Somatic mutation in cancer and normal cells. Martincorena, I. & Campbell, P. J Science, 349(6255):1483--1489, 25~September, 2015. doi abstract bibtex Spontaneously occurring mutations accumulate in somatic cells throughout a person’s lifetime. The majority of these mutations do not have a noticeable effect, but some can alter key cellular functions. Early somatic mutations can cause developmental disorders, whereas the progressive accumulation of mutations throughout life can lead to cancer and contribute to aging. Genome sequencing has revolutionized our understanding of somatic mutation in cancer, providing a detailed view of the mutational processes and genes that drive cancer. Yet, fundamental gaps remain in our knowledge of how normal cells evolve into cancer cells. We briefly summarize a number of the lessons learned over 5 years of cancer genome sequencing and discuss their implications for our understanding of cancer progression and aging.
@ARTICLE{Martincorena2015-np,
title = "Somatic mutation in cancer and normal cells",
author = "Martincorena, I\~{n}igo and Campbell, Peter J",
abstract = "Spontaneously occurring mutations accumulate in somatic cells
throughout a person’s lifetime. The majority of these mutations
do not have a noticeable effect, but some can alter key cellular
functions. Early somatic mutations can cause developmental
disorders, whereas the progressive accumulation of mutations
throughout life can lead to cancer and contribute to aging.
Genome sequencing has revolutionized our understanding of somatic
mutation in cancer, providing a detailed view of the mutational
processes and genes that drive cancer. Yet, fundamental gaps
remain in our knowledge of how normal cells evolve into cancer
cells. We briefly summarize a number of the lessons learned over
5 years of cancer genome sequencing and discuss their
implications for our understanding of cancer progression and
aging.",
journal = "Science",
volume = 349,
number = 6255,
pages = "1483--1489",
month = "25~" # sep,
year = 2015,
keywords = "evolution;heterogeneity;review;vaf;variant;zotero;Zotero Import
(Aug 30);Zotero Import (Aug 30)/My Library;Zotero Import (Aug
30)/My Library/variants;Classics",
language = "en",
issn = "0036-8075, 1095-9203",
pmid = "26404825",
doi = "10.1126/science.aab4082"
}
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