booktitle = {Schweizerische {Gesellschaft} für {Klinische} {Neurophysiologie} {Congress}},
author = {Marquis, Renaud and Spinelli, Laurent and Baud, Maxime and Carboni, Margherita and Mégevand, Pierre and Michel, Christoph and Momjian, Shahan and Schaller, Karl and Van Mierlo, Pieter and Seeck, Margitta and Vulliémoz, Serge},
month = may,
year = {2018}
}
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The detection of purely medial temporal spikes on scalp EEG remains controversial as well as their localisation using ESI. Methods: We acquired simultaneous icEEG (stereo-EEG) and 256-channels scalp EEG in one patient. We analysed the scalp voltage topography of 97 manually marked icEEG spikes presenting no relevant lateral temporal component and no visible spike on scalp. We selected the 25% scalp segments showing highest correlation between the average and single spike topography (average correlation=0.7±0.1). We applied ESI to these segments with solution points in grey matter (ca. 5 mm spacing). Results: A typical temporal spike was visible on scalp EEG only after averaging. ESI maximum was 15-16 mm from the icEEG contacts with largest responses in the right posterior hippocampus, while contacts closest to ESI maximum (6-7mm) were in the right anterior hippocampus. Discussion: The localization accuracy was comparable to that previously reported in studies in which spikes are visible on the scalp. 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The detection of purely medial temporal spikes on scalp EEG remains controversial as well as their localisation using ESI. Methods: We acquired simultaneous icEEG (stereo-EEG) and 256-channels scalp EEG in one patient. We analysed the scalp voltage topography of 97 manually marked icEEG spikes presenting no relevant lateral temporal component and no visible spike on scalp. We selected the 25\\% scalp segments showing highest correlation between the average and single spike topography (average correlation=0.7±0.1). We applied ESI to these segments with solution points in grey matter (ca. 5 mm spacing). Results: A typical temporal spike was visible on scalp EEG only after averaging. ESI maximum was 15-16 mm from the icEEG contacts with largest responses in the right posterior hippocampus, while contacts closest to ESI maximum (6-7mm) were in the right anterior hippocampus. 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