@ARTICLE{Martinez-Cerdeno2010-xt,
  title    = "Embryonic {MGE} precursor cells grafted into adult rat striatum
              integrate and ameliorate motor symptoms in {6-OHDA-lesioned} rats",
  author   = "Mart{\'\i}nez-Cerde{\~n}o, Ver{\'o}nica and Noctor, Stephen C and
              Espinosa, Ana and Ariza, Jeanelle and Parker, Philip and Orasji,
              Samantha and Daadi, Marcel M and Bankiewicz, Krystof and
              Alvarez-Buylla, Arturo and Kriegstein, Arnold R",
  abstract = "We investigated a strategy to ameliorate the motor symptoms of
              rats that received 6-hydroxydopamine (6-OHDA) lesions, a rodent
              model of Parkinson's disease, through transplantation of
              embryonic medial ganglionic eminence (MGE) cells into the
              striatum. During brain development, embryonic MGE cells migrate
              into the striatum and neocortex where they mature into GABAergic
              interneurons and play a key role in establishing the balance
              between excitation and inhibition. Unlike most other embryonic
              neurons, MGE cells retain the capacity for migration and
              integration when transplanted into the postnatal and adult brain.
              We performed MGE cell transplantation into the basal ganglia of
              control and 6-OHDA-lesioned rats. Transplanted MGE cells
              survived, differentiated into GABA(+) neurons, integrated into
              host circuitry, and modified motor behavior in both lesioned and
              control rats. Our data suggest that MGE cell transplantation into
              the striatum is a promising approach to investigate the potential
              benefits of remodeling basal ganglia circuitry in
              neurodegenerative diseases.",
  journal  = "Cell Stem Cell",
  volume   =  6,
  number   =  3,
  pages    = "238--250",
  month    =  mar,
  year     =  2010,
  language = "en"
}

{"_id":"WC6XitmAxxgmLSf3c","bibbaseid":"martnezcerdeo-noctor-espinosa-ariza-parker-orasji-daadi-bankiewicz-etal-embryonicmgeprecursorcellsgraftedintoadultratstriatumintegrateandamelioratemotorsymptomsin6ohdalesionedrats-2010","author_short":["Martı́nez-Cerdeño, Verónica","Noctor, S. C","Espinosa, A.","Ariza, J.","Parker, P.","Orasji, S.","Daadi, M. M","Bankiewicz, K.","Alvarez-Buylla, A.","Kriegstein, A. R"],"bibdata":{"bibtype":"article","type":"article","title":"Embryonic MGE precursor cells grafted into adult rat striatum integrate and ameliorate motor symptoms in 6-OHDA-lesioned rats","author":[{"firstnames":[],"propositions":[],"lastnames":["Martı́nez-Cerdeño, Verónica"],"suffixes":[]},{"propositions":[],"lastnames":["Noctor"],"firstnames":["Stephen","C"],"suffixes":[]},{"propositions":[],"lastnames":["Espinosa"],"firstnames":["Ana"],"suffixes":[]},{"propositions":[],"lastnames":["Ariza"],"firstnames":["Jeanelle"],"suffixes":[]},{"propositions":[],"lastnames":["Parker"],"firstnames":["Philip"],"suffixes":[]},{"propositions":[],"lastnames":["Orasji"],"firstnames":["Samantha"],"suffixes":[]},{"propositions":[],"lastnames":["Daadi"],"firstnames":["Marcel","M"],"suffixes":[]},{"propositions":[],"lastnames":["Bankiewicz"],"firstnames":["Krystof"],"suffixes":[]},{"propositions":[],"lastnames":["Alvarez-Buylla"],"firstnames":["Arturo"],"suffixes":[]},{"propositions":[],"lastnames":["Kriegstein"],"firstnames":["Arnold","R"],"suffixes":[]}],"abstract":"We investigated a strategy to ameliorate the motor symptoms of rats that received 6-hydroxydopamine (6-OHDA) lesions, a rodent model of Parkinson's disease, through transplantation of embryonic medial ganglionic eminence (MGE) cells into the striatum. During brain development, embryonic MGE cells