@ARTICLE{Martinez-Cerdeno2006-md,
  title    = "Estradiol stimulates progenitor cell division in the ventricular
              and subventricular zones of the embryonic neocortex",
  author   = "Mart{\'\i}nez-Cerde{\~n}o, Ver{\'o}nica and Noctor, Stephen C and
              Kriegstein, Arnold R",
  abstract = "Two distinct populations of cerebral cortical progenitor cells
              that generate neurons during embryogenesis have been identified:
              radial glial cells and intermediate progenitor cells. Despite
              advances in our understanding of progenitor cell populations, we
              know relatively little about factors that regulate their
              proliferative behaviour. 17-beta-Estradiol (E2) is present in the
              adult and developing mammalian brain, and plays an important role
              in central nervous system processes such as neuronal
              differentiation, survival and plasticity. E2 also stimulates
              neurogenesis in the adult dentate gyrus. We examined the role of
              E2 during embryonic cortical neurogenesis through
              immunohistochemistry, in situ hybridization, functional enzyme
              assay, organotypic culture and in utero administration of
              estradiol-blocking agents in mice. We show that aromatase, the E2
              synthesizing enzyme, is present in the embryonic neocortex, that
              estrogen receptor-alpha is present in progenitor cells during
              cortical neurogenesis, that in vitro E2 administration rapidly
              promotes proliferation, and that in utero blockade of estrogen
              receptors decreases proliferation of embryonic cortical
              progenitor cells. Furthermore, the E2 inhibitor alpha-fetoprotein
              is expressed at high levels by radial glial cells but at lower
              levels by intermediate progenitor cells, suggesting that E2
              differentially influences the proliferation of these cortical
              progenitor cell types. These findings demonstrate a new
              functional role for E2 as a proliferative agent during critical
              stages of cerebral cortex development.",
  journal  = "Eur J Neurosci",
  volume   =  24,
  number   =  12,
  pages    = "3475--3488",
  month    =  dec,
  year     =  2006,
  address  = "France",
  language = "en"
}

{"_id":"52nQrSEzpu5akNWwj","bibbaseid":"martnezcerdeo-noctor-kriegstein-estradiolstimulatesprogenitorcelldivisionintheventricularandsubventricularzonesoftheembryonicneocortex-2006","author_short":["Martı́nez-Cerdeño, Verónica","Noctor, S. C","Kriegstein, A. R"],"bibdata":{"bibtype":"article","type":"article","title":"Estradiol stimulates progenitor cell division in the ventricular and subventricular zones of the embryonic neocortex","author":[{"firstnames":[],"propositions":[],"lastnames":["Martı́nez-Cerdeño, Verónica"],"suffixes":[]},{"propositions":[],"lastnames":["Noctor"],"firstnames":["Stephen","C"],"suffixes":[]},{"propositions":[],"lastnames":["Kriegstein"],"firstnames":["Arnold","R"],"suffixes":[]}],"abstract":"Two distinct populations of cerebral cortical progenitor cells that generate neurons during embryogenesis have been identified: radial glial cells and intermediate progenitor cells. Despite advances in our understanding of progenitor cell populations, we know relatively little about factors that regulate their proliferative behaviour. 17-beta-Estradiol (E2) is present in the adult and developing mammalian brain, and plays an important role in central nervous system processes such as neuronal differentiation, survival and plasticity. E2 also stimulates neurogenesis in the adult dentate gyrus. We examined the role of E2 during embryonic cortical neurogenesis through immunohistochemistry, in situ hybridization, functional enzyme assay, organotypic culture and in utero administration of estradiol-blocking agents in mice. We show that aromatase, the E2 synthesizing enzyme, is present in the embryonic neocortex, that estrogen receptor-alpha is present in progenitor cells during cortical neurogenesis, that in vitro E2 administration rapidly promotes proliferation, and that in utero blockade of estrogen receptors decreases proliferation of embryonic cortical progenitor cells. Furthermore, the E2 inhibitor alpha-fetoprotein is expressed at high levels by radial glial cells but at lower levels by intermediate progenitor cells, suggesting that E2 differentially influences the proliferation of these cortical progenitor cell types. These findings demonstrate a new functional role for E2 as a proliferative agent during critical stages of cerebral cortex development.","journal":"Eur J Neurosci","volume":"24","number":"12","pages":"3475–3488","month":"December","year":"2006","address":"France","language":"en","bibtex":"@ARTICLE{Martinez-Cerdeno2006-md,\n title = \"Estradiol stimulates progenitor cell division in the ventricular\n and subventricular zones of the embryonic neocortex\",\n author = \"Mart{\\'\\i}nez-Cerde{\\~n}o, Ver{\\'o}nica and Noctor, Stephen C and\n Kriegstein, Arnold R\",\n abstract = \"Two distinct populations of cerebral cortical progenitor cells\n that generate neurons during embryogenesis have been identified:\n radial glial cells and intermediate progenitor cells. Despite\n advances in our understanding of progenitor cell populations, we\n know relatively little about factors that regulate their\n proliferative behaviour. 17-beta-Estradiol (E2) is present in the\n adult and developing mammalian brain, and plays an important role\n in central nervous system processes such as neuronal\n differentiation, survival and plasticity. E2 also stimulates\n neurogenesis in the adult dentate gyrus. We examined the role of\n E2 during embryonic cortical neurogenesis through\n immunohistochemistry, in situ hybridization, functional enzyme\n assay, organotypic culture and in utero administration of\n estradiol-blocking agents in mice. We show that aromatase, the E2\n synthesizing enzyme, is present in the embryonic neocortex, that\n estrogen receptor-alpha is present in progenitor cells during\n cortical neurogenesis, that in vitro E2 administration rapidly\n promotes proliferation, and that in utero blockade of estrogen\n receptors decreases proliferation of embryonic cortical\n progenitor cells. Furthermore, the E2 inhibitor alpha-fetoprotein\n is expressed at high levels by radial glial cells but at lower\n levels by intermediate progenitor cells, suggesting that E2\n differentially influences the proliferation of these cortical\n progenitor cell types. These findings demonstrate a new\n functional role for E2 as a proliferative agent during critical\n stages of cerebral cortex development.\",\n journal = \"Eur J Neurosci\",\n volume = 24,\n number = 12,\n pages = \"3475--3488\",\n month = dec,\n year = 2006,\n address = \"France\",\n language = \"en\"\n}\n\n","author_short":["Martı́nez-Cerdeño, Verónica","Noctor, S. C","Kriegstein, A. R"],"key":"Martinez-Cerdeno2006-md","id":"Martinez-Cerdeno2006-md","bibbaseid":"martnezcerdeo-noctor-kriegstein-estradiolstimulatesprogenitorcelldivisionintheventricularandsubventricularzonesoftheembryonicneocortex-2006","role":"author","urls":{},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/f/EJMp3HRuxirjxpcXh/references.bib","dataSources":["sAFYeB74DpbdXM9NN","4zx9n2tbeLTix3Wxr","k3cdWrThyTh5o59Rm","hq9pebjzmsTuyxGGx","h8Atv2SAy4PmShg5j"],"keywords":[],"search_terms":["estradiol","stimulates","progenitor","cell","division","ventricular","subventricular","zones","embryonic","neocortex","martı́nez-cerdeño","noctor","kriegstein"],"title":"Estradiol stimulates progenitor cell division in the ventricular and subventricular zones of the embryonic neocortex","year":2006}