Somatic mutation in cancer and normal cells. Martincorena, I. and Campbell, P. J Science, 349(6255):1483--1489, 25~September, 2015.
doi  abstract   bibtex   
Spontaneously occurring mutations accumulate in somatic cells throughout a person’s lifetime. The majority of these mutations do not have a noticeable effect, but some can alter key cellular functions. Early somatic mutations can cause developmental disorders, whereas the progressive accumulation of mutations throughout life can lead to cancer and contribute to aging. Genome sequencing has revolutionized our understanding of somatic mutation in cancer, providing a detailed view of the mutational processes and genes that drive cancer. Yet, fundamental gaps remain in our knowledge of how normal cells evolve into cancer cells. We briefly summarize a number of the lessons learned over 5 years of cancer genome sequencing and discuss their implications for our understanding of cancer progression and aging.
@ARTICLE{Martincorena2015-np,
  title    = "Somatic mutation in cancer and normal cells",
  author   = "Martincorena, I\~{n}igo and Campbell, Peter J",
  abstract = "Spontaneously occurring mutations accumulate in somatic cells
              throughout a person’s lifetime. The majority of these mutations
              do not have a noticeable effect, but some can alter key cellular
              functions. Early somatic mutations can cause developmental
              disorders, whereas the progressive accumulation of mutations
              throughout life can lead to cancer and contribute to aging.
              Genome sequencing has revolutionized our understanding of somatic
              mutation in cancer, providing a detailed view of the mutational
              processes and genes that drive cancer. Yet, fundamental gaps
              remain in our knowledge of how normal cells evolve into cancer
              cells. We briefly summarize a number of the lessons learned over
              5 years of cancer genome sequencing and discuss their
              implications for our understanding of cancer progression and
              aging.",
  journal  = "Science",
  volume   =  349,
  number   =  6255,
  pages    = "1483--1489",
  month    =  "25~" # sep,
  year     =  2015,
  keywords = "evolution;heterogeneity;review;vaf;variant;zotero;Zotero Import
              (Aug 30);Zotero Import (Aug 30)/My Library;Zotero Import (Aug
              30)/My Library/variants;Classics",
  language = "en",
  issn     = "0036-8075, 1095-9203",
  pmid     = "26404825",
  doi      = "10.1126/science.aab4082"
}
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