The role of intermediate progenitor cells in the evolutionary expansion of the cerebral cortex. Martı́nez-Cerdeño, Verónica, Noctor, S. C, & Kriegstein, A. R Cereb Cortex, 16 Suppl 1:i152–61, United States, July, 2006.
abstract   bibtex   
The vertebrate cerebral cortex varies from the 3-layered dorsal cortex of reptiles to the 6-layered lissencephalic cortex characteristic of rodents and to the 6-layered gyrencephalic cortex typical of carnivores and primates. Distinct developmental mechanisms may have evolved independently to account for the radial expansion that produced the multilayered cortex of mammals and for the tangential expansion of cortical surface area that resulted in gyrencephalic cortex. Recent evidence shows that during the late stages of cortical development, radial glial cells divide asymmetrically in the ventricular zone to generate radial glial cells and intermediate progenitor (IP) cells and that IP cells subsequently divide symmetrically in the subventricular zone to produce multiple neurons. We propose that the evolution of this two-step pattern of neurogenesis played an important role in the amplification of cell numbers underlying the radial and tangential expansion of the cerebral cortex.
@ARTICLE{Martinez-Cerdeno2006-ul,
  title    = "The role of intermediate progenitor cells in the evolutionary
              expansion of the cerebral cortex",
  author   = "Mart{\'\i}nez-Cerde{\~n}o, Ver{\'o}nica and Noctor, Stephen C and
              Kriegstein, Arnold R",
  abstract = "The vertebrate cerebral cortex varies from the 3-layered dorsal
              cortex of reptiles to the 6-layered lissencephalic cortex
              characteristic of rodents and to the 6-layered gyrencephalic
              cortex typical of carnivores and primates. Distinct developmental
              mechanisms may have evolved independently to account for the
              radial expansion that produced the multilayered cortex of mammals
              and for the tangential expansion of cortical surface area that
              resulted in gyrencephalic cortex. Recent evidence shows that
              during the late stages of cortical development, radial glial
              cells divide asymmetrically in the ventricular zone to generate
              radial glial cells and intermediate progenitor (IP) cells and
              that IP cells subsequently divide symmetrically in the
              subventricular zone to produce multiple neurons. We propose that
              the evolution of this two-step pattern of neurogenesis played an
              important role in the amplification of cell numbers underlying
              the radial and tangential expansion of the cerebral cortex.",
  journal  = "Cereb Cortex",
  volume   = "16 Suppl 1",
  pages    = "i152--61",
  month    =  jul,
  year     =  2006,
  address  = "United States",
  language = "en"
}

Downloads: 0