migrate into the striatum and neocortex where they mature into GABAergic interneurons and play a key role in establishing the balance between excitation and inhibition. Unlike most other embryonic neurons, MGE cells retain the capacity for migration and integration when transplanted into the postnatal and adult brain. We performed MGE cell transplantation into the basal ganglia of control and 6-OHDA-lesioned rats. Transplanted MGE cells survived, differentiated into GABA(+) neurons, integrated into host circuitry, and modified motor behavior in both lesioned and control rats. Our data suggest that MGE cell transplantation into the striatum is a promising approach to investigate the potential benefits of remodeling basal ganglia circuitry in neurodegenerative diseases.","journal":"Cell Stem Cell","volume":"6","number":"3","pages":"238–250","month":"March","year":"2010","language":"en","bibtex":"@ARTICLE{Martinez-Cerdeno2010-xt,\n title = \"Embryonic {MGE} precursor cells grafted into adult rat striatum\n integrate and ameliorate motor symptoms in {6-OHDA-lesioned} rats\",\n author = \"Mart{\\'\\i}nez-Cerde{\\~n}o, Ver{\\'o}nica and Noctor, Stephen C and\n Espinosa, Ana and Ariza, Jeanelle and Parker, Philip and Orasji,\n Samantha and Daadi, Marcel M and Bankiewicz, Krystof and\n Alvarez-Buylla, Arturo and Kriegstein, Arnold R\",\n abstract = \"We investigated a strategy to ameliorate the motor symptoms of\n rats that received 6-hydroxydopamine (6-OHDA) lesions, a rodent\n model of Parkinson's disease, through transplantation of\n embryonic medial ganglionic eminence (MGE) cells into the\n striatum. During brain development, embryonic MGE cells migrate\n into the striatum and neocortex where they mature into GABAergic\n interneurons and play a key role in establishing the balance\n between excitation and inhibition. Unlike most other embryonic\n neurons, MGE cells retain the capacity for migration and\n integration when transplanted into the postnatal and adult brain.\n We performed MGE cell transplantation into the basal ganglia of\n control and 6-OHDA-lesioned rats. Transplanted MGE cells\n survived, differentiated into GABA(+) neurons, integrated into\n host circuitry, and modified motor behavior in both lesioned and\n control rats. Our data suggest that MGE cell transplantation into\n the striatum is a promising approach to investigate the potential\n benefits of remodeling basal ganglia circuitry in\n neurodegenerative diseases.\",\n journal = \"Cell Stem Cell\",\n volume = 6,\n number = 3,\n pages = \"238--250\",\n month = mar,\n year = 2010,\n language = \"en\"\n}\n\n","author_short":["Martı́nez-Cerdeño, Verónica","Noctor, S. C","Espinosa, A.","Ariza, J.","Parker, P.","Orasji, S.","Daadi, M. M","Bankiewicz, K.","Alvarez-Buylla, A.","Kriegstein, A. R"],"key":"Martinez-Cerdeno2010-xt","id":"Martinez-Cerdeno2010-xt","bibbaseid":"martnezcerdeo-noctor-espinosa-ariza-parker-orasji-daadi-bankiewicz-etal-embryonicmgeprecursorcellsgraftedintoadultratstriatumintegrateandamelioratemotorsymptomsin6ohdalesionedrats-2010","role":"author","urls":{},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/f/EJMp3HRuxirjxpcXh/references.bib","dataSources":["sAFYeB74DpbdXM9NN","4zx9n2tbeLTix3Wxr","k3cdWrThyTh5o59Rm","hq9pebjzmsTuyxGGx","h8Atv2SAy4PmShg5j"],"keywords":[],"search_terms":["embryonic","mge","precursor","cells","grafted","adult","rat","striatum","integrate","ameliorate","motor","symptoms","ohda","lesioned","rats","martı́nez-cerdeño","noctor","espinosa","ariza","parker","orasji","daadi","bankiewicz","alvarez-buylla","kriegstein"],"title":"Embryonic MGE precursor cells grafted into adult rat striatum integrate and ameliorate motor symptoms in 6-OHDA-lesioned rats","year":2010